A5101403986- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Immune cells in cancer
- Hormonal and reproductive studies
- Transportation and Mobility Innovations
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cloud Computing and Resource Management
- Cancer Research and Treatments
- Urban and Freight Transport Logistics
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- Insect Utilization and Effects
- Endoplasmic Reticulum Stress and Disease
- Web Data Mining and Analysis
- Smart Grid Security and Resilience
- Mobile Crowdsensing and Crowdsourcing
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Metal and Thin Film Mechanics
Fujian Medical University
2013-2025
Fuzhou University
2025
Fujian Provincial Cancer Hospital
2013-2024
Southern Medical University
2009-2024
China Southern Power Grid (China)
2019-2024
Zhuzhou Central Hospital
2021-2024
Dalian Maritime University
2020-2022
Nanchang University
2021
Sichuan University
2021
University of Science and Technology Beijing
2019
The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released “on demand” by neurons in the brain. Anandamide also generated macrophages where its endotoxin (LPS)-induced synthesis has been implicated hypotension of septic shock advanced liver cirrhosis. can be from membrane precursor, N -arachidonoyl phosphatidylethanolamine (NAPE) through cleavage phospholipase D (NAPE–PLD). Here we document biosynthetic pathway for anandamide mouse brain...
Dendritic cell (DC)-derived exosomes (Dexs) have been proved to induce and enhance antigen-specific T responses in vivo, previous clinical trials shown the feasibility safety of Dexs multiple human cancers. However, there is little knowledge on efficacy against hepatocellular carcinoma (HCC) until now.In this study, peripheral blood-derived DCs were loaded with recombinant adeno-associated viral vector (rAAV)-carrying alpha-fetoprotein (AFP) gene (rAAV/AFP), high-purity generated. Then naive...
Transcriptional regulation by the androgen receptor (AR) requires its binding to hormone response element nucleotide sequences in DNA. A consensus glucocorticoid (GRE) can mediate transactivation AR and other members of AR/glucocorticoid (GR)/progesterone (PR)/mineralocorticoid (MR) subfamily. We identified putative (ARE) a human DNA-binding domain fusion protein DNA random sequence selection assay. 17-base pair sequence, termed IDR17, containing three potential GRE-like core sites organized...
Objective To investigate the clinical significance of expression MHC class I chain-related gene A (MICA) in patients with advanced non-small cell lung cancer and explore relationship between MICA efficacy cytokine-induced killer (CIK) therapy for treating cancer. Methods We obtained data on 222 cancer, including expression, age, gender, ECOG score, pathological type, stage, treatment history (including 38 who were given autologous CIK infusion), overall survival (OS). tissue was evaluated by...
The aim of this study was to investigate the protective effects andrographolide (AP), a bioactive component isolated from Andrographis paniculata, on carbon tetrachloride (CCl4)-induced liver injury as well possible mechanisms involved in protection mice. Acute induced by CCl4 intoxication Serum biological analysis, lipid peroxides and antioxidant estimation, histopathological studies, reverse transcription polymerase chain reaction (RT-PCR) Western blot assay were carried out. treatment...
Abstract Solasonine, a steroidal glycoalkaloid isolated from the herbal plant Solanum nigrum Linn., has shown active against multiple human cancers; however, there is little knowledge on activity of solasonine gastric cancer until now. This study aimed to examine effect biological behaviours SGC‐7901 cells. The results showed that suppressed cell proliferation in dose‐dependent manner. Solasonine treatment mainly induced cycle arrest at G2 phase Treatment with resulted significant...
Background The COMPASSION-15 trial demonstrated that cadonilimab plus chemotherapy (CAD-CHM) confers clinical benefits over placebo (PLA-CHM) as a first-line treatment for human epidermal growth factor receptor 2 (HER2)-negative advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma. However, the introduction of substantially elevates costs, and its cost-effectiveness relative to PLA-CHM remains undetermined. This study evaluates CAD-CHM compared with from perspective Chinese...
Steroid metabolism was investigated in cultured human B-lymphoblastoid cells (B-LCL), and peripheral blood T B cells. Gene expression examined by reverse-transcription polymerase chain reaction amplification (RT-PCR). Appropriate sized transcripts were detected both fresh lymphocytes for CYP11A, CYP17, HSD11L (11β-hydroxysteroid dehydrogenase I), HSD17B1 (17β-hydroxysteroid type I) SRD5A1 (5α-reductase I). B-LCL, but not cells, expressed CYP11B. There minimal of HSD3B1 HSD3B2...
A fast, sensitive and specific high-performance liquid chromatography tandem mass spectrometry method was develope for simultaneous determination of metformin rosiglitazone in human plasma. With phenformin as an internal standard, the analysis carried out on a C18 column (50 mm × 2.1 mm, 3.5 µm) using mobile phase consisting acetonitrile-10 mM ammonium acetate (20:80, v/v). The detection performed by via electrospray ionization. Linear calibration curves were obtained concentration...
Long non‑coding RNAs serve an essential role in drug resistance various types of cancer, including lung, breast and bladder cancer. The present study aimed to investigate whether KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) was associated with cisplatin (DDP) nasopharyngeal carcinoma (NPC). KCNQ1OT1, microRNA (miR)‑454 ubiquitin specific peptidase 47 (USP47) expression levels were measured via reverse transcription‑quantitative PCR. 5‑8F/DDP SUNE‑1/DDP cell viability...
<h3>Background:</h3> B-cell mediated autoimmune disease, such as systemic lupus erythematosus (SLE), can cause widespread inflammation and organ damages, even life-threatening symptoms for some severe patients. Despite tremendous progress in the clinical management of SLE, many patients do not respond to currently used treatments. Autoreactive B cells play a key role pathogenesis diseases like SLE. Recently, cases suggested that CAR-T therapies showed potential promote full remission...
Chimeric antigen receptor (CAR) T cells have been proven effective for the treatment of B-cell-mediated malignancies. Currently, development efficient tools that supply CAR other malignancies would great impact. In this study, interleukin (IL)-15 and C-C motif chemokine ligand 19 (CCL19) were introduced into natural killer group 2D (NKG2D)-based CARs to generate 15×19 cells, which remarkably increased T-cell expansion promoted production central memory (T cm ) cells. showed greater...