A5101739882- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- Cardiovascular Effects of Exercise
- Cardiac Ischemia and Reperfusion
- Sirtuins and Resveratrol in Medicine
- Congenital Heart Disease Studies
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Heart Rate Variability and Autonomic Control
- Sepsis Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cardiac Arrhythmias and Treatments
- SARS-CoV-2 and COVID-19 Research
- Cardiac Valve Diseases and Treatments
- Acupuncture Treatment Research Studies
- Calcium signaling and nucleotide metabolism
- Metabolism and Genetic Disorders
- Thermal Regulation in Medicine
- Traditional Chinese Medicine Studies
- Galectins and Cancer Biology
- Cardiac tumors and thrombi
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Central South University
2020-2024
Xiangya Hospital Central South University
2020-2024
Second Hospital of Shandong University
2016-2024
Jilin University
2002-2024
Affiliated Hospital of Jining Medical University
2023
Dalian University of Technology
2023
Beijing Hospital
2020-2023
Shandong University
2013-2022
Weifang Medical University
2022
Idebenone, an antioxidant used in treating oxidative damage-related diseases, has unclear neuroprotective mechanisms. Oxidative stress affects cell and mitochondrial membranes, altering Adp-ribosyl cyclase (CD38) Silent message regulator 3 (SIRT3) protein expression possibly impacting SIRT3's ability to deacetylate Tumor p53 (P53). This study explores the relationship between CD38, SIRT3, P53 H
Colorectal cancer is one of the most common cancers worldwide in terms both incidence and mortality. The associations expressions tissue plasma miR-29b were not detected this study.There are 400 healthy age- gender-matched controls enrolled study a rate 1:2. receiver operating characteristic curve analysis was undertaken using expression level for colorectal specimens from patients with to assess diagnostic accuracy levels.It found that associated miR-29b. Advanced showed aberrant tissues...
Trastuzumab resistance is a major obstacle encountered in human epidermal growth factor receptor 2 (HER2)-positive breast cancer therapy. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles both tumorigenesis and tumor development. However, whether lncRNAs are associated with trastuzumab not yet clear.We evaluated sensitivity cell lines, SKBR3, HCC1954, MDA-MB-231. We also H19 expression these lines after treatment different concentrations. Besides, was downregulated...
Abstract: Dabigatran is a novel direct oral anticoagulant agent, whose plasma concentration closely related to bleeding risk. Genetic polymorphisms can affect the level of dabigatran. The purpose this study was understand relationship between dabigatran-related genes and dabigatran in healthy Chinese subjects after taking single dose. This performed with single-center, single-dose, randomized, open-label, four-period crossover trial design under both fasting fed conditions. A total 106...
Objective: Myocardial work (MW) is a novel non-invasive method that uses speckle tracking echocardiography (STE) to assess left ventricular (LV) function. MW incorporates the global longitudinal strain and afterload conditions. Here we aimed use LV function of patients with coronary artery disease (CAD) or without heart failure (HF). Methods: We enrolled total 150 individuals (50 each) CAD normal ejection fraction (LVEF), HF, healthy controls. Patients were divided into hypertension (HTN)...
ObjectivesWe aimed to identify the major determinants of cardiac troponin changes response exercise among non-elite runners participating in Beijing 2022 marathon, with a particular focus on associations function assessed by tissue Doppler echocardiography and speckle tracking.DesignA prospective study.MethodsA total 33 participants Marathon were included study. Echocardiographic assessment blood sample collection conducted before, immediately after, two weeks after marathon. Blood samples...
This study is to assess the diagnostic value of noninvasive regional myocardial work (MW) by echocardiography for detecting functional status coronary stenosis using fractional flow reserve (FFR) as a standard criterion. A total 84 consecutive patients were included in this study, among which 92 vessels identified with ≥50% confirmed invasive angiography. Patients investigated FFR and transthoracic echocardiography. Regional MW indices including index (MWI), constructive (MCW), wasted work,...
BackgroundThe formation of pyrrole adducts might be responsible for peripheral nerve injury caused by n-hexane. The internal dose would supply more information the neurotoxicity current study was designed to investigate tissue distributions 2, 5-hexanedione (2,5-HD) and in rats exposed n-hexane, analyze correlation between 2,5-HD tissues. MethodsMale Wistar were given daily 500,1000, 2000, 4000 mg/kg bw n-hexane gavage 5 days. sacrificed 24 hours after last administration. levels tissues...
Hyperlipidemia is a risk factor for cardiac damage and cardiovascular disease. Increasing evidence has shown that dyslipidemia‐related associated with lipid accumulation, oxidative stress, inflammation. Thymoquinone (TQ) the major constituent of Nigella sativa , commonly known as black seed or cumin, globally used in folk (herbal) medicine treating preventing number diseases conditions. Several studies have TQ can protect against damage. This study aimed at investigating possible protective...
Background The prognostic value of N-terminal pro-brain natriuretic peptide ( NT -pro BNP ) in patients with hypertrophic cardiomyopathy who underwent septal myectomy has not been well studied. Methods and Results We retrospectively evaluated levels 758 (46.1±13.8 years; median follow-up, 936 days) our center between March 2011 April 2018. level was 1450.5 (interquartile range 682.6-2649.5) pg/mL. Overall, 22 (2.9%) died during follow-up; these, 86.4% were cardiovascular deaths. 3-year...
Background/Aims: We aimed to evaluate the distribution of abnormal liver-related biomarkers in patients with coronavirus disease (COVID-19) and explore prognostic value elevated liver enzymes synthetic capacity regards patient mortality. Patients Methods: This retrospective observational study included 80 laboratory-confirmed COVID-19 cases. Data were collected from electronic medical record system by a trained team physicians. Alanine aminotransferase (ALT), aspartate (AST), total bilirubin...
Abstract Background The ongoing worldwide epidemic of Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2), has posed a huge threat to global public health. However, with regard the effects inflammatory markers on severity COVID-19, studies have reported associations that vary in strength and direction. Aims In meta-analysis, we aimed provide an overview association COVID-19. Methods following databases were searched: PubMed, Embase,...
Atrial fibrillation (AF) is the most common cardiac arrhythmia. The effectiveness and mechanism of edoxaban in preventing stroke after atrial remain unclear.
Pyrrole adducts might be used as a biomarker for monitoring occupational exposure to n-hexane, but the Biological Exposure Indices of pyrrole in serum and urine are still unknown. The current study was designed investigate biological limit hazard assessment n-hexane.Male Wistar rats were given daily dose 500, 1000, 1500, 2000, 4000 mg/kg bw n-hexane by gavage 24 weeks. levels determined at 8, hours postdose once week. evaluated neurological evaluation adducts. difference formation between...
To investigate the effect of acupuncture at PC6 on cardiac hypertrophy in isoproterenol (ISO)-treated mice.48 male C57BL/6 mice underwent subcutaneous injection ISO for 14 days and were randomly divided into four groups (n=12 each) that remained untreated (ISO group), received verum manual (MA) treatment (ISO+MA(PC6) sham MA location tail not corresponding to any traditional point (ISO+MA(tail) or propranolol (ISO+PR group). An additional 12 given an phosphate-buffered saline (PBS) formed a...