A5100379147- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Toxin Mechanisms and Immunotoxins
- Plant Virus Research Studies
- Pharmacological Effects of Natural Compounds
- Respiratory viral infections research
- Food Quality and Safety Studies
- Plant biochemistry and biosynthesis
- Traditional Chinese Medicine Analysis
- COVID-19 Clinical Research Studies
- Vector-Borne Animal Diseases
- Natural product bioactivities and synthesis
- Click Chemistry and Applications
- Mass Spectrometry Techniques and Applications
- Ginseng Biological Effects and Applications
- Fermentation and Sensory Analysis
- Immune Cell Function and Interaction
- Proteins in Food Systems
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Pickering emulsions and particle stabilization
- RNA and protein synthesis mechanisms
- Children's Physical and Motor Development
South China Agricultural University
2010-2025
Key Laboratory of Guangdong Province
2020-2024
Fujian Normal University
2022
Netherlands Organisation for Applied Scientific Research
2022
Medical University of Silesia
2022
Noldus Information Technology
2022
University of Aberdeen
2022
Institut Superieur de l'Aeronautique et de l'Espace (ISAE-SUPAERO)
2022
University of Lausanne
2022
Sorbonne Université
2022
The influenza virus nucleoprotein (NP) is an emerging target for anti-influenza drug development. Nucleozin (1) and its closely related derivatives had been identified as NP inhibitors displaying activity. Utilizing 1 a lead molecule, we successfully designed synthesized series of 1H-1,2,3-triazole-4-carboxamide new A agents. One the most potent compounds, 3b, inhibited replication various H3N2 H1N1 strains with IC50 values ranging from 0.5 to 4.6 μM. Compound 3b also strongly H5N1 (RG14),...
ABSTRACT Rationale Protopine, an active alkaloid in Papaver somniferum L., was abundant a well‐known anticough traditional Chinese medicine preparation—Zhi‐Ke‐Bao tablets. Till now, the metabolism feature and mechanism of protopine have not been fully elucidated, restricting its further development. Methods The metabolites rats were profiled by using ultra‐high performance liquid chromatography coupled with time‐of‐flight mass spectrometry, targets predicted network pharmacology. Results In...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a widely prevalent endemic swine pathogen that causes significant economic losses for the global pig industry annually. Currently, most strategy PRRSV control remains prevention of transmission, with highly effective therapeutic agents vaccines still lacking. Proanthocyanidin A2 (PA2) belongs to family tea polyphenols, which have been reported exhibit range biological activities including anti-oxidative, cardio-protective,...
Abstract Background The global pork industry is continuously affected by infectious diseases that can result in large-scale mortality, trade restrictions, and major reductions production. Nevertheless, the cause of many pigs remains unclear, largely because commonly used diagnostic tools fail to capture full diversity potential pathogens pathogen co-infection common. Results We a meta-transcriptomic approach systematically characterize 136 clinical cases representing different disease...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a continuous threat to the pork industry as it continues cause significant economic loss worldwide. Currently, vaccination strategies provide very limited protection against PRRSV transmission. Consequently, there an urgent need develop new antiviral strategies. Platycodin D (PD) one of major bioactive triterpenoid saponins derived from Platycodon grandiflorum, traditional Chinese medicine used expectorant for pulmonary diseases...
A method based on accelerated solvent extraction combined with rapid-resolution LC-MS for efficient extraction, rapid separation, online identification and accurate determination of the saikosaponins (SSs) in Radix bupleuri (RB) was developed. The RB samples were extracted by using 70% aqueous ethanol v/v as solvent, at a temperature 120 degrees C pressure 100 bar, 10 min static time three cycles. Rapid-resolution LC separation performed C(18) column gradient elution water (containing 0.5%...
Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses to the pork industry worldwide. Currently, vaccine strategies provide limited protection against PRRSV transmission, no effective drug is commercially available. Therefore, there an urgent need develop novel antiviral prevent pandemics. This study showed that artesunate (AS), one of antimalarial drugs, potently suppressed replication in Marc-145 cells ex vivo primary porcine alveolar macrophages...
Influenza A virus (IAV) infections have been a serious hazard to public health everywhere. With the growing concern of drug-resistant IAV strains, there is an urgent need for novel anti-IAV medications, especially those with alternative mechanisms action. Hemagglutinin (HA), glycoprotein, plays critical roles in early stage infection, including receptor binding and membrane fusion, making it good target developing drugs. Panax ginseng widely used herb traditional medicine extensive...
Influenza A viruses (IAV) have been a major public health threat worldwide, and options for antiviral therapy become increasingly limited with the emergence of drug-resisting virus strains. New effective anti-IAV drugs, especially highly pathogenic influenza, different modes action, are urgently needed. The influenza glycoprotein hemagglutinin (HA) plays critical roles in early stage infection, including receptor binding membrane fusion, making it potential target development anti-influenza...
African swine fever virus (ASFV) is a highly infectious and lethal pathogen that causes severe socio-economic consequences in affected countries. Unfortunately, effective vaccine for combating ASF unavailable so far, the prevention control strategies ASFV are still very limited. Toosendanin (TSN), triterpenoid saponin extracted from medicinal herb Melia toosendan Sieb. Et Zucc, has been demonstrated to possess analgesic, anti-inflammatory, anti-botulism anti-microbial activities, was used...
Influenza PAN inhibitors are of particular importance in current efforts to develop a new generation antiviral drugs due the growing emergence highly pathogenic influenza viruses and resistance existing inhibitors. Herein, we design synthesize set 1,3-cis-N-substituted-1,2,3,4-tetrahydroisoquinoline derivatives enhance their potency by further exploiting pockets 3 4 endonuclease based on hit d,l-laudanosoline. Particularly, lead compound 35 exhibited potent broad anti-influenza virus effects...
Abstract An improved and convenient synthetic route for the synthesis of peramivir has been developed with a total 34% yield. The process was from previous methods in three key reaction steps including 1,3-dipolar cycloaddition, reductive ring cleavage isoxazoline, incorporation peripheral guanidino group. First, an activated sodium hypochlorite (Cl% = 10%) employed catalytic 61–68% yields were obtained. Second, NaBH4-NiCl2 used as new reducing reagent instead expensive catalyst PtO2. Most...
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is a prevalent endemic swine pathogen which causes significant economic losses in the global industry. Multiple vaccines have been developed to prevent PRRSV infection. However, they provide limited protection. Moreover, no effective therapeutic drugs are yet available. Therefore, there an urgent need develop novel antiviral strategies infection transmission. Here we report that Toosendanin (TSN), tetracyclic triterpene...
Background: Ganoderma lucidum, which is widely used as “Ganoderma” in China or other Asian countries (Japan, Korea, etc), exerts an important role tonifying qi and calming the mind clinical applications. Triterpenoids are main active components with significant biological activities of hepatoprotective, anticancer, anti-tumor, etc. However, current analysis triterpenoids lucidum by mass spectrometry limited, restricting its quality control elucidation functional basis. Objective: This work...