A5040228995- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Viral Infectious Diseases and Gene Expression in Insects
- MicroRNA in disease regulation
- Insect Resistance and Genetics
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- RNA modifications and cancer
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Fluoride Effects and Removal
- PARP inhibition in cancer therapy
- interferon and immune responses
- Heat shock proteins research
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Insects and Parasite Interactions
- Mercury impact and mitigation studies
- Phytochemicals and Antioxidant Activities
- Entomopathogenic Microorganisms in Pest Control
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
Jiangsu University
2012-2024
Johns Hopkins Medicine
2015-2018
Johns Hopkins University
2015-2018
Chinese Academy of Sciences
2009-2013
Institute of Microbiology
2009-2013
Hepatitis B virus (HBV) causes chronic infection in about 350 million people worldwide. Given the important role of most abundant liver-specific microRNA, miR-122, hepatic function and liver pathology, here we investigated potential mechanism miR-122 regulating HBV replication. We found that expression was significantly down-regulated patients with compared healthy controls, levels were negatively correlated intrahepatic viral load necroinflammation. The depletion endogenous by its antisense...
Hepatocellular carcinoma (HCC) is one of the most common cancers in world. Circular RNAs (circRNAs) are a new class endogenous functional non-coding (ncRNAs), and have been demonstrated to play important roles development HCC. This study aimed explore significance circRNAs HCC progression. HCC-associated circRNA expression profiles GSE94508 GSE97332 were downloaded from Gene Expression Omnibus database (GEO), 87 differentially expressed (DECs) between tissues paired non-cancer identified,...
Abstract Exposure to cockroach allergen is a strong risk factor for developing asthma. Asthma has been associated with allergen-induced airway epithelial damage and heightened oxidant stress. In this study, we investigated allergen–induced oxidative stress in epithelium its underlying mechanisms. We found that extract (CRE) could induce reactive oxygen species (ROS) production, particularly mitochondrial-derived ROS, human bronchial cells. then used the RT2 Profiler PCR array identified...
Exposure to cockroach allergen leads allergic sensitization and increased risk of developing asthma. Aryl hydrocarbon receptor (AhR), a for many common environmental contaminants, can sense not only pollutants but also microbial insults. Mesenchymal stem cells (MSCs) are multipotent progenitor with the capacity modulate immune responses. In this study, we investigated whether AhR allergens allergen-induced lung inflammation through MSCs. We found that allergen-treated AhR-deficient...
Stems are the important residues of Trapa quadrispinosa Roxb., which abundant in phenolic compounds. Ultrasonic-assisted enzymatic extraction (UAEE) is confirmed as a novel technology with main advantages enhancing yield and physiological activities extracts from various plants. In this study, UAEE was applied to obtain highest content, strongest antioxidant, antitumor optimize conditions using response surface methodology (RSM). The stems T. were characterized by determination their...
Abstract HSP gp96‐based vaccines have been trialled in rodent models and, more recently, humans. Better understanding of gp96's immunomodulatory role will help with the design effective strategies for treatment cancer and infectious diseases. In this study, we monitored activities T cells activation Treg BABL/c mice after immunization using different doses gp96 as adjuvant. We found that co‐injection simultaneously stimulated both CTL activity. Activation at low dose was far pronounced than...
Non-small cell lung cancer (NSCLC) is one of the leading causes death in world, and has a relatively low survival rate. Long non-coding RNAs (lncRNAs) have been demonstrated to modulate progression through variety molecular mechanisms. We sought investigate role potential mechanism MYC-induced long RNA (MINCR) NSCLC. Expression levels MINCR was first identified using The Cancer Genome Atlas (TCGA), further confirmed with specimens from 29 NSCLC patients three lines qRT-PCR. Overexpression...
The heat shock protein gp96 elicits specific T cell responses to its chaperoned peptides against cancer and infectious diseases in both rodent models clinical trials. Although gp96-induced innate immunity, via a subset of Toll like receptors (TLRs), adaptive through antigen presentation, are believed be important for priming potent responses, direct evidence the role gp96-mediated TLR activation related functional is lacking. Here, we report that containing mutations TLR-binding domain...
Bm-SP142 is a 35 kDa protease in the silkworm, but its exact functions remain unknown. In this study, sequence alignment revealed that His-Asp-Ser catalytic triad embedded TAAHC-DIAL-GDSGGP motif, establishing as serine protease. Soluble recombinant GST-BmSP142 was expressed and purified, activity confirmed vitro. RT-qPCR results indicated mainly middle part of silkworm midgut, transcripts were significantly up-regulated at 24 hours post infection (hpi) BmBDV-resistant strains (798)...
ABSTRACT Mutations in the core protein (HBc) of hepatitis B virus (HBV) are associated with aggressive and advanced liver diseases chronic (CHB). In this study, we identified L60V variation HBc that generates a new HLA-A2-restricted CD8 + T cell epitope by screening an overlapping 9-mer peptide pool covering its variants. The nonameric V60 was determined structural immunogenic analysis. is correlated hepatic necroinflammation higher viral levels, it may be poor prognosis CHB patients....