A5068193499- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Remote-Sensing Image Classification
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Influenza Virus Research Studies
- Infrared Target Detection Methodologies
- MicroRNA in disease regulation
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Axon Guidance and Neuronal Signaling
- Cancer Mechanisms and Therapy
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Turbomachinery Performance and Optimization
- Digital Media Forensic Detection
- Advanced Steganography and Watermarking Techniques
- Retinoids in leukemia and cellular processes
Southern Medical University
2021-2025
Shandong Provincial Hospital
2014-2025
Shandong First Medical University
2020-2025
Liaocheng People's Hospital
2013-2024
Shandong University
2010-2023
Beihang University
2014-2023
University of Pennsylvania
2023
Guangdong Provincial Center for Disease Control and Prevention
2022
California University of Pennsylvania
2022
Beijing Normal University
2022
Gastric cancer (GC) is a leading cause of deaths, and an increased number GC patients adopt to next-generation sequencing (NGS) identify tumor genomic alterations for precision medicine.In this study, we established hybridization capture-based NGS panel including 612 cancer-associated genes, collected data tumors matched bloods from 153 gastric patients. We performed comprehensive analysis these clinical data.35 significantly mutated genes were identified such as TP53, AKAP9, DRD2, PTEN,...
Defect detection of petrochemical pipelines is an important task for industrial production safety. At present, pipeline defect mainly relies on closed circuit television method (CCTV) to take video the inner wall and then detect defective area manually, so very time-consuming has a high rate false missed detections. To solve above issues, we proposed automatic system based Cycle-GAN improved YOLO v5. Firstly, in order create dataset, original videos need pre-processing, which includes frame...
Integrin alpha v beta 6 (alpha 6) is correlated with colon cancer progression. To detect the effects of on liver metastasis, specificity against monoclonal antibody (mAb) 2G2 was examined by immunoprecipitation. 6-immunoreactivity (IR) in metastasis tissues (63 cases) and carcinoma (358 were examined. These results showed that specifically recognized mAb 2G2, rates positivity metastatic (71.4%, 45/63) higher than for primary (34.0%, 122/358) (P < 0.01). Patients who 6-positive had (17%,...
The serum level of soluble CD44 is directly associated with several clinicopathological parameters malignant diseases. There a great need for the development an easy and cost-effective detection method both diagnosis treatment cancers. In this work, simple photoelectrochemical (PEC) sensitive serum-soluble proposed based on construction hybrid antifouling coating TiO2 substrate. Hyaluronic acid (HA) poly(ethylene glycol) (PEG) are co-immobilized using biomimetic one-step surface...
483 Background: Heterogeneity exists in recurrence and survival among patients with intestinal-type gastric cancer (IGC). Nucleotyping is the alterations chromatin organization. We sought to identify prognostic utility of nucleotyping, tumor stroma ratio (TSR) DNA ploidy these patients. Methods: Radical resection carcinoma (> 15 LNs removed) was performed 283 (stage I, n=73; stage II, n=102; III, n=108) at our university hospital between 2010 2018. Automated image cytometry tools were...
484 Background: The histopathological growth patterns (HGPs) of liver metastasis reflect the complicated and varied interactions between tumor cells host microenvironment. We studied HGPs gastric cancer (GCLM) sought to predict them using radiomic clinical variables. Methods: Hepatectomy was performed in 62 patients with GCLM at our university hospital 2011 2021. were evaluated according international consensus guidelines, classified as either desmoplastic HGP (dHGP) or non-dHGP. CD4, CD8,...
AIM:To evaluate the biological and clinical characteristics of miR-622 in gastric cancer. METHODS:We analyzed expression 57 pair matched neoplastic adjacent non-neoplastic tissues by quantitative real-time polymerase chain reaction.Functional analysis was assessed vitro cancer cell lines with precursor inhibitor.The roles tumorigenesis tumor metastasis were using a stable plasmid nude mice.A luciferase reporter assay used to assess effect on inhibitor growth family, member 1 (ING1)...
Chlamydia is common among women of reproductive age and can cause serious health issues. This study aimed to examine the trends factors linked newly diagnosed reported chlamydia cases in aged 15-49 Guangdong Province from 2006 2020. We included all January 1, 2006, December 31, Data 21 cities were sourced National Notifiable Infectious Disease Reporting Information System China. Temporal analyzed using Joinpoint regression models. City-level (population density, net migration rate,...
Previous studies have shown that Atp6v1c1, a regulator of the assembly V0 and V1 domains V-ATPase complex, is up-regulated in metastatic oral tumors.Despite these studies, function Atp6v1c1 tumor growth metastasis still unknown.Atp6v1c1's expression squamous cell carcinoma indicates has an important cancer metastasis.We hypothesized elevated essential to promotes through activation activity.To test this hypothesis, Lentivirus-mediated RNAi knockdown approach was used study mouse 4T1 mammary...
Abstract Hierarchical organization of intestine relies on the self-renewal and tightly regulated differentiation intestinal stem cells (ISCs). Although signals like Wnt are known to sustain continued renewal by maintaining ISCs activity lineage commitment, molecular mechanisms underlying ‘stemness’ supportive niche have not been well understood. Here, we found that CUL4B-RING ubiquitin ligase (CRL4B) regulates homeostasis targeting immunity-related GTPase family M member 1 (IRGM1) for...
Abstract Background Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). The limited treatment options for LN increase economic burdens on patients. Because fibrotic progression leads to irreversible renal damage in patients and further progresses chronic kidney disease (CKD) end stage (ESRD), developing new targets prevent could lead a feasible strategy Methods In this study, we examined YAP activation LATS2 downregulation biopsy samples (LN: n = 8,...
Previous studies have shown that the rate of breast cancer metastasis correlates with expression vacuolar H+-ATPases (V-ATPases). However, how V-ATPase is involved in remains unknown. Our previous study showed Atp6v1c1-depleted osteoclasts did not form organized actin rings and Atp6v1c1 co-localizes F-actin. In this study, we found normal arrangement filamentous disrupted 4T1 mouse cells ATP6V1C1-depleted human cell lines MDA-MB-231 MDA-MB-435s. We further F-actin cells. The results our...
Abnormal expression of microRNA-21 (miR-21) is considered to be closely associated with the pathogenesis colorectal cancer. However, great challenges do exist for development ultra-sensitive biosensors detect abnormal miR-21 due low concentration in serum (fm level) at early stage Therefore, electric field force used rotate and rearrange random multi-walled carbon nanotubes (MWCNTs) microscale improve active sites electrode this study. The free-standing MWCNTs are densely high-orderly...
AIM:To investigate semaphorin 4D (Sema4D) and hypoxia-inducible factor-1α (HIF-1α) expression in colorectal carcinoma evaluate their clinicopathological prognostic significance.
Colorectal cancer is one of the most common cancers worldwide in terms both incidence and mortality. The associations expressions tissue plasma miR-29b were not detected this study.There are 400 healthy age- gender-matched controls enrolled study a rate 1:2. receiver operating characteristic curve analysis was undertaken using expression level for colorectal specimens from patients with to assess diagnostic accuracy levels.It found that associated miR-29b. Advanced showed aberrant tissues...
To study the role of semaphorin 4D (Sema4D) expression promoted by tumor-associated macrophages (TAMs) in gastric carcinoma cells and its clinical significance invasion metastasis carcinoma.CD68 Sema4D was analyzed adjacent normal tissues from 290 patients using immunohistochemical streptavidin-peroxidase method, their relationships with clinicopathological features were evaluated. Human M2 induced vitro co-cultured non-contact SGC-7901 cells. Changes secretory level cell supernatant...
Abstract As oncogenes and tumor suppressor genes, long non-coding RNAs (lncRNAs) regulate the biological behavior of gastric cancer (GC) cells such as proliferation, invasion, metastasis through various signal pathways. At present, although numerous lncRNAs that significantly influence development progression GC have been identified, a considerable number them not found studied yet. In this study, we identified new lncRNA derived from pseudogenes WFDC21P, which reported in any previous...
The immune escape of colon cancer and its role in the response to immunotherapies such as PD-1/PD-L1 checkpoint inhibitors have long been great interest. positive outcomes immunotherapy are limited by immunosuppressive nature tumor microenvironment. Integrin αvβ6, which can regulate progression cancer, was recently reported be involved suppression cancer. In present study, we explored correlation between αvβ6 PD-L1 expression immunohistochemistry tissues. Then, regulation signaling cells...