A5044390408- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Renal Diseases and Glomerulopathies
- Peroxisome Proliferator-Activated Receptors
- Cancer-related Molecular Pathways
- Muscle and Compartmental Disorders
- Psoriasis: Treatment and Pathogenesis
- Heme Oxygenase-1 and Carbon Monoxide
- Eicosanoids and Hypertension Pharmacology
- Drug-Induced Hepatotoxicity and Protection
- Nephrotoxicity and Medicinal Plants
- Neurological and metabolic disorders
- Biomedical Ethics and Regulation
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Biomarkers in Disease Mechanisms
- Sulfur Compounds in Biology
- Venomous Animal Envenomation and Studies
- Childhood Cancer Survivors' Quality of Life
- Dermatological and Skeletal Disorders
- Ginseng Biological Effects and Applications
- Hematopoietic Stem Cell Transplantation
- Liver Disease Diagnosis and Treatment
Second Military Medical University
2014-2024
Changhai Hospital
2013-2024
Shanghai Pudong New Area Gongli Hospital
2022
Cellular Research (United States)
2017
Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is acknowledged as an independent risk factor for cardiovascular which underlines urgent need new medications to DN. Dihydroquercetin (DHQ), important natural dihydroflavone, exerts significant antioxidant, anti-inflammatory, and antifibrotic properties, but its effects on DN have not been investigated yet.We aimed explore kidney protection DHQ rats induced by high-fat diet/streptozotocin in vivo underlying mechanisms...
Diabetic nephropathy (DN) is one of the most lethal complications diabetes mellitus with metabolic disorders and chronic inflammation. Although cytokine IL-22 was initially implicated in pathogenesis inflammatory diseases, recent studies suggested that could suppress responses alleviate tissue injury. Herein, we examined role DN. We found serum levels were significantly downregulated both patients mice The expression further decreased progression DN, whereas gene therapy ameliorated renal...
<h3>Background</h3> Inhibitors targeting VEGF and VEGFR are commonly used in the clinic, but only a subset of patients could benefit from these inhibitors efficacy was limited by multiple relapse mechanisms. In this work, we aimed to investigate role innate immune response anti-angiogenic therapy explore efficient therapeutic strategies enhance against non-small cell lung cancer (NSCLC). <h3>Methods</h3> Three NSCLC tumor models with responses were designed determine immune-related...
Nonalcoholic fatty liver disease (NAFLD) is now a leading cause of chronic disease, and there currently no available treatment strategy. Interleukin-22 (IL-22) has been recognized as promising agent for alleviating NAFLD, but the efficacy IL-22 far from satisfactory because safe dose elicited limited improvement, whereas higher concentration might induce serious side effects off-target toxicities. Thus, targeted sustained expression in necessary. To meet challenge, we elaborately developed...
Diabetic nephropathy (DN) is considered the primary causes of end-stage renal disease (ESRD) and related to abnormal glycolipid metabolism, hemodynamic abnormalities, oxidative stress chronic inflammation. Antagonism vascular endothelial growth factor B (VEGF-B) could efficiently ameliorate DN by reducing lipotoxicity. However, this pharmacological strategy far from satisfactory, as it ignores numerous pathogenic factors, including anomalous reactive oxygen species (ROS) generation...
The pathogenesis of diabetic kidney disease (DKD) is complicated. Current clinical treatments fail to achieve satisfactory efficacy in the prevention DKD progression, it urgently needs novel and effective treatment for DKD. In this study, we firstly demonstrated that renal lipid metabolism abnormality inflammation significantly changed conditions by mining public transcriptomic data patient samples. KEGG analysis further exhibited critical role vascular endothelial growth factor B (VEGF-B)...
Kidney damage initiates the deteriorating metabolic states in tubule cells that lead to development of end-stage renal disease (ESTD). Interleukin-22 (IL-22) is an effective therapeutic antidote for kidney injury via promoting recovery, but little known about underlying molecular mechanisms. Here, we first provide evidence IL-22 attenuates reprogramming tubular epithelial (TECs). Specifically, our data suggest regulates mitochondrial function and glycolysis damaged TECs. Further observations...
This study was performed to explore other potential mechanisms underlying hemolysis in addition pore-formation of tentacle extract (TE) from the jellyfish Cyanea capillata. A dose-dependent increase observed rat erythrocyte suspensions and hemolytic activity TE enhanced presence Ca2+, which attenuated by Ca2+ channel blockers (Diltiazem, Verapamil Nifedipine). Direct intracellular after treatment confocal laser scanning microscopy, could be depressed Diltiazem. The osmotic protectant...
Aristolochic acid nephropathy (AAN), as a rapidly progressive interstitial due to excessive ingestion of aristolochia herbal medications, has recently raised considerable concerns among clinicians and researchers its underlying pathogenic mechanisms are largely unclear. In the current study, we identified NLRP3 inflammasome activation novel pathological mechanism AAN. We found that was aberrantly activated both in vivo vitro after AA exposure. Blockade IL-1β by IL-1Ra significantly...
Background/Aims: Overproliferation of mesangial cells was believed to play an important role in the progress diabetic nephropathy, one primary complications diabetes. Hydrogen sulfide (H2S), a well-known and pungent gas with distinctive smell rotten eggs, discovered protective nephropathy. Methods: MTT assay used examine viability cells. Small interfering RNA knock down expression TLR4 while specific inhibitor LY294002 suppress function PI3K. H2S generation rate determined by...
Recombinant human arginase (rhArg) is an arginine-degrading enzyme that has been evaluated as effective therapeutics for varieties of malignant tumors and in clinical trials hepatocellular carcinoma (HCC) treatment nowadays. Our previous studies have reported rhArg could induce autophagy apoptosis lymphoma cells inhibiting enhance the efficacy on lymphoma. However, whether what roles plays leukemia are unclear. In this study, we demonstrated lead to formation autophagosomes upregulation...
B-cell non-Hodgkin's lymphoma (B-NHL) is one of the most common types cancer in world, with half patients dying due to resistance or tolerance against treatment. Thus, a novel therapeutic approach for B-NHL treatment was urgently needed. In this study, we investigated potential co-inhibition Hedgehog signaling pathway (Hh) and autophagy therapy. We reported that vismodegib, an inhibitor pathway, could block Hh induce cytotoxicity apoptosis Raji cells. During process, activated as response...
Background and aim Protein-energy wasting (PEW) is critically associated with the reduced quality of life poor prognosis hemodialysis patients. However, diagnosis criteria PEW are complex, characterized by difficulty in estimating dietary intake assessing muscle mass loss objectively. We performed a cross-sectional study patients to propose novel prediction model. Materials methods A total 380 who underwent maintenance were enrolled this study. The data analyzed univariate multivariable...
Influenza A virus infection is usually associated with acute lung injury, which typically characterized by tracheal mucosal barrier damage and an interleukin 17A (IL-17A)-mediated inflammatory response in tissues. Although targeting IL-17A has been proven to be beneficial for attenuating inflammation around cells, it still a limited effect on pulmonary tissue recovery after influenza infection. In this research, 22 (IL-22), cytokine involved the repair of barrier, was fused C-terminus...
Abstract Kidney damage initiates the deteriorating metabolic states in tubule cells that lead to development of end-stage renal disease (ESTD). Interleukin 22 (IL-22) is an effective therapeutic antidote for kidney injury via promoting recovery, but little known about underlying molecular mechanisms. Here we first provide evidence IL-22 attenuates reprogramming tubular epithelial (TECs). Specifically, our data suggest regulates mitochondrial function and glycolysis damaged TECs. Further...