A5079686991- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Gastrointestinal disorders and treatments
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- CO2 Reduction Techniques and Catalysts
- Pancreatitis Pathology and Treatment
- Dysphagia Assessment and Management
- Microtubule and mitosis dynamics
- Extracellular vesicles in disease
- Eosinophilic Esophagitis
Lanzhou University
2025
Lanzhou University Second Hospital
2025
Qiqihar Medical University
2024
Nanjing Drum Tower Hospital
2015-2024
Nanjing University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Hechi University
2024
Ningbo University
2024
Wannan Medical College
2024
China Electric Power Research Institute
2024
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease refractory to all targeted and immune therapies. However, our understanding of PDAC microenvironment especially the very limited partly due inaccessibility tumor tissues. Here, we present single-cell transcriptomic landscape synchronously resected primary tumors matched liver metastases. We perform comparative analysis on both cellular composition functional phenotype between tumors. Tumor cells exhibit distinct profile...
Chromatin accessibility is critical for tumor development, whose mechanisms remain unclear. As a crucial regulator chromatin remodeling, BRD4 promotes progression by regulating multiple genes. small-molecule inhibitor of BRD4, JQ1 has potent chemotherapeutic activity against various human cancers. However, whether potential anti-tumor effects and how regulates global transcription in gastric cancer (GC) largely unknown. In this research, we found was highly expressed GC tissues significantly...
Abstract Gastric cancer prognoses are persistently poor due to cancer's penchant metastasize. As a crucial regulator of signal transducer and activator transcription (STAT3) signaling, sirtuin 1's (SIRT1) function in gastric has not been well understood. Here, we report upregulated expression SIRT1 tissues isolated from patients. However, show that the depletion SIRT1‐mediated enhanced cell proliferation metastasis, resulted enrichment phosphorylated STAT3, acetylated matrix...
We aimed to develop and validate a real-time deep convolutional neural networks (DCNNs) system for detecting early gastric cancer (EGC).All 45,240 endoscopic images from 1364 patients were divided into training dataset (35823 1085 patients) validation (9417 279 patients). Another 1514 three other hospitals used as external validation. compared the diagnostic performance of DCNN with endoscopists, then evaluated endoscopists or without referring system. Thereafter, we ability in video...
Hypoxia is a characteristic of the tumor microenvironments within pancreatic cancer (PC), which has been linked to its malignancy. Recently, hypoxia reported regulate activity important carcinogenic pathways by changing status histone modification. NOX4, member NADPH oxidase (NOX), found be activated and promote progression in several cancers. But whether it involved epigenetic changes cells induced still unclear, biological roles PC also need explored.A hypoxic-related gene signature...
Abstract Circular RNAs (circRNAs) are involved in the regulation of gene expression different physiological and pathological processes. These macromolecules can act as microRNA (miRNA) sponges play an important role regulators throughout circRNA‐miRNA pathway. In this study, we established a radioresistance model with nasopharyngeal carcinoma cell line CNE‐2, then analyzed differences circRNAs between radioresistant normal lines using high‐throughput microarray. Tested included 1042...
Circular RNAs (circRNAs) are involved in cancer development via inhibition of miRNAs, which associated with differentiation, proliferation, migration, and carcinogenicity. Curcumin has antioxidant anti-cancer properties, it also been used as a radiosensitizer. In this study, we explored the potential relationships among curcumin, circRNAs, nasopharyngeal carcinoma (NPC). We compared differences circRNA levels NPC cell lines after radiotherapy treatment using high-throughput microarray....
Pancreatic cancer (PC) has a dismal prognosis due to its insidious early symptoms and poor detection rate. Exosomes can be released by various cell types tend potential novel biomarker for PC detection. In this study, we explored the proteomic profiles of plasma exosomes collected from patients with at different stages other pancreatic diseases.Plasma samples were six groups patients, including stage I/II, III/IV, well-differentiated neuroendocrine tumor (P-NET), cystic lesions (PCLs),...
Abstract BRD4 is a member of the BET protein family involved in chromatin remodeling and transcriptional regulation. Several inhibitors (BETi) have entered clinical trials, demonstrating potential inducing cancer cell apoptosis tumor regression. However, resistance to BETi common solid tumors. In pancreatic cancer, it found that cancer‐associated fibroblasts (CAFs) microenvironment reduce inhibitor JQ1 sensitivity by expression. Moreover, CAFs play crucial role formation dense stromal...
BackgroundColon adenocarcinoma (COAD) is a prevalent malignancy worldwide, yet, its underlying pathogenesis and genetic characteristics are still unclear. Previous studies have suggested that NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) may affect tumor progression across various cancers. However, this effect on COAD has rarely been reported. Thus, study investigated NDUFA4L2's prognostic diagnostic relevance explored potential connection with immune cell infiltration in...
Sepsis is a potentially fatal condition characterized by organ failure resulting from an abnormal host response to infection, often leading liver and kidney damage. Timely recognition intervention of these dysfunctions have the potential significantly reduce sepsis mortality rates. Recent studies emphasized critical role serum exosomes their miRNA content in mediating sepsis-induced dysfunction. The objective this study elucidate mechanism underlying impact miR-122-5p on sepsis-associated...
Abstract Cucurbitacin-I (Cu-I, also known as Elatericin B or JSI-124) is developed to inhibit constitutive and abnormal activation of STAT3 in many cancers, demonstrating a potent anticancer activity by targeting disruption function. Here, we for the first time systematically studied underlying molecular mechanisms Cu-I-induced gastric cancer cell death both vitro vivo . In our study, show that Cu-I markedly inhibits growth inducing G2/M phase cycle arrest apoptosis at low nanomolar...
Abstract Cancer cells consume large amounts of glucose to produce lactate, even in the presence ample oxygen. This phenomenon is called Warburg effect. c‐Myc an important member Myc gene family and involved development various tumors. It plays role regulation tumor energy metabolism, which can regulate glycolysis promote effect a tumor. Our study aimed improve malignant biological behavior by controlling metabolism gastric cancer through mTOR/PKM2 signal transduction activator 3...
Cholangiocarcinoma (CCA) is a fatal disease without effective targeted therapy. We screened small-molecule library of 116 inhibitors targeting different targets the cell cycle and discovered several kinases, including Cyclin-dependent kinase 7 (CDK7) as vulnerabilities in CCA. Analysis multiple CCA data sets demonstrated that CDK7 was overexpressed tissues. Further studies inhibitor THZ1 inhibited viability induced apoptosis cells. also showed growth xenograft model. RNA-sequencing followed...
Cholangiocarcinoma (CCA), a devastating neoplasm, is highly resistant to current chemotherapies. CCA cells frequently overexpress the antiapoptotic protein myeloid cell leukemia-1(Mcl-1), which responsible for its extraordinary ability evade death. Triptolide, bioactive ingredient extracted from Chinese medicinal plant, has been shown inhibit proliferation and induce apoptosis in several cancers. CCK-8 assay was performed detect survival rate vitro. DAPI staining Flow cytometry were used...
The matrine-type alkaloids are bioactive components extracted from Sophora flavescens, which is used in treatment of diabetes mellitus traditional Chinese medicine. Advanced glycation end products mediate diabetic vascular complications. This study was aimed to investigate the protective effects and molecular mechanisms on advanced products-induced reactive oxygen species-mediated endothelial apoptosis.Rats aorta cultured rat aortic cells were exposed products. Matrine-type alkaloids, p38...
Background and aims: Endoscopic resection is increasingly performed for gastric gastrointestinal stromal tumors (GIST).However, the safety outcomes remain elusive.We aimed in this retrospective study to compare operative complications prognosis between endoscopically surgically resected small (≤ 5 cm) GIST tumor groups.Methods: In single-center study, we compared demographics, clinical outcomes, R0 rate endoscopy (n =268) surgery =141) groups.Only size of ≤ 5.0 cm were recruited comparison...