A5100334370- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Lipid metabolism and disorders
- Respiratory viral infections research
- Cancer Treatment and Pharmacology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Nutritional Studies and Diet
- Pregnancy and preeclampsia studies
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Phytochemical and Pharmacological Studies
- HER2/EGFR in Cancer Research
- Virus-based gene therapy research
- Vitamin D Research Studies
- Viral gastroenteritis research and epidemiology
- Nutrition and Health in Aging
- Diet and metabolism studies
- Animal Virus Infections Studies
- Seaweed-derived Bioactive Compounds
- Viral Infections and Immunology Research
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
Peking University
2024-2025
Peking University Third Hospital
2025
Fujian Normal University
2024-2025
Kunming Medical University
2023-2025
Xidian University
2024-2025
Xi’an Jiaotong-Liverpool University
2025
Shihezi University
2021-2024
Macau University of Science and Technology
2024
Sun Yat-sen University
2024
Zhejiang University
2024
Public health officials and organizations have disseminated messages regarding the dangers of obesity, but these not produced desired effect.To estimate expected number years life lost (YLL) due to overweight obesity across span an adult.Data from (1) US Life Tables (1999); (2) Third National Health Nutrition Examination Survey (NHANES III; 1988-1994); (3) First Epidemiologic Follow-up Study I II; 1971-1992) NHANES II Mortality (1976-1992) were used derive YLL estimates for adults aged 18 85...
Pigs are considered as important hosts or "mixing vessels" for the generation of pandemic influenza viruses. Systematic surveillance viruses in pigs is essential early warning and preparedness next potential pandemic. Here, we report on an virus from 2011 to 2018 China, identify a recently emerged genotype 4 (G4) reassortant Eurasian avian-like (EA) H1N1 virus, which bears 2009 (pdm/09) triple-reassortant (TR)-derived internal genes has been predominant swine populations since 2016. Similar...
Adaptation of the viral polymerase complex comprising PB1, PB2, and PA is necessary for efficient influenza A virus replication in new host species. We found that mutation K356R (PA-K356R) has become predominant since 2014 avian H9N2 viruses China as with seasonal human H1N1 viruses. The same also most isolates emergent H7N9 H10N8 whose six internal gene segments are derived from virus. further demonstrated mammalian adaptive functionality PA-K356R mutation. Avian A549 cells showed increased...
Influenza H9N2 subtype viruses and their reassortants (such as H7N9) are posing increasing threats to birds humans in China. During 2009–2013, multiple novel with original genes emerged Yet, the genetic evolution of various host organisms China has not been systematically investigated since 2009. In present study, we performed large-scale sequence analysis viral genomes from public databases, representing spectrum isolated birds, mammals 1994 2013, updated clade classification for each...
ABSTRACT: Inhibin‐B is a heterodimeric glycoprotein produced by Sertoli cells. Although inhibin‐B levels are low when seminiferous tubules damaged, studies in normal monkeys reveal that also correlate positively with cell number. In this study, we measured healthy young adult men aged 18–24 years and prepubertal boys 5–9 relation to body mass index (BMI). declined increasing obesity men; values were 26% lower who obese compared normal‐weight men. Sex hormone—binding globulin total...
ABSTRACT Segment reassortment and base mutagenesis of influenza A viruses are the primary routes to rapid evolution high-fitness virus genotypes. We recently described a predominant G57 genotype avian H9N2 that caused countrywide outbreaks in chickens China during 2010 2013, which led zoonotic emergence H7N9 viruses. One key features is replacement earlier A/chicken/Beijing/1/1994 (BJ/94)-like M gene with A/quail/Hong Kong/G1/1997 (G1)-like quail origin. report here functional significance...
H9N2 Avian influenza virus (AIV) is regarded as a principal donor of viral genes through reassortment to co-circulating viruses that can result in zoonotic reassortants. Whether maintain sustained evolutionary impact on such reassortants unclear. Since 2013, avian H7N9 had caused five sequential human epidemics China; the fifth wave 2016-2017 was by far largest but mechanistic explanation behind scale infection not clear. Here, we found that, just prior epidemic, phylogenetically mutated...
Background/aim: Previous studies have suggested that the hepatic steatosis index (HSI) and fatty liver (FLI) can be used as a predictor of non-alcoholic disease (NAFLD).The aim our study was to determine whether non-invasive indices (HSI FLI) are associated with carotid atherosclerosis in type 2 diabetes mellitus (T2DM).Methods: This cross-sectional conducted T2DM patients (n=768).Carotid intima-media thickness (CIMT) measured by Color Doppler ultrasound.The HSI calculated based on gender,...
Abstract Purpose This investigation sought to examine the efficacy and safety of low-dose apatinib used alongside chemotherapy in clinical management patients with metastatic triple-negative breast cancer (TNBC) within a real-world setting, whilst comparing outcomes those treated solely chemotherapy. Methods case series study analyzed data treatment 163 TNBC who underwent rescue at Medical Oncology Department Clinical Oncology, Fujian Cancer Hospital, School University, China, between...
Purpose: Pain is a multidimensional, unpleasant emotional and sensory experience, accurately assessing its intensity crucial for effective management. However, individuals with cognitive impairments or language deficits may struggle to report their pain. EEG provides insight into the neurological aspects of pain, while facial EMG captures peripheral muscle responses. Our objective explore relationship between individual pain perception, brain activity, expressions through combined analysis...
Bromodomain-containing protein (BRD) play a pivotal role in the development and progression of malignant tumours. This study aims to identify prognostic genes linked BRD-related (BRDRGs) patients with triple-negative breast cancer (TNBC) construct novel model. Data from TCGA-TNBC, GSE135565, GSE161529 were retrieved public databases. was used key cell types. The BRDRGs score TCGA-TNBC calculated using single-sample Gene Set Enrichment Analysis (ssGSEA). Differential expression analysis...
Ammonia, traditionally recognized as a toxic nitrogen waste product, has recently emerged significant player in diverse physiological processes and implicated cancer biology. This review article provides an overview of the multifaceted impact ammonia on cellular signaling pathways, energy metabolism, tumor microenvironment dynamics, particular its novel roles neurotransmission, metabolic homeostasis, cell proliferation, immune modulation. Notably, accumulates within microenvironment,...
Background: Ovarian follicular cysts often resolve spontaneously, with giant forms being a rarity. Cases of ovarian in biological sisters without clear familial predisposition are even exceptional. Presentation: Two presented to our hospital large pelvic masses the setting clinical and hyperandrogenism. After surgical removal, pathology confirmed diagnosis cysts. Recurrence was detected shortly after surgery, both displaying similar courses. Chromosomal screening showed no abnormalities....
To evaluate the association between BMI (kg/m(2)) and headaches among women.Cross-sectional analysis of 11 datasets identified after searching for all large publicly available epidemiologic cohort study containing relevant variables. Datasets included National Health Interview Survey (NHIS): 1997-2003, first Examination Nutrition Survey, Alameda County Study (ACHS), Tecumseh Community (TCHS), Women's Initiative (WHI). The women (220,370 in total) were aged 18 years or older had reported...
Adaptation of PB2 protein is important for the establishment avian influenza viruses in mammalian hosts. Here, we identify I292V as prevalent mutation circulating H9N2 and pandemic H1N1 viruses. The same dominant also found most human isolates emergent H7N9 H10N8 In cells, PB2-292V virus has combined ability conferring higher viral polymerase activity stronger attenuation IFN-β induction than that its predecessor PB2-292I. accompanied by binding affinity host mitochondrial antiviral...
Neurotoxigenic Clostridium butyricum was isolated from the food implicated in an outbreak of clinically diagnosed type E botulism China. PCR assay showed that isolate (LCL 155) contained botulinum toxin gene. This appears to be first report neurotoxigenic C. causing food-borne botulism.