A5041942612- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Acoustic Wave Phenomena Research
- Circular RNAs in diseases
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Underwater Vehicles and Communication Systems
- Cancer Genomics and Diagnostics
- Underwater Acoustics Research
- RNA Interference and Gene Delivery
- Appendicitis Diagnosis and Management
- Glycosylation and Glycoproteins Research
- Head and Neck Surgical Oncology
- Teratomas and Epidermoid Cysts
- Neuroendocrine Tumor Research Advances
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Ultrasonics and Acoustic Wave Propagation
- Mechanisms of cancer metastasis
- Diverticular Disease and Complications
- Colorectal Cancer Screening and Detection
- Genetic and Kidney Cyst Diseases
Wuhan University
2019-2025
Zhongnan Hospital of Wuhan University
2019-2025
Health Commission of Anhui Province
2024-2025
Northwestern Polytechnical University
2009-2023
Third Xiangya Hospital
2017-2019
Central South University
2017-2019
First Affiliated Hospital of Nanchang University
2014-2018
Nanchang University
2014-2018
College of Marin
2012
YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1) is a core factor in methylation modification. Recent studies have shown that m6A closely related to multiple tumors, thus YTHDF1 may also play role tumorigenesis. This study, aimed explore the of colorectal cancer (CRC). In this we identified as being highly expressed at mRNA and levels TCGA, GEO CRC primary CRC. Furthermore, gene copy number was positively correlated with expression Knocking down significantly inhibited cell's...
Peritoneal metastasis is the most frequent cause of death in patients with advanced gastric carcinoma (GC). The phosphatase regenerating liver-3 (PRL-3) recognized as an oncogene and plays important role GC peritoneal metastasis. However, mechanism how PRL-3 regulates invasion unknown. In present study, we found that presented high expression metastasis, but tensin homologue (PTEN) was weakly expressed. p-PTEN/PTEN ratio also higher than normal tissues. We same phenomenon when comparing...
Abstract Copy number variations (CNVs) are key drivers of colorectal cancer (CRC). Our previous studies revealed that protein O-fucosyltransferase 1 ( POFUT1 ) overexpression is driven by CNVs during CRC development. The potential role and underlying mechanisms in were not investigated. In this study, we analyzed the expression from cosmic TCGA databases confirmed highly expressed CRC. We used well characterized cell lines, including SW620 HCT116 to establish a model knockdown line. Using...
Researchers hold the view that PLAGL2 is overexpressed in many malignancies and it can promote tumor proliferation, migration, invasion self‑renewal; however, there no evidence revealing a relationship between colorectal cancer (CRC). In present study, genes are CRC were screened using COSMIC database GEPIA expression of carcinoma tissues pericarcinomatous was detected by RT‑qPCR western blot assays. A Cell Counting Kit‑8 assay, cell cycle analysis experiment xenograft model used to explore...
Research on DNA methylation offers great potential for the identification of biomarkers that can be applied accurately assessing an individual's risk cancer. In this article, we try to find ideal epigenetic genes involved in colorectal cancer (CRC) based a CRC database and our cohort. The top 20 with extremely high frequency hypermethylation were identified latest database. Remarkably, 3 HOXA included list ranked at top. percentage HOXA5, HOXA2, HOXA6 up 67.62, 58.36, 31.32%, respectively,...
Our previous study revealed that PLAGL2 or POFUT1 can promote tumorigenesis and maintain significant positive correlations in colorectal cancer (CRC). However, the mechanism leading to co-expression underlying functional biological implications remain unclear.Clinical tumor tissues TCGA dataset were utilized analyze of POFUT1. Luciferase reporter assays, specially made bidirectional promoter vectors ectopic expression 3'UTR employed mechanisms co-expression. In vitro vivo assays performed...
Accumulating studies have demonstrated microRNAs (miRNAs/miRs) an important role in multiple processes of human malignant tumor development and progression. Decreased expression miR-125a-5p has been observed several types cancer, including gastric cancer (GC). However, the mechanism exact function GC not largely elucidated. In present study, reverse transcription-quantitative polymerase chain reaction indicated that was downregulated tissues cell lines compared with matched normal (P<0.01)...
Melanoma is a malignant tumor that seriously affects patients. The pathogenesis of melanoma complex, and the cell cycle closely related to progression. Based on catalog cancer somatic mutations, we found overexpression E2F3 gene ranked first in percentage increase not only but also all human tissues. However, there are few studies high expression its carcinogenic mechanism melanoma.We showed extensive copy number amplification was positively correlated with level. Patients had significantly...
// Miao Chen 1 , Daojiang Li Ni Gong Hao Wu Su Canbin Xie Hong Xiang 2 Changwei Lin and Xiaorong Department of Gastrointestinal Surgery, The Third Xiangya Hospital Central South University, Changsha, Hunan 410013, P. R. China Laboratory Medical Center, Correspondence to: Li, email: lixiaorong@medmail.com.cn Lin, linchangwei1987@csu.edu.cn Keywords: colorectal cancer, miR-133b, ABCC1, multidrug resistance, chemosensitivity Received: December 28, 2016 Accepted: March 03, 2017 Published: May...
Introduction Copy number variation is a significant characteristic of colorectal cancer progression. RBFOX1 (A2BP1) the gene with highest frequency copy loss in cancer, but current research related to it and relatively scarce. Methods Data from TCGA other sources were used analyze mRNA expression levels RBFOX1, as well their correlation clinical pathological data. Immunohistochemistry immunofluorescence experiments protein cells tissues. Results has high (22.4%) diverse variations High-level...
Growing evidence suggests that long non-coding RNAs (lncRNAs) play a key role in tumorigenesis. However, the mechanism remains largely unknown.Thousands of significantly dysregulated lncRNAs and mRNAs were identified by microarray. Furthermore, miR-133b-meditated lncRNA-mRNA ceRNA network was revealed, subset which validated 14 paired CRC patient tumor/non-tumor samples. Gene set enrichment analysis (GSEA) results demonstrated ENST00000520055 ENST00000535511 shared KEGG pathways with...
Pleomorphic adenoma gene like-2 (PLAGL2) is a zinc finger protein transcription factor, which upregulated and serves an oncogenic function in multiple human malignancies, including colorectal cancer (CRC). First, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression levels of PLAGL2 CRC tissues normal tissues. Then, bioinformatics analysis, RT-qPCR, western blotting, luciferase reporter assays RNA-binding immunoprecipitation were performed...
// Lu Xia 1, * , Daojiang Li 2, Changwei Lin 3 Shuchun Ou 1 Xiaorong and Songqing Pan Department of Neurology, Renmin Hospital Wuhan University, 430060, Hubei Provinces, China 2 General Surgery, The Third XiangYa Central South Changsha, Hunan 410013, Center for Experimental Medicine, Shared first authors Correspondence to: Pan, email: psq@medmail.com.cn Li, lixiaorong@medmail.com.cn Keywords: miR-132, miR-212, epilepsy, cancer, tumor-induced epileptogenesis Received: December 20, 2016...
Introduction: This retrospective study aims to compare open colectomy and hand-assisted laparoscopic surgery (HALS) in the management of acute obstructive right-sided colon cancer analyze evaluate feasibility safety HALS. Patients Methods: Ten consecutive patients who underwent right hemicolectomy due were retrospectively well matched with 25 scheduled for a conventional laparotomy during same time. Demographic, intraoperative, postoperative data assessed. Results: The HALS group had...
Cancer stem cells (CSCs) are responsible for all important characteristics of tumors. DEAD-box helicase 27 (DDX27) is a member the RNA family, and there have been only few studies on DDX27 function in cancer cells. This study aimed at exploring whether has any relation to tumorigenesis colorectal (CRC) elucidating potential mechanism.Data from Catalog Of Somatic Mutations In Cancer, Gene Expression Omnibus, The Genome Atlas databases reveal that overexpressed CRC tissues. qRT-PCR Western...
// Daojiang Li 1 , Changwei Lin Miao Chen Nanpeng Yuheng Du Su Chunxing Yang Ni Gong Hao Wu Runliu Arad Jain 3 Yi Zhang 1, 2 and Xiaorong Department of General Surgery, The Third Xiangya Hospital Central South University, Changsha, Hunan 410013, China Center for Experimental Medicine, College Arts Science, University Virginia, Charlottesville, Virginia 22904, United States America Correspondence to: Li, email: lixiaorong@medmail.com.cn Zhang, yzhangxy3@126.com Keywords: 20q, CNA,...