A5063169546- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Electrochemical sensors and biosensors
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Analytical Chemistry and Sensors
- Toxic Organic Pollutants Impact
- Advanced Chemical Sensor Technologies
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Nanoparticle-Based Drug Delivery
- Effects and risks of endocrine disrupting chemicals
- Nitric Oxide and Endothelin Effects
- Ferroptosis and cancer prognosis
- Eicosanoids and Hypertension Pharmacology
- Odor and Emission Control Technologies
- Porphyrin and Phthalocyanine Chemistry
- Lung Cancer Research Studies
Nanjing Forestry University
2021-2025
University of Massachusetts Amherst
2020-2025
First Affiliated Hospital of Zhengzhou University
2015-2025
Sun Yat-sen University
2025
State Key Laboratory of Pollution Control and Resource Reuse
2021-2024
Nanjing University of Science and Technology
2021-2024
Xuzhou Medical College
2017-2024
Guangdong Pharmaceutical University
2023
Integrated Chinese Medicine (China)
2023
Ministry of Education of the People's Republic of China
2023
Abstract The prostate gland mainly contains basal and luminal cells constructed as a pseudostratified epithelium. Annotation of epithelial transcriptomes provides foundation for discoveries that can impact disease understanding treatment. Here we describe genome-wide transcriptome analysis human benign prostatic populations using deep RNA sequencing. Through molecular biological characterizations, show the differential gene-expression profiles account their distinct functional properties....
Acetaminophen (APAP)-induced liver injury (AILI) has become a growing public health problem. Ferroptosis, an iron-dependent form of cell death associated with lipid peroxide accumulation, been recently implicated in AILI. The activation the Nrf2 signaling pathway is potential therapy for Kaempferol (KA), flavonoid widely existing edible plants, reported to exert profound anti-inflammatory and antioxidant activities. This study aimed investigate whether KA exerts anti-AILI effects via...
Circular RNAs (circRNAs) play important roles in cancer progression and metabolism regulation. Serine/glycine supports the growth of cells by contributing to their anabolic demands epigenome as well regulating redox state. However, role circRNA regulation serine/glycine has not been elucidated.Microarray analysis was used screen differentially expressed novel circRNAs. qRT-PCR FISH were utilized analyzed expression circMYH9. CCK8, colony formation FACS analyze proliferation colorectal (CRC)...
Abstract Background Circular RNAs (circRNAs) play important roles in the occurrence and development of cancer chemoresistance. DNA damage repair contributes to proliferation cells resistance chemotherapy-induced apoptosis. However, role circRNAs regulation needs clarification. Methods RNA sequencing analysis was applied identify differentially expressed circRNAs. qRT-PCR conducted confirm expression hsa_circ_0007919, CCK-8, FCM, single-cell gel electrophoresis IF assays were used analyze...
Hydrogen sulfide (H2S) is closely related to physiological diseases, environmental pollution, food safety, and plant growth. Herein, a new nopinone-based near-infrared fluorescent probe has been developed detect H2S with superior performance, including large Stokes shift, low detection limit, good selectivity, fast response time. NPD-H2S was used in water wine samples quantitatively. In addition, could be fabricate nanofiber membranes as portable tool for sensitively detecting vapor using...
Intracellular delivery of functional proteins is a promising, but challenging, strategy for many therapeutic applications. Here, we report new methodology that overcomes drawbacks traditional mesoporous silica (MSi) particles protein delivery. We hypothesize engineering enhancement in interactions between and vehicles can facilitate efficient encapsulation intracellular In this strategy, surface lysines were modified with self-immolative linker containing terminal boronic acid...
Hydrogen sulfide (H2S) is closely related to food safety, environmental pollution, and human health. Herein, a fluorescent turn-on responsive probe, 3-(2,4-dinitrophenoxy)-7-(4-(diphenylamino)phenyl)-2-(furan-2-yl)-4H-chromen-4-one (DPF-NP), with large Stokes shift (210 nm) based on the natural product flavonol was synthesized for detecting H2S. DPF-NP showed high selectivity sensitivity, low limit of detection (96 nM), fast response (3 min) After reacting H2S, exhibited strong orange...
Hydrogen peroxide (H2O2) is involved in many important tasks normal cell metabolism and signaling. However, abnormal levels of H2O2 are associated with the occurrence several diseases. Therefore, it to develop a new method for detection H2O2in vivo vitro. A turn-off sensor, 2,2-difluoro-4,6-bis(3-methoxy-4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)styryl)-2H-1,3,2-dioxaborine (DFCB), based on curcumin was developed H2O2. The DFCB, an orange-emitting constructed by employing...
Hydrogen sulfide (H2S) has comprehensive contributions to maintaining the normal operation and stability of organisms, it also occurs in wastewater environment is related deterioration foodstuffs. Therefore, developing high-sensitive detection techniques for tracing H2S promising meaningful. Inspired by this, a novel nopinone-based fluorescent probe NPS recognition was designed synthesized with excellent sensitivity, low limit (79 nM), good selectivity, wide pH range (5-9). could emit strong...