A5050965074- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Respiratory Support and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Mycobacterium research and diagnosis
- Cancer, Lipids, and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Chromatin Remodeling and Cancer
- Cystic Fibrosis Research Advances
- Photodynamic Therapy Research Studies
- Protein Degradation and Inhibitors
- Asthma and respiratory diseases
- Intestinal and Peritoneal Adhesions
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- 3D Surveying and Cultural Heritage
Central South University
2016-2025
Third Xiangya Hospital
2015-2025
Chang Gung Memorial Hospital
2013-2025
Nanchong Central Hospital
2021-2025
FEV (Germany)
2022-2025
Capital Medical University
2025
Beijing Anzhen Hospital
2025
Chang Gung University
2013-2023
North Sichuan Medical University
2021-2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2023
YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1) is a core factor in methylation modification. Recent studies have shown that m6A closely related to multiple tumors, thus YTHDF1 may also play role tumorigenesis. This study, aimed explore the of colorectal cancer (CRC). In this we identified as being highly expressed at mRNA and levels TCGA, GEO CRC primary CRC. Furthermore, gene copy number was positively correlated with expression Knocking down significantly inhibited cell's...
Background Ferroptosis is a newly defined form of programmed cell death that plays an important role in many cancers. However, ferroptosis-related lncRNAs (FRLs) involved the regulation colon cancer are not thoroughly understood. This study aimed to identify prognostic FRL signature and explore its potential molecular function. Methods RNA-seq data relevant clinical information were obtained from The Cancer Genome Atlas (TCGA) database, list genes was extracted FerrDb website. Analysis...
Objective: Early reports have indicated that the Omicron variant of coronavirus disease 2019 (COVID-19) may be associated with low mortality. However, mortality rate critical patients in Taiwan COVID-19 caused by different variants has not been well described. Methods: This retrospective cohort study was conducted at Linkou Branch Chang Gung Memorial Hospital, Taiwan, from April 2020 to September 2022. Critically ill who had confirmed SARS-CoV-2 infection and were on mechanical ventilation...
Abstract Objectives Chemoresistance development represents a major obstacle to the successful treatment of colorectal cancer ( CRC ). The aim this study was elucidate mechanism by which miR‐506 reverses oxaliplatin chemoresistance in . Methods In study, levels were measured 74 patients with colon via quantitative real‐time polymerase chain reaction qRT ‐ PCR ) and situ hybridization ISH We subsequently analysed relationship between expression patient survival Kaplan‐Meier method. MTT assay...
Circular RNAs (circRNAs) play important roles in cancer progression and metabolism regulation. Serine/glycine supports the growth of cells by contributing to their anabolic demands epigenome as well regulating redox state. However, role circRNA regulation serine/glycine has not been elucidated.Microarray analysis was used screen differentially expressed novel circRNAs. qRT-PCR FISH were utilized analyzed expression circMYH9. CCK8, colony formation FACS analyze proliferation colorectal (CRC)...
Previous studies have shown that the N6-methyladenosine (m6A) modification enhances binding ability of mRNAs/long noncoding RNAs (lncRNAs) to microRNAs (miRNAs), but impact this on competitive endogenous RNA (ceRNA) function circular (circRNAs) is unclear.We used a human circRNA microarray detect expression profiles circRNAs in 3 pairs cancer and paracancerous tissues from patients with colorectal (CRC) peripheral blood specimens CRC healthy individuals. The highly expressed both tumour CRC,...
Abstract Cisplatin (DDP) resistance is an important factor that decreases the effect of chemotherapy, thus leading to local recurrence and lymph node metastasis hypopharyngeal squamous cell carcinoma (HSCC). We aimed explore role mechanism extrachromosomal circular DNA (eccDNA) in DDP HSCC. In our research, HSCC line FaDu DDP-resistant FaDu/DDP were used as subjects. eccDNA sequencing whole transcriptome conducted, followed by a combined analysis two profiles. Outward PCR, inward PCR Sanger...
Multimodal imaging-guided combinational phototherapies triggered by a single near-infrared (NIR) laser are highly desirable. However, their development is still big challenge. Herein, we have developed an "acceptor-donor-acceptor'-donor-acceptor" structured organic phototheranostics (Y16-Pr) with strong light-harvesting ability in the NIR region. After being modified polyethylene glycol (PEG), obtained biocompatible nanoparticles (Y16-Pr-PEG NPs) could conduct NIR-II fluorescence imaging...
Circular RNAs (circRNAs) are covalently closed RNA structures that play multiple roles in tumorigenesis and progression. Compared with exon‒intron circRNAs, the biological functions implications of intergenic circRNAs human cancer still poorly understood. Here, we performed circRNA microarray analysis identified an circRNA,
Metastasis is the major cause of colorectal cancer (CRC) mortality. Emerging evidence suggests that long noncoding RNAs (lncRNAs) drive metastasis and their regulatory pathways could be targeted for preventing metastasis. However, underlying mechanisms lncRNAs in CRC remain poorly understood. Microarray analysis was used to screen differentially expressed lncRNAs. Transwell assays, fibronectin cell adhesion mouse models were utilized evaluate metastatic capacities vitro vivo. Chromatin...
Emerging evidence has identified the vital role of long noncoding RNAs (lncRNAs) in development colorectal cancer. In this study, we aimed to investigate lncRNA gastric carcinoma highly expressed transcript 1 (GHET1) We analyzed expression GHET1 cancer (CRC) tissues by using ISH. found that was significantly increased CRC samples compared with adjacent tissues. Furthermore, had higher mRNA levels than their matched also cell lines human normal colon epithelial cells. Downregulation mediated...
Long noncoding RNAs (lncRNAs) have been indicated as important regulators in various human cancers. However, the overall biological roles and clinical significance of most lncRNAs colon carcinogenesis are not fully understood. Hence, we investigated significance, function mechanism LINC01234 cancer. First, analyzed alterations cancer tissues corresponding paracancerous through analysis sequencing data obtained from The Cancer Genome Atlas patients. Next, evaluated effect on cell...
// Yi Zhang 1, 2, * , Changwei Lin 3, Guoqing Liao 1 Sheng Liu Jie Ding 4 Fang Tang 5 Zhenran Wang Xingsi Liang Bo Li Yangchao Wei Qi Huang Xuan Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, 410008, PR China 2 Oncological Affiliated Hospital Xuzhou Medical College, 221000, 3 Third Guizhou Provincial People's 550000, Hepatobiliary Guilin 541000, These authors have contributed equally to this work Correspondence to: Liao, e-mail: liaoguoqing@medmail.com.cn...
Abstract Background Bronchiectasis is a chronic infectious respiratory disease with diverse causes and ethnic or geographic differences. However, few large-scale studies of its etiology have been conducted in Asia. This study aimed to determine the clinical features bronchiectasis Taiwan. Methods longitudinal cohort investigated newly diagnosed non-cystic fibrosis patients from January 2002 December 2016. The clinical, functional microbiological data were retrieved Chang Gung Research...
The biological functions of long non‑coding RNAs (lncRNAs) in cancer have not been fully elucidated. present study demonstrated that the expression a newly identified lncRNA, RP1‑85F18.6, was upregulated colorectal (CRC) tissues and cell lines. Knockdown lncRNA RP1‑85F18.6 served key role tumor inhibition, reduced proliferation invasion, disrupted cycle, increased apoptosis pyroptosis CRC cells. Conversely, overexpression exerted opposite effects. Furthermore, silencing decreased ΔNp63 at...
The long noncoding RNA (lncRNA) LUCAT1 was recently reported to be upregulated and play an essential role in multiple cancer types, especially colorectal (CRC), but the molecular mechanisms of CRC are mostly unreported. Here, a systematic analysis LUACT1 expression is performed with data from TCGA database clinic samples. identified as putative oncogene, which significantly associated poor prognosis. Loss restricts proliferative capacities vitro vivo. Mechanically, NCL protein binding...
Abstract Mechanical ventilation ( MV ) used in patients with acute respiratory distress syndrome ARDS can increase lung inflammation and pulmonary fibrogenesis. Src is crucial mediating the transforming growth factor TGF )‐β1‐induced epithelial–mesenchymal transition EMT during fibroproliferative phase of . Nintedanib, a multitargeted tyrosine kinase inhibitor that directly blocks Src, has been approved for treatment idiopathic fibrosis. The mechanisms regulating interactions among , remain...
Abstract Transposable elements (TEs) through evolutionary exaptation have become an integral part of the human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While functional impacts TE-derived on early embryogenesis been recognized, their roles in malignancy are only starting to emerge. Here we show that many TEs, especially pluripotency-related endogenous retrovirus H (HERVH), abnormally activated colorectal cancer (CRC) samples. Transcriptional...
We aim to report the incidence, mortality and disability-adjusted life years (DALYs) between 1990 2019 provide predictions 2035.We use estimates from Global Burden of Disease, Injuries Risk Factors Study analyse DALYs.In 2019, there were more than 209,149 incidence cases, with age-standardised rates (ASRs) 2.5. Laryngeal cancer accounted for 123,356 death ASRs 1.5. was also responsible 3.26 million (3,034,634 3,511,354) DALYs, 38.8 (36.1 41.8). In Central Europe had highest rate. At national...
Patients with metabolic syndrome (MetS) undergoing surgery are at high risk of developing peritoneal adhesions and other severe postoperative complications. However, the single shielding function absence physiological activity render conventional methods less useful in preventing patients MetS. To address this challenge, a convenient method is introduced for novel tissue-adhesive hydrogel called oxidized dextran-metformin (ODE-ME) via Schiff base linkages. This injectable ODE-ME exhibits...