A5103045030- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Chemokine receptors and signaling
- ATP Synthase and ATPases Research
- Axon Guidance and Neuronal Signaling
- Viral-associated cancers and disorders
- Peptidase Inhibition and Analysis
- Lipid metabolism and disorders
- Video Analysis and Summarization
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
Nanchang University
2021-2025
Second Affiliated Hospital of Nanchang University
2021-2025
Second People’s Hospital of Yibin
2024
Jiangxi Provincial Cancer Hospital
2021-2023
ORCID
2021
Ningde Normal University
2021
Nanjing University of Chinese Medicine
2020
Jiangxi Provincial People's Hospital
2019
Fujian Medical University
2018
Nanjing Drum Tower Hospital
2011-2016
PANoptosis, a programmed cell death, shares key characteristics of apoptosis, pyroptosis, and necroptosis. Accumulating evidence suggests that PANoptosis plays crucial role in tumorigenesis. However, the respective regulation mechanisms cancer are so far unclear. Using various bioinformatic approaches, we comprehensively analyzed expression patterns, genetic alterations, prognostic value, immunological genes pan-cancer. Expression gene, PYCARD, was validated based on Human Protein Atlas...
Dendritic cell (DC)-derived exosomes (Dexs) have been proved to induce and enhance antigen-specific T responses in vivo, previous clinical trials shown the feasibility safety of Dexs multiple human cancers. However, there is little knowledge on efficacy against hepatocellular carcinoma (HCC) until now.In this study, peripheral blood-derived DCs were loaded with recombinant adeno-associated viral vector (rAAV)-carrying alpha-fetoprotein (AFP) gene (rAAV/AFP), high-purity generated. Then naive...
The actin-related protein 2/3 complex (Arp2/3) is a major actin nucleator that has been widely reported and plays an important role in promoting the migration invasion of various cancers. However, expression patterns prognostic values Arp2/3 subunits hepatocellular carcinoma (HCC) remain unclear. In this study, Cancer Genome Atlas (TCGA) UCSC Xena databases were used to obtain mRNA corresponding clinical information, respectively. differential HCC analyzed using “limma” package R 4.0.4...
Hepatic arterial infusion chemotherapy (HAIC) has demonstrated remarkable local therapeutic efficacy in treating patients with large unresectable hepatocellular carcinoma (HCC). Additionally, the combination of lenvatinib and programmed cell death protein-1 (PD-1) inhibitors promising antitumor effects HCC. Therefore, we conducted a retrospective analysis to evaluate safety combining HAIC PD-1 as first-line approach high-burden HCC patients.
Abstract Cucurbitacin-I (Cu-I, also known as Elatericin B or JSI-124) is developed to inhibit constitutive and abnormal activation of STAT3 in many cancers, demonstrating a potent anticancer activity by targeting disruption function. Here, we for the first time systematically studied underlying molecular mechanisms Cu-I-induced gastric cancer cell death both vitro vivo . In our study, show that Cu-I markedly inhibits growth inducing G2/M phase cycle arrest apoptosis at low nanomolar...
Microsatellite stability (MSS) or mismatch repair proficient (pMMR) metastatic colorectal cancer (mCRC) is resistant to immune checkpoint inhibitors. Studies have shown that antiangiogenic drugs combined with programmed death receptor-1 (PD-1) inhibitors can improve immunosuppression. The purpose of this study was compare the efficacy fruquintinib PD-1 inhibitor (FP) and regorafenib (RP) in treatment advanced mCRC MSS pMMR.We retrospectively collected pMMR patient data from Second Affiliated...
Circular RNAs (circRNAs) are widely involved in diverse biological processes of cancers. Nonetheless, the potential function hsa_circ_0008305 hepatocellular carcinoma (HCC) remains largely unknown. This study aims to elucidate role and underlying mechanism HCC. Our findings reveal that novel circRNA (circPTK2) is significantly upregulated HCC tissues, with its elevated expression being positively correlated advanced tumor T stage vascular invasion. The circular characteristics subcellular...
Gastric cancer (GC) is one of the most common malignant tumors with a poor prognosis. Ferroptosis an distinct type non-apoptotic cell death that closely associated tumor Thus, we aimed to develop novel prognosis risk model based on ferroptosis-related lncRNAs and excavate diagnostic markers. In this study, eight were obtained for constructing in GC TCGA database. The patients high-risk group had worse survival than those low-risk group, risk-grouping could be used as independent prognostic...
The purpose of the study was to assess efficacy and safety in patients with advanced hepatocellular carcinoma (HCC) who are undergoing hepatic arterial infusion chemotherapy (HAIC) combined programmed cell death protein-1 (PD-1) antibody lenvatinib.
Puerarin has recently been demonstrated to play anti-cancer roles in a series of human cancers, including non-small cell lung cancer (NSCLC), possibly through regulation cancer-related microRNAs (miRNAs).The purpose the present study was further investigate detailed role and underlying mechanism puerarin on NSCLC progression.Cell viability apoptosis were assessed using Cell Counting kit-8 (CCK-8) assay flow cytometry, respectively.Transwell assays performed determine migration invasion...
Introduction: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with poor prognosis. The tumor microenvironment (TME) plays a vital role in HCC progression. Thus, this research was designed to analyze correlation between TME and prognosis patients construct TME-related long noncoding RNA (lncRNA) signature determine patients’ response immunotherapy. Methods: We assessed stromal–immune–estimate scores within using ESTIMATE (Estimation Stromal Immune Cells Malignant...
Background: Ephrins, a series of Eph-associated receptor tyrosine kinase ligands, play an important role in the tumorigenesis and progression various cancers. However, their contributions to hepatocellular carcinoma (HCC) remain unclear. Thus, we aimed explore prognostic value immune implications HCC. Methods: Multiple public databases, such as TCGA, GTEx, UCSC XENA, were used analyze expression ephrin genes across Kaplan-Meier analysis Cox regression A logistic model was utilized evaluate...
Actin-related protein 2/3 complex subunit 5 (ARPC5) is one of the members actin-related and plays an important role in cell migration invasion. However, little known about expression pattern, prognosis value, biological function ARPC5 pan-cancer. Thus, we focus on as cut point to explore a novel prognostic immunological biomarker for cancers. The public databases, including TCGA, GTEx, UCEC, were used analyze Human Protein Atlas website was applied obtain different tissues, lines,...
Previously, it has been demonstrated that HIF-1α close connection with malignant tumor progression, aggressive behavior and prognosis. In addition, proton pump inhibitors (PPIs) have reported to selectively induce cell apoptosis, thus exerting its anticancer effects. vitro in vivo our study revealed pantoprazole (PPZ) inhibited cells proliferation, induced apoptosis decreased the expression of protein. summary, PPZ could suppress growth acting as a protein inhibitor.
Disc large associated protein 4 (DLGAP4) plays an important role in neurological diseases, but the and mechanism of DLGAP4 hepatocellular carcinoma (HCC) remain unclear. In this study, prognostic effect on HCC patients was investigated by means bioinformatics. The correlation expression with prognosis evaluated TCGA data analysis, between clinical characteristics Wilcoxon signed rank test logistic regression analysis. Kaplan‒Meier Cox methods were used to assess level overall survival,...
The Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family, comprising nine members, is involved in the tumorigenesis and progression of various cancers. However, expression profiles clinical significance CMTM family members hepatocellular carcinoma (HCC) are not fully clarified. In this study, RNA-sequencing data were downloaded from Cancer Genome Atlas (TCGA) databases. Kaplan-Meier method Cox proportional hazards regression analysis used to evaluate...
e16145 Background: aHCC patients (pts) with Vp3-4 PVTT have a poor prognosis. HAIC combined immune checkpoint inhibitors and targeted therapies has shown local control survival benefits in aHCC. However, the optimal combination pts remains unclear. Here, we reported preliminary efficacy safety of tislelizumab lenvatinib this population. Methods: In ongoing, single-site, prospective, single-arm, phase II study, eligible were aged ≥18 years, histologically confirmed aHCC, ECOG PS ≤1,...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with poor prognosis. Epithelial-mesenchymal transition (EMT) crucial for cancer progression and metastasis. Thus, we aimed to construct an EMT-related lncRNA signature predicting prognosis HCC patients.Cox regression analysis LASSO method were used build lncRNAs risk based on TCGA database. Kaplan-Meier survival was conducted compare overall (OS) in different groups. ROC curves Cox proportional-hazards performed...
Background: Hepatocellular carcinoma (HCC) is a tumor with high morbidity and mortality worldwide. lysine acetylation regulators (LARs) dynamically regulate Lysine modification which plays an important regulatory role in cancer. Therefore, we aimed to explore the potential clinical prognostic value of LARs HCC. Methods: Differentially expressed normal liver HCC tissues were obtained from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) datasets. To identify genes establish risk...
Background: Actin-related protein 2/3 complex subunit 2 (ARPC2) plays a fundamental role in actin filament nucleation and is critical for tumor cell migration invasion. However, its abnormal expression, clinical significance, biological function human pan-cancer have been poorly explored. Thus, we focused on ARPC2 as an entry point identifying novel prognostic biomarkers. Methods: The Cancer Genome Atlas (TCGA) the Genotype-Tissue Expression (GTEx) databases were used to assess differential...
e20596 Background: Pemetrexed is highly active in non-small cell lung cancer (NSCLC). Rashes associated with pemetrexed are more commonly than other chemotherapies. It recommended that patients receive required dexamethasone as a pretreatment. However, the immunosuppressive effects of especially high doses glucocorticoids may reduce efficacy immune checkpoint inhibitors (ICIs). This study aims to prospectively evaluate low-dose pretreatment pemetrexed-induced rash, particularly NSCLC...
The relationship between hepatocellular carcinoma (HCC) metastasis and cancer metabolism reprogramming is becoming increasingly evident. Ubiquitin-specific protease 11 (USP11), a member of the deubiquitinating enzyme family, has been linked to various cancer-related processes. While USP11 known promote HCC proliferation, precise mechanisms, especially those related metabolism, remain unclear. Through mass spectrometry, co-immunoprecipitation, immunofluorescence, ubiquitination assays, we...