A5101520074- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Bariatric Surgery and Outcomes
- RNA modifications and cancer
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Cancer Mechanisms and Therapy
- Metastasis and carcinoma case studies
- Cholesterol and Lipid Metabolism
- Axon Guidance and Neuronal Signaling
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Body Contouring and Surgery
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
Tan Tock Seng Hospital
2025
Changchun University of Chinese Medicine
2024-2025
Hangzhou City University
2024
Second Military Medical University
2015-2024
Changhai Hospital
2014-2024
Jiangsu University
2018-2023
Yangzhou University
2017-2023
Affiliated Hospital of Jiangsu University
2018-2023
Beijing Jiaotong University
2023
Taixing People's Hospital
2016-2020
Gastric cancer (GC) is a leading cause of deaths, and an increased number GC patients adopt to next-generation sequencing (NGS) identify tumor genomic alterations for precision medicine.In this study, we established hybridization capture-based NGS panel including 612 cancer-associated genes, collected data tumors matched bloods from 153 gastric patients. We performed comprehensive analysis these clinical data.35 significantly mutated genes were identified such as TP53, AKAP9, DRD2, PTEN,...
<h3>Background</h3> Inhibitors targeting VEGF and VEGFR are commonly used in the clinic, but only a subset of patients could benefit from these inhibitors efficacy was limited by multiple relapse mechanisms. In this work, we aimed to investigate role innate immune response anti-angiogenic therapy explore efficient therapeutic strategies enhance against non-small cell lung cancer (NSCLC). <h3>Methods</h3> Three NSCLC tumor models with responses were designed determine immune-related...
Previous reports have shown a mutual negative feedback loop between microRNA (miR)-206 and estrogen receptor (ER) expression. Furthermore, decreased miR-206 expression in breast cancer (BC) is associated with the advanced clinical stage lymph node metastasis. However, its role mechanism underlying migration invasion of ER positive BC remain unclear.In this study, was stably transfected into cell lines MCF-7 T47D to investigate effect miR-206. The results showed that overexpression markedly...
Abstract Increasing evidence indicates that dysregulation of microRNAs (miRNAs) plays a crucial role in human malignancies. Here, we showed microRNA-422a (miR-422a) expression was dramatically downregulated gastric cancer (GC) samples and cell lines compared with normal controls, its level inversely related to tumor size depth infiltration. Functional studies revealed the overexpression miR-422a GC cells suppressed proliferation migration, drove metabolic shift from aerobic glycolysis...
Abstract Background CD47, serving as an intrinsic immune checkpoint, has demonstrated efficacy anti-tumor target in hematologic malignancies. Nevertheless, the clinical relevance of CD47 gastric cancer and its potential a therapeutic remains unclear. Methods The expression tissues was assessed using immunohistochemistry Western blot. Patient-derived cells were obtained from co-cultured with macrophages derived human peripheral blood mononuclear cells. Flow cytometry analyses employed to...
Abstract Hepatic de novo lipogenesis (DNL) converts carbohydrates into triglycerides and is known to influence systemic lipid homoeostasis. Here, we demonstrate that the zinc finger protein Zbtb20 required for DNL. Mice lacking in liver exhibit hypolipidemia reduced levels of triglycerides, along with impaired hepatic lipogenesis. The expression genes involved glycolysis DNL, including two ChREBP isoforms, decreased livers knockout mice. binds enhances activity ChREBP-α promoter, suggesting...
The ectonucleotidase CD73 degrades adenosine triphosphate (ATP) to which potently inhibits host immune responses against cancer. This study investigated the expression level and prognostic significance of in human rectal adenocarcinoma. Our data demonstrated that staining strongly marked both malignant epithelial cells stromal components where protein messenger RNA (mRNA) levels were significantly increased compared with paracancerous controls. High tumor can be used as an independent factor...
Research indicates that there may be an association between plasma lipidome levels and the incidence of diabetic retinopathy (DR) in patients. However, potential causality this relationship is yet to determined. To investigate matter further, we employed a two-sample Mendelian randomization (MR) analysis comprehensively assess DR. Summary statistics for lipid DR were obtained from Genome-Wide Association Studies (GWAS) Catalog database FinnGen Consortium, respectively. We conducted MR...
Protein-tyrosine phosphatase MEG2 (MEG2) is a classic tyrosine-specific protein tyrosine (PTP). It has been reported that participates in the carcinogenesis of breast and liver. However, functions gastric cancer remain poorly understood. We examined expression by western blotting miR-181a-5p qRT-PCR. used bioinformatic analyses to search for miRNAs potentially target MEG2. performed luciferase reporter assay investigate interaction between In addition, we assessed effects on cells vitro...
Abstract Objectives Gastric cancer (GC) is one of the most common cancers in world, causing a large number deaths every year. The Slit‐Robo signalling pathway, initially discovered for its critical role neuronal guidance, has recently been shown to modulate tumour invasion and metastasis several human cancers. However, molecular mechanisms underlying pathogenesis gastric remains be elucidated. Materials methods Slit2, Robo1 USP33 expressions were analysed datasets obtained from Oncomine...
// Kai Yin 1, 2, 3, * , Minghui Liu Mei Zhang 4, Feng Wang Min Fen 1 Zhijian 5 Yutao Yuan Shanting Gao Liuqing Yang Weijie Jianguo 6 Baoliang Guo Jianwei Xu 3 Hongwei Liang 2 Xi Chen Wenxian Guan Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital Clinical College Medical University, Nanjing, Jiangsu 210008, China State Key Laboratory Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), Engineering Research Center MicroRNA Biology and School...
Long non-coding RNAs (lncRNAs) have been demonstrated to participate in many biological processes and severs as important regulators during the progression of gastric cancer.Here, we introduced human lncRNA SNHG15 which was highly expressed cancer cells. Interestingly, expression correlated with programmed cell death ligand 1 (PD-L1), promotes resistance cells immune responses. Meanwhile, downregulation suppressed PD-L1 responses.Further, our results suggested that acted a competing...
Laparoscopic sleeve gastrectomy (LSG) is becoming a stand-alone bariatric surgery for obesity, but its effectiveness Mainland Chinese patients remains unclear.To evaluate the and safety of LSG SETTING: A tertiary hospital METHODS: Retrospective analysis admitted between January 2011 February 2012 was performed. Medium-term outcome measures were: total weight loss (%TWL), excess (%EWL), co-morbidities, improvement, complications.Seventy (body mass index [BMI] 40.8±5.9 kg/m2) underwent LSG,...
Abstract Success in curing breast cancer largely depends on the stage at diagnosis. Circulating microRNAs are becoming a promising noninvasive biomarker. We postulate that postoperative decline circulating might have diagnostic and prognostic value. Applying high-throughput microarrays, we screened dysregulated paired serum samples before after surgery. The relative concentrations of putative markers between early cancer-free groups were evaluated training set verified validation set....
Abstract Trastuzumab emtansine (T-DM1), an antibody-drug conjugate consisted of the HER2-targeted monoclonal antibody trastuzumab and tubulin inhibitor emtansine, has shown potent therapeutic value in HER2-positive breast cancer (BC). However, a clinical trial indicated that T-DM1 exerts limited effect on gastric (GC), but underlying mechanism is inconclusive. Our research attempted to reveal probable role autophagy T-DM1-treated GC. In this study, our results showed induced apoptosis...
Abstract The nuclear paraspeckle assembly transcript 1 (abbreviated as NEAT1), a sufficient long noncoding RNA lncRNA), has aroused rising concern in recent years. As uncovered by reports, the increase NEAT1 is related to deteriorated prognosis of lung cancer, breast hepatocellular and colorectal cancer CRC). Thus far, mechanism not been elucidated existing researches. impact knockdown both its predicted downstream miR‐193a‐3p CRC cells was examined here delve into their interactions...
Abstract Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, severe cases, failure. The side effects of current treatments, such as hormone therapy, drugs, radiotherapy, highlight need for new therapeutic strategies. Traditional Chinese Medicine (TCM) offers a promising alternative, leveraging its ability target multiple pathways mechanisms. Active compounds from herbs other natural sources exhibit...
Background: The aims of this study were to determine whether the quantitative HER2 gene amplification level is related key clinicopathological features that represent aggressiveness breast cancer (BC) and could predict treatment response in subset HER2-positive patients who received neoadjuvant targeted therapy. Materials methods: Patients treated with weekly cisplatin- paclitaxel-based chemotherapy, had undergone both immunohistochemistry fluorescence situ hybridization test for , included...