A5061435918- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Pregnancy and preeclampsia studies
- Colorectal and Anal Carcinomas
- Ectopic Pregnancy Diagnosis and Management
- Genital Health and Disease
- RNA modifications and cancer
- Maternal and fetal healthcare
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- MicroRNA in disease regulation
- Reproductive tract infections research
- AI in cancer detection
- Gestational Trophoblastic Disease Studies
- Birth, Development, and Health
- Uterine Myomas and Treatments
- Advanced Algorithms and Applications
Qilu Hospital of Shandong University
2016-2025
Chinese PLA General Hospital
2025
Harbin Medical University
2025
Third Affiliated Hospital of Harbin Medical University
2025
Shandong University
2005-2024
Guangzhou University
2024
Gannan Medical University
2024
Barro Colorado Island
2024
Community Link
2023
Peking Union Medical College Hospital
2020
OBJECTIVE: To establish a new cesarean scar ectopic pregnancy clinical classification system with recommended individual surgical strategy and to evaluate its efficacy in treatment of pregnancy. METHODS: This retrospective cohort study included patients Qilu Hospital Shandong, China. From 2008 2015, were determine risk factors for intraoperative hemorrhage during treatment. Univariable analysis multivariable logistic regression analyses used explore the independent (300 mL or greater)...
Circular RNAs (circRNAs) represent a widespread class of non-coding RNAs, which drew little attention in the past. Recently, limited data showed their promising future to act as biomarkers human cancer, but characteristics and functions remain largely unknown hematopoietic malignancies, especially leukemia. In this study, with help circRNA microarray, we demonstrated expression profile circRNAs acute myeloid leukemia (AML) patients, identified large number possibly expressed specific manner....
Cervical cancer screening by combined cytology and HPV test has reduced the incidence of cervical cancer, but cytological lacks a higher sensitivity while testing possesses lower specificity. Most patients with invasive are treated radiotherapy. However, insensitivity to radiotherapy leads poor efficacy. Illumina Methylation EPIC 850k Beadchip was used for genomic screening. We detected methylation SEPT9 mRNA expression in different tissues using methylation-specific PCR qRT-PCR. Then CCK8,...
Abstract Circular RNAs (circRNAs) participate in gene regulation and malignant tumor progression, including uterine cervical cancer (CC). In this study, the expression profile of circRNAs CC was detected using circRNA microarrays. Then, we selected hsa_circ_0000745 for further examination from significantly dysregulated circRNAs. Proliferation assays, Transwell quantitative reverse transcription polymerase chain reaction, western blot analysis tumorigenesis tests vivo were used to validate...
Abstract N 6-methyladenosine (m6A) is the most abundant mRNA modification in mammals and it plays a vital role various biological processes. However, roles of m6A on cervical cancer tumorigenesis, especially macrophages infiltrated tumor microenvironment cancer, are still unclear. We analyzed abnormal methylation using CaSki THP-1 cell lines, that might influence macrophage polarization and/or function microenvironment. In addition, C57BL/6J BALB/c nude mice were used for validation vivo....
Preeclampsia (PE) is a severe pregnancy complication characterized by hypertension and proteinuria. PE poses substantial threat to the health of both mothers fetuses, currently, there no definitive treatment available. Recent studies have indicated that transcription factor GATA1 may be implicated in pathological processes PE, but underlying mechanism remains elusive. NTRK2/cGMP–PKG signaling pathway plays crucial role regulating function polarization macrophages, which are key immune cells...
Background: This study investigates the role and efficacy of acupuncture combined with rehabilitation therapy during recovery phase patients traumatic spinal cord injury. Patients hospitalized in department our center between December 1, 2019, 2021, were enrolled. Methods: Participants divided into an observation group (acupuncture therapy) a control (rehabilitation alone) based on their treatment sequence. Initially, 15 allocated to each group; however, 3 4 withdrew, leaving 11 12...
SLC7A11 is importantly in both ferroptosis and disulfidptosis which participated human development homeostasis. By utilizing bioinformatics vitro validation, we explored SLC7A11's role cervical cancer. From the TCGA database, analyzed expression profiles validated its promoting cancer by vitro. Patients were divided into two subgroups according to levels, differentially expressed genes (DEGs) identified between these groups. Then mechanism was then clarified function enrichment analysis. The...
Integrated energy systems (IESs) can realize the conversion and complementarity of various sources, which provides opportunities challenges for market. Considering that user’s consumption is affected by price difference, there a problem new output in comprehensive system does not fully match demand period. In order to solve above problems, this paper proposes two‐stage optimization model “open source reducing expenditure” give full play potential multiple sources on load side participate...
ABSTRACT Cancer is one of the leading causes cancer‐related deaths worldwide and also among most common malignant tumors digestive system. With decreasing age onset, there an urgent need to develop effective therapeutic strategies improve patient survival. RAN‐binding protein 9 (RANBP9) has been identified as oncogene involved in several cancers, including colon cancer, gastric lung cancer. It plays a crucial role inhibiting tumor metastasis enhancing chemotherapy sensitivity. In this study,...
Aim: To develop and validate a deep learning radiomics model, which could predict the lymph node metastases preoperatively in cervical cancer patients. Patients methods: We included cohort of 226 pathological proven operable patients two academic medical institutions from December 2014 to November 2017. Then this dataset was split into training set (n = 176) independent testing 50) randomly. Five radiomic features were selected signature established. then combined these five with...
This study was designed to investigate whether there is a correlation between the down-regulation of microRNA-218 (miR-218) and presence human papillomavirus (HPV) infection in pathogenesis cervical cancer. The participants comprised 78 women with intraepithelial neoplasia (CIN); 22 (28.2%) had CIN 1, 27 (34.6%) 2 29 (37.2%) 3. MiR-218 expression determined by reverse transcriptase polymerase chain reaction HPV genotypes tissue specimens were identified microarray test kit. findings showed...
Abstract Background To investigate distributions of cervical lesions and factors associated with the severity in high-risk HPV (hr-HPV) positive women atypical squamous cells undetermined significance (ASC-US) cytology. Methods Clinical information 250,000 who underwent cytological test was collected from January 2012 to 2019. The association between hr-HPV genotypes, viral load, ages, were analyzed hr-HPV-positive/ASC-US women. Results 3459 enrolled this study. Overall, 43.51% ASC-US had...
Peripheral systemic inflammatory, nutritional, and coagulation biomarkers have prognostic predictive value in various malignancies. We evaluated the roles of circulating blood patients with advanced cervical cancer.A retrospective study 795 cancer who received concurrent chemoradiation therapy was performed. Overall survival by Kaplan-Meier estimator. Univariate multivariate Cox regression models were used to determine factors associated overall survival.The median follow-up time 76 months....
Background Cervical cancer has the second-highest mortality rate among malignant tumors of female reproductive system. Immune checkpoint inhibitors such as programmed cell death protein 1 (PD-1) blockade are promising therapeutic agents, but their efficacy when combined with neoadjuvant chemotherapy (NACT) not been fully tested, and how they alter tumor microenvironment comprehensively elucidated. Methods In this study, we conducted single-cell RNA sequencing using 46,950 cells from nine...