A5100672229- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Vitamin C and Antioxidants Research
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Multiple and Secondary Primary Cancers
- Supercapacitor Materials and Fabrication
- Bladder and Urothelial Cancer Treatments
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Lesions and Carcinomas
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
- Gastrointestinal Tumor Research and Treatment
Renji Hospital
2018-2025
Shanghai Jiao Tong University
2016-2025
Nanjing University of Chinese Medicine
2014-2025
Jiangsu Province Hospital
2020-2025
Chinese PLA General Hospital
2025
Henan University
2024
Fudan University Shanghai Cancer Center
2011-2023
Third Xiangya Hospital
2021-2023
Central South University
2021-2023
Shanghai Medical College of Fudan University
2011-2023
Abstract Background Increased liver stiffness exerts a detrimental role in driving hepatocellular carcinoma (HCC) malignancy and progression, indicates high risk of unfavorable outcomes. However, it remains largely unknown how matrix as an independent cue triggers epithelial-mesenchymal transition (EMT) facilitates HCC metastasis. Methods Buffalo rat models with different backgrounds vitro Col I-coated cell culture system tunable were used the study to explore effects on EMT occurrence its...
Recent evidence shows that inducing ferroptosis may improve efficacy of tumor therapy. However, ferroptosis-related genes have been little studied in patients with breast cancer especially the neoadjuvant setting. ACSL4 and GPX4 well established as positive negative regulator ferroptosis, respectively. This study aimed to explore predictive value for administered chemotherapy.This included treated paclitaxel-cisplatin-based chemotherapy. Immunohistochemistry staining was carried out on core...
The purpose of this study is to examine the association between a novel adiposity parameter, weight-adjusted-waist index (WWI), and erectile dysfunction (ED).According National Health Nutrition Examination Survey (NHANES) 2001-2004, total 3884 participants were categorized as ED non-ED individuals. WWI was calculated waist circumference (WC, cm) divided by square root weight (kg). Weighted univariable multivariable logistic regression models conducted assess correlation ED. Smooth curve...
Gastric adenocarcinoma (GAC), particularly the Lauren intestinal-type GAC (IGAC), leads to significant mortality in China due limited effectiveness of current treatments. This study aims investigate mechanisms immune suppression IGAC identify potential targets for enhancing immunotherapy outcomes. Performing an extensive collection and re-analysis single-cell RNA sequencing (scRNA-seq) tumor tissues corresponding noncancerous mucosae from 15 Chinese patients diagnosed with IGAC, we...
Viperin is a type-I and -II interferon-inducible intracytoplasmic protein that mediates antiviral activity against several viruses. A previous study has reported viperin could limit hepatitis C virus (HCV) replication in vitro . However, the underlying mechanism remains elusive. In present study, we found overexpression of inhibit HCV dose-dependent manner both replicon HCVcc systems. Furthermore, through co-immunoprecipitation laser confocal microscopic analysis, was to interact with host...
Strategies to prevent diabetic microvascular angiopathy focus on the vascular endothelium. Because red blood cells (RBCs) are less deformable in diabetes, we explored an original concept linking decreased RBC deformability ascorbate and hyperglycemia. We characterized concentrations from human mouse RBCs plasma, showed inverse relationship between deformability, measured by osmotic fragility. deficient mice were osmotically sensitive, appeared as spherocytes, had β-spectrin. These...
Abstract Background The pretherapeutic serum interleukin-8 (sIL-8) levels have been revealed to be increased in about half of patients with locally advanced gastric cancer. However, the roles IL-8 lymph node metastasis (LNM) and underlying mechanisms remain unclear. Methods 146 primary carcinoma were enrolled this study. ELISA was used measure levels. CD4/CD8 ratio programmed cell death-1 (PD-1) expression T cells tumor tissues, tumor-draining nodes (TDLNs) non-draining (NDLNs) assayed flow...
Abstract Purpose: Despite accumulating evidence on dual blockade of HER2 for locally advanced HER2-positive breast cancer, no robust supports the addition pyrotinib to trastuzumab in neoadjuvant setting. The NeoATP trial aimed evaluate efficacy and safety with chemotherapy. Patients Methods: phase II included female patients histologically confirmed stage IIA IIIC primary invasive cancer. Eligible received weekly paclitaxel–cisplatin chemotherapy four cycles. endpoint was pathologic complete...
Efficient dispersion and electrophoretic deposition (EPD) of multiwalled carbon nanotubes (MWCNTs) was achieved using organic dyes, such as pyrocatechol violet (PV) m-cresol purple (CP). The problem MnO2 nanoparticle in concentrated suspensions addressed by the use PV a dispersant. analysis comparison experimental data for CP provided insight into influence chemical structures dyes on their adsorption MWCNTs MnO2. attributed to π–π interactions catecholate type bonding, respectively. EPD...
The consensus of endoscopic therapy for early gastric cancer (EGC) mainly depends on its clinicopathological features. However, the roles tumor-associated neutrophils (TANs) in EGC remain uncertain. Here, we explored predictive role lymph node metastasis (LNM) EGC. Three hundred twenty-two patients who underwent radical gastrectomy were enrolled. Preoperative peripheral blood was used to analyze neutrophil-to-lymphocyte ratio (NLR), and different status TANs determined by hematoxylin & eosin...
Cuproptosis is a new form of copper-dependent programmed cell death commonly occurring within the body. There emerging evidence indicating that cuproptosis has significant regulatory function in onset and progression cancer. However, it still unclear how regulates cancer whether other genes are involved regulation. Using TCGA-COAD dataset 512 samples, we found seven ten markers showed prognostic value colorectal (CRC) using Kaplan–Meier survival analysis. Furthermore, 31 cuproptosis-related...
Abstract Background Upregulation of the PD-L1 (CD274) immune checkpoint ligand on tumor surface facilitates escape and limits application immunotherapy in various cancers, including breast cancer. However, mechanisms underlying high levels cancers are still poorly understood. Methods Bioinformatics analyses vivo vitro experiments were carried out to assess association between CD8 + T lymphocytes TIMELESS (TIM) expression, discover TIM, transcription factor c-Myc, cancer cell lines. Results...
Interleukin (IL)-8 plays the critical role in initiation of micro-environmental inflammation responsible for tumour growth and patient prognosis. This study aimed at investigating molecular mechanisms IL-8 production from human hepatocellular carcinoma (HCC) cells. The levels phosphorylation p38 mitogen-activated protein kinase (MAPK), ERK1/2 Akt MHCC-97H cells were measured by ELISA, Western blot immunofluorescence. NF-κB p65 nuclear translocation was determined non-radioactive p50/p65...
Abstract Success in curing breast cancer largely depends on the stage at diagnosis. Circulating microRNAs are becoming a promising noninvasive biomarker. We postulate that postoperative decline circulating might have diagnostic and prognostic value. Applying high-throughput microarrays, we screened dysregulated paired serum samples before after surgery. The relative concentrations of putative markers between early cancer-free groups were evaluated training set verified validation set....
The accurate positioning of sentinel lymph node (SLN) by tracers during surgery is an important prerequisite for SLN biopsy. A major problem traditional in biopsy the short window due to fast diffusion through lymphatics, resulting a misjudgment between and second echelon (2nd LN). Here, nontoxic Raman nanoparticle tracer, termed gap-enhanced tags (GERTs), intraoperative SLNs with sufficient surgical time designed. In white New Zealand rabbit models, GERTs enable precise identification...
Abstract Dendrobium nobile Lindl polysaccharides (DNLP) exhibited various biological functions. This study aimed to investigate the protective effects of DNLP on testicular spermatogenic function in streptozotocin (STZ)‐induced diabetic rats comparison with metformin. The blood glucose level was significantly increased and homeostatic model assessment for insulin resistance (HOMA‐IR) aggravated markedly rats. weight testis epididymis, sperm number motility were decreased pathologic changes...
The use of dual-tracer contrast agents in clinical applications, such as sentinel lymph node (SLN) identification, offers significant advantages including enhanced accuracy, sensitivity, well comprehensive and multimodal visualization. In the current practice, SLNs are typically marked prior to surgical resection by multiple sequential injections two tracers, radioactive tracer methylene blue (MB) dye. This imposes physical psychological burden on patients medical staff. Surface-enhanced...