A5101769225- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- interferon and immune responses
- RNA regulation and disease
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- Colorectal Cancer Treatments and Studies
- Immune Response and Inflammation
- Circular RNAs in diseases
- Gene Regulatory Network Analysis
- Inflammatory Bowel Disease
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- Gene expression and cancer classification
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Viral Infections and Vectors
- Single-cell and spatial transcriptomics
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
Zhongnan Hospital of Wuhan University
2019-2025
Wuhan University
2019-2025
Hubei Provincial Center for Disease Control and Prevention
2020-2025
Zhejiang University
2025
Lanzhou Jiaotong University
2024
Fudan University
2021-2022
Pudong Medical Center
2022
Analysis and Testing Centre
2021
Nanchang University
2015-2017
Pingxiang University
2016-2017
The heuristic k-means algorithm, widely used for cluster analysis, does not guarantee optimality.We developed a dynamic programming algorithm optimal one-dimensional clustering.The is implemented as an R package called Ckmeans.1d.dp.We demonstrate its advantage in optimality and runtime over the standard iterative algorithm.
It remains unclear whether causal, rather than merely correlational, relationships in molecular networks can be inferred complex biological settings. Here we describe the HPN-DREAM network inference challenge, which focused on learning causal influences signaling networks. We used phosphoprotein data from cancer cell lines as well silico a nonlinear dynamical model. Using data, scored more 2,000 submitted by challenge participants. The spanned 32 contexts and were terms of validity with...
Abstract M icroRNAs (miRNAs) are important regulators in gene expression. The dysregulation of miRNA expression is widely reported the transformation from physiological to pathological states cells. A large number differentially expressed miRNAs (DEMs) have been identified various human cancers by using high-throughput technologies, such as microarray and miRNA-seq. Through mining published studies with experiment information, database DEMs (dbDEMC) was constructed aim providing a systematic...
The systemic therapeutic utilisation of RNA interference (RNAi) is limited by the non-specific off-target effects, which can have severe adverse impacts in clinical applications. accurate use RNAi requires tumour-specific on-demand conditional activation to eliminate effects RNAi, for conventional systems cannot be used. Herein, a tumourous biomarker-activated platform achieved through careful design prodrugs extracellular vesicles (EVs) with cancer-specific recognition/activation features....
Long non-coding RNA (lncRNA) plays an important role in tumorigenesis. However, the expression pattern and function of lncRNAs laryngeal squamous cell carcinoma (LSCC) are still unclear. To investigate aberrantly expressed mRNAs advanced LSCC, we screened lncRNA mRNA profiles 9 pairs primary Stage IVA LSCC tissues adjacent non-neoplastic by integrated microarrays. Gene Ontology pathway analysis were performed to find out significant differentially mRNAs, gene-gene functional interaction...
Abstract As the largest transporter family impacting on tumor genesis and development, prognostic value of solute carrier (SLC) members has not been elucidated in colorectal cancer (CRC). We aimed to identify a signature from SLC comprehensively analyze their roles CRC. Firstly, we downloaded transcriptome data clinical information CRC samples GEO (GSE39582) TCGA as training testing dataset, respectively. extracted expression matrix genes established model by univariate multivariate Cox...
Inflammatory bowel disease (IBD) is a chronic idiopathic gastrointestinal disease. Increasing evidence suggests that microRNAs (miRNAs) may participate in the pathophysiology of IBD.A miRCURY™ LNA Array and situ hybridization were employed to screen for differentially expressed miRNAs (DEMs) fecal specimens from 41 IBD patients (22 ulcerative colitis (UC), 19 Crohn's (CD)) 23 healthy controls (HC). RT-qPCR was performed confirm findings. The DEMs target genes corresponding biological...
IFN regulatory factor (IRF)3 is a central regulator for IFN-β expression in different types of pathogenic infections. Mammals have various sensors that are involved monitoring pathogen intrusions. These can trigger IRF3-mediated antiviral responses through pathways. Endoplasmic reticulum-associated proteins stimulator gene (STING) and zinc finger DHHC-type containing 1 (ZDHHC1) critical mediators IRF3 activation response to viral DNA In this study, grass carp STING ZDHHC1 were found some...
The high heterogeneity of colorectal cancer (CRC) is the main clinical challenge for individualized therapies. Molecular classification will contribute to drug discovery and personalized management optimizing. Here, we aimed characterize molecular features CRC by a system based on metabolic gene expression profiles. 435 samples from Genomic Data Commons data portal were chosen as training set while 566 sample in GSE39582 selected testing set. Then, non-negative matrix factorization...
A 60-year-old male presented to the orthopedic department in October 2022 with a 20-day history of hoarseness. Two weeks before admission, nasopharyngolaryngoscopy had identified right vocal cord paralysis, and chest computed tomography (CT) revealed an upper mediastinal mass. Additionally, esophagogastroduodenoscopy performed 3 months earlier shown evidence chronic esophagitis. At presentation, enhanced CT confirmed mass measuring 21mm × 15 mm, located near superior thoracic aperture...
Peroxisomes are pivotal metabolic organelles that exist in almost all eukaryote cells. A reduction numbers and enzymatic activities of peroxisomes was found colon adenocarcinomas. However, the role or peroxisome pathway colorectal cancer (CRC) is not defined.In current study, a score calculated to indicate activity using gene set variant analysis based on transcriptomic datasets. CIBERSORTx chosen infer enriched immune cells for tumors among subgroups. The SubMap algorithm applied predict...
Tumor necrosis factor superfamily member 13 (TNFSF13) modulates cell proliferation and apoptosis participates in the pathogenesis of solid tumors, but its role laryngeal cancer development is not clearly defined. In order to investigate whether TNFSF13 can be used as a biomarker for diagnosis prognosis squamous carcinoma (LSCC) carcinogenesis, we conducted immunohistochemistry ELISA assays evaluate expression level patients contrast. We also experiments on functional study vitro. found that...
Abstract microRNAs (miRNAs) are important regulators in gene expression. The deregulation of miRNA expression is widely reported the transformation from physiological to pathological state cells. A large amount differentially expressed miRNAs (DEMs) have been identified various human cancers by using high-throughput technologies, such as microarray and miRNA-seq. Through mining published researches with experiment information, database (dbDEMC) was constructed aim providing a systematic...