A5101709236- DNA Repair Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Liver Diseases and Immunity
- Fibroblast Growth Factor Research
- Adipose Tissue and Metabolism
- PARP inhibition in cancer therapy
- Genomics and Chromatin Dynamics
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- Multiple and Secondary Primary Cancers
- Bacteriophages and microbial interactions
- Vitamin K Research Studies
- Immune Cell Function and Interaction
- Glutathione Transferases and Polymorphisms
- Natural product bioactivities and synthesis
- Kruppel-like factors research
- Fungal and yeast genetics research
People's Liberation Army No. 150 Hospital
2025
Harbin Medical University
2015-2024
Second Affiliated Hospital of Harbin Medical University
2015-2024
Chinese PLA General Hospital
2024
Jiangsu University
2019-2023
Affiliated Hospital of Jiangsu University
2019-2023
Sichuan University
2014-2023
U-M Rogel Cancer Center
2007
University of Cambridge
2007
University of Maryland, Baltimore
2007
The cytolytic ionotropic ATP receptor P2X<sub>7</sub> has several important roles in immune cell regulation, such as cytokine release, apoptosis, and microbial killing. Although receptors are frequently coexpressed with another subtype of P2X receptor, P2X<sub>4</sub>, they believed not to form heteromeric assemblies but function only homomers. Both play a role neuropathic pain; therefore, understanding how coordinate the cellular response is for development effective pain therapies. Here,...
Background/aim: Previous studies have suggested that the hepatic steatosis index (HSI) and fatty liver (FLI) can be used as a predictor of non-alcoholic disease (NAFLD).The aim our study was to determine whether non-invasive indices (HSI FLI) are associated with carotid atherosclerosis in type 2 diabetes mellitus (T2DM).Methods: This cross-sectional conducted T2DM patients (n=768).Carotid intima-media thickness (CIMT) measured by Color Doppler ultrasound.The HSI calculated based on gender,...
BACKGROUND: Thrombocytopenia and leukopenia are common complications of alcoholic liver cirrhosis (ALC) associated with an increased risk bleeding, infection mortality. OBJECTIVES: Evaluate the effectiveness safety leucogen, a cysteine derivative that increases platelet (PLT) white blood cell (WBC) counts in ALC patients. DESIGN: Retrospective SETTING: Department hepatology, general hospital PATIENTS AND METHODS: Patients who had thrombocytopenia and/or were enrolled between 2022 2023...
Currently, research on biopsy-proven acute drug-induced liver injury (DILI) remains limited. This study aimed to identify clinical characteristics and risk factors for significant hepatic inflammation in patients with DILI. An ambispective cohort was conducted DILI admitted our hospital from 2012 2018. Using the Scheuer scoring system, were categorized into G0-2 or G3-4 groups followed up 12 months after first admission. Clinical outcomes retrieved medical records. The median age of 157...
Abstract Recent studies indicate that secondary bile acids promote colon cancer cell proliferation but their role in maintaining survival has not been explored. We found deoxycholyltaurine (DCT) markedly attenuated both unstimulated and TNF‐α‐stimulated programmed death cells by a phosphatidylinositol 3‐kinase (PI3K)‐dependent mechanism. To examine the of PI3K signaling survival, we explored downstream acid‐induced activation epidermal growth factor receptor (EGFR) regulating apoptosis HT‐29...
Ionizing radiation (IR) is known to activate multiple signaling pathways, resulting in diverse stress responses including apoptosis, cell cycle arrest, and gene induction. IR-activated checkpoints are regulated by Ser/Thr phosphorylation, so we tested see if protein phosphatases were targets of an damage-sensing pathway. Jurkat cells subjected IR or sham followed brief (32)P metabolic labeling. Nuclear extracts microcystin affinity chromatography recover phosphatases, the proteins analyzed...
We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Based on urinary albumin/creatinine ratio (UACR), 207 T2DM were divided into normoalbuminuria (UACR<30 mg/g), microalbuminuria (30≤UACR<300 macroalbuminuria (UACR≥300 mg/g). Serum determined by enzyme-linked immunosorbent assay.Comparatively, patient groups [2.37 (1.63-3.57)] [2.10 (1.60-2.90)]...
Ionizing radiation is known to activate multiple signal transduction pathways, but the targets of these pathways are poorly understood. Phosphorylation histone H1 thought have a role in chromatin condensation/decondensation, and we asked whether ionizing (IR) would alter phosphorylation. Our data demonstrate that low doses IR result dramatic, transient, dephosphorylation isoforms. The vivo IR-induced completely blocked by wortmannin abrogated ataxia telangiectasia cells. Furthermore,...
Purpose Triglyceride-glucose (TyG) index is a reliable and inexpensive alternative indicator of insulin resistance. Previous studies have shown that elevated TyG increases the risk diabetes, coronary heart disease, other diseases, but relationship between cardiac hemodynamics in patients with type 2 diabetes mellitus (T2DM) not clear. This study was conducted T2DM to assess its predictive ability for T2DM. Methods A total 647 individuals (348 males 299 females) were enrolled this study,...
Purpose: The purpose of this study was to test whether glucagon-like peptide-1 (GLP-1) receptor activation preserved pancreatic β-cells via the regulation microRNAs and target genes in high-fat-diet-fed mice. Methods: C57BL/6 male mice were simultaneously treated with high-fat-diet (HFD) GLP-1 analogue, Exendin-4 (Ex-4) (3 μg/kg/day or 30 μg/kg/day), i.p. vehicle, for consecutive 13 weeks. Fasting blood glucose, postprandial ΔI30/ΔG30, HOMA-IR HOMA-% β measured each group. Pancreatic β-cell...
Diabetic nephropathy (DN) is a common complication of diabetes, and it also the main cause chronic renal failure. Physiological/pathological changes mediated by high glucose are factors causing injury DN, including enhancement polyol pathway, accumulation advanced glycation products (AGEs), activation protein kinase C (PKC) transforming growth factor-β (TGF-β) signals. In addition, abnormal renin-angiotensin system (RAS) oxidative stress involved. Melatonin physiological hormone mainly...
Angiopoietin-like protein 8 (ANGPTL8), a newly identified hormone, has been recently characterized as metabolic regulator which can affect energy homeostasis and interesting potentials disease therapy. However, little is yet known to whether circulating ANGPTL8 levels are altered in thyroid dysfunction. This study measured serum patients with Graves' explored the correlations between its index disease. The concentration of was analyzed blood samples 128 well-characterized individuals whose...
ANGPTL8 is a cytokine expressed and secreted by liver adipose tissue, involved in glucose, lipid, energy metabolism. Although studies have shown that elevated type 2 diabetes mellitus (T2DM) cardiovascular disease, few examined the association between single-nucleotide polymorphisms risk of macrovascular complications T2DM patients. This study aimed to explore relationship rs2278426 carotid intima-media thickening (cIMT) T2DM.A total 217 patients 201 healthy control subjects with normal...