A5110918889- Protein Degradation and Inhibitors
- Chromatin Remodeling and Cancer
- Dermatologic Treatments and Research
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Genomics and Chromatin Dynamics
- Pluripotent Stem Cells Research
- interferon and immune responses
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
Central South University
2021-2025
Xiangya Hospital Central South University
2024-2025
Abstract Transposable elements (TEs) through evolutionary exaptation have become an integral part of the human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While functional impacts TE-derived on early embryogenesis been recognized, their roles in malignancy are only starting to emerge. Here we show that many TEs, especially pluripotency-related endogenous retrovirus H (HERVH), abnormally activated colorectal cancer (CRC) samples. Transcriptional...
Mouse embryonic stem cells (mESCs) cycle in and out of a transient 2-cell (2C)-like totipotent state, driven by complex genetic circuit involves both the coding repetitive sections genome. While vast array regulators, including multi-functional protein Rif1, has been reported to influence switch fate potential, how they act concert achieve this cellular plasticity remains elusive. Here, modularizing known totipotency regulatory factors, we identify an unprecedented functional connection...
Abstract The healing of human skin wounds is susceptible to perturbation caused by excessive mechanical stretching, resulting in enlarged scars, hypertrophic or even keloids predisposed individuals. Keloids are fibro‐proliferative scar tissues that extend beyond the initial wound boundary, consisting actively progressing periphery and quiescent center. stretch‐associated outgrowth enhanced angiogenesis two features keloids. However, which cell population responsible for transducing...
Abstract The healing of human skin wounds is susceptible to perturbation caused by excessive mechanical stretching, resulting in enlarged scars, hypertrophic or even keloids predisposed individuals. Keloids are fibro-proliferative scar tissues that extend beyond the initial wound boundary, consisting actively progressing leading edge and quiescent center. stretch-associated outgrowth enhanced angiogenesis two features keloids. However, which cell population responsible for transducing...
Abstract The transposable elements (TEs) through evolutionary exaptation have become an integral part of human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While the functional impacts TE-derived on early embryogenesis are recognized, their role in malignancy has only started to emerge. Here we show that many TEs, especially pluripotency-related endogenous retrovirus H (HERVH), abnormally activated colorectal cancer (CRC) samples. transcriptional...
Abstract The transposable elements (TEs) through evolutionary exaptation have become an integral part of human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While the functional impacts TE-derived on early embryogenesis are recognized, their role in malignancy has only started to emerge. Here we show that many TEs, especially pluripotency-related endogenous retrovirus H (HERVH), abnormally activated colorectal cancer (CRC) samples. transcriptional...