A5020493823- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Veterinary medicine and infectious diseases
- Coccidia and coccidiosis research
- Vector-Borne Animal Diseases
- Fungal and yeast genetics research
- Hepatitis Viruses Studies and Epidemiology
- 14-3-3 protein interactions
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Plant Virus Research Studies
- Microbial infections and disease research
- Toxin Mechanisms and Immunotoxins
- Toxoplasma gondii Research Studies
- Poxvirus research and outbreaks
- Vector-borne infectious diseases
- Plant and Fungal Interactions Research
Shandong Agricultural University
2015-2025
Kansas State University
2025
McGill University
2017
University of Liverpool
2015
Harbin Veterinary Research Institute
2007-2012
Chinese Academy of Agricultural Sciences
2007-2011
Rutgers New Jersey Medical School
1988
Rutgers, The State University of New Jersey
1988
Pigs are considered as important hosts or "mixing vessels" for the generation of pandemic influenza viruses. Systematic surveillance viruses in pigs is essential early warning and preparedness next potential pandemic. Here, we report on an virus from 2011 to 2018 China, identify a recently emerged genotype 4 (G4) reassortant Eurasian avian-like (EA) H1N1 virus, which bears 2009 (pdm/09) triple-reassortant (TR)-derived internal genes has been predominant swine populations since 2016. Similar...
Abstract Porcine reproductive and respiratory syndrome (PRRS) caused by the PRRS virus (PRRSV) is an important swine disease worldwide. PRRSV has a limited tropism for certain cells, which may at least in part be attributed to expression of necessary cellular molecules serving as receptors or factors on host cells binding entry. However, these conferring infection have not been fully characterized. Here we show identification non-muscle myosin heavy chain 9 (MYH9) essential factor using...
There have been many outbreaks of hydropericardium syndrome (HPS), which is characterized by pericardial effusion and hepatitis, in Chinese chicken farms since June 2015. HPS was mainly found miscellaneous meat-type chickens, Ma layer chicks Three-yellow while it occasionally white broilers. To determine the specific causative pathogen pathogenicity we collected 25 suspected cases performed clinical pathology aetiology analyses. The results showed that exhibited multifocal hepatitis with...
One hundred and five fowl adenovirus (FAdV) strains were isolated in China from 2015 to 2016 poultry with inclusion body hepatitis (IBH) hydropericardium syndrome (HPS). Polymerase chain reactions determined that 68 FAdV species C, D, two E, 30 contained or more different strains. A phylogenetic analysis showed the clustered into three major groups: FAdV-C, FAdV-D FAdV-E. Based on a hexon gene sequencing analysis, these viruses genetically related FAdV-4, FAdV-7, FAdV-8b FAdV-11, of which...
An epidemic that mainly endangered 3-7-day-old piglets struck many farms in Shandong Province, China 2013 and caused heavy losses. To identify the pathogenesis, type of lesions, causative agent, systemic examinations were performed. Autopsy showed multiple including necrotic foci spleen liver, punctate hemorrhage renal cortex, interstitial pneumonia. Histological typical nonsuppurative encephalitis, lymphocytes, reticuloendothelial cells lymphatic tissues, as well eosinophilic inclusion...
African swine fever is a highly transmissible and lethal infectious disease caused by the virus (ASFV), which has considerably impacted global industry. Lipid metabolism plays vital role in sustaining lipid energy homeostasis within cells influences viral life cycle. In this study, we found that ASFV infection disrupts host. Transcriptomic analysis of infected with revealed levels significantly changed as duration progressed. The intracellular cholesterol host exhibited pattern similar to...
Porcine reproductive and respiratory syndrome (PRRS) virus is a severe threat to the global swine industry. Modified live vaccines (MLVs) for two PRRSV species (PRRSV-1 PRRSV-2) are most widely used approach control PRRSV-caused diseases. For herds influenced by PRRSV-1 PRRSV-2, how rationalize MLV immunization strategies robust cross-protective immune responses has been long-lasting need. In this study, we found that replication of strongly suppressed co-infection with PRRSV-2 in vitro,...
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most harmful pathogens in swine industry. Our previous studies demonstrated that small extracellular domain (ECL2) CLDN4 effectively blocks PRRSV infection. In this study, we explored vivo administration ECL2 (sECL2) found it blocked HP-PRRSV infection alleviated histopathological changes organs. Notably, sECL2 stimulated cytokine production lungs. We observed upregulated expression IFN-β at low doses GP3....
Classical swine fever virus (CSFV) causes an economically important and highly contagious disease of pigs worldwide. C-strain vaccination is one the most effective ways to contain this disease. Since 2014, sporadic CSF outbreaks have been occurring in some vaccinated provinces China. To decipher etiology, 25 CSFV E2 genes from 169 clinical samples were cloned sequenced. Phylogenetic analyses revealed that all isolates belonged subgenotype 2.1. Twenty-three clustered a newly defined...
Abstract Background The global pork industry is continuously affected by infectious diseases that can result in large-scale mortality, trade restrictions, and major reductions production. Nevertheless, the cause of many pigs remains unclear, largely because commonly used diagnostic tools fail to capture full diversity potential pathogens pathogen co-infection common. Results We a meta-transcriptomic approach systematically characterize 136 clinical cases representing different disease...
Florfenicol (FLO) is one of the most popular antibiotics used in veterinary clinic and aquaculture. FLO can inhibit both bacterial mitochondrial protein synthesis. However, effects on function cellular homeostasis remain unclear. Here we show that inhibits expression DNA-encoded proteins, decreases membrane potential, promotes generation reactive oxygen species (ROS) vitro. As a result, activities respiratory chain complex I IV ATP level are decreased morphology damaged. represses cell...
In late 2011, a variant pseudorabies virus (vPRV) emerged in Bartha-K61-vaccinated pig herds, resulting high morbidity and mortality of piglets China. Since 2013, the autopsy lesions, histological examinations, isolation, phylogenetic analysis selection pressure gE gene vPRV were recorded for 395 clinical cases, 5,033 serum samples detected by PRV gE-coated enzyme-linked immunosorbent assay. The major symptoms abortion pregnant sows, fatal neurological signs respiratory disease growing pigs....
African swine fever (ASF) caused by ASF virus (ASFV) is a fatal disease in pigs and results great economic losses. Due to the lack of available vaccines treatments, serological diagnosis plays key role surveillance program, but due knowledge complexity ASFV genome, candidate target viral proteins are still being researched. False negativity big obstacle during diagnostic process. In this study, high antigenic p30, p54 p72 were screened find dominant domains tandem His–p30–54–72 was derived....
To elucidate the effect of fowl adenovirus (FAdV)-C in specific-pathogen-free (SPF) chickens, we investigated pathogenicity, body weights, enzymatic systems, and immune organs chickens response to Newcastle disease virus (NDV) avian influenza subtype H9 (AIV-H9) vaccination. Chickens were divided randomly into four groups, which included injection groups (FAdV-C, vaccination, FAdV-C plus vaccination) a negative control group. The results indicated that was highly pathogenic SPF led 40%...
Abstract Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is one of the most severe swine diseases that affects almost all swine-breeding countries. Nonstructural protein 2 (NSP2) important viral proteins in PRRSV life cycle. Our previous study showed NSP2 could induce formation aggresomes. In this we explored effects aggresome on cells found autophagy, which depended to activate aggrephagy. The transmembrane tail domains contributed aggrephagy cellular...