A5103094413- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Bioactive natural compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Prostate Cancer Treatment and Research
- Sirtuins and Resveratrol in Medicine
- Cancer, Lipids, and Metabolism
- Biological and pharmacological studies of plants
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Retinoids in leukemia and cellular processes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Probiotics and Fermented Foods
- Traditional Chinese Medicine Analysis
- Biochemical effects in animals
- PI3K/AKT/mTOR signaling in cancer
- Ginseng Biological Effects and Applications
- Immune Response and Inflammation
- Cancer Risks and Factors
First Affiliated Hospital of Zhengzhou University
2017-2024
Hebei Agricultural University
2022
Zhengzhou University
2019-2021
Guangdong Medical College
2016-2017
Integrated Chinese Medicine (China)
2017
Southwest University
2014-2016
Key Laboratory of Guangdong Province
2016
Abstract Enhancer of zeste homolog 2 (EZH2), an oncogene, is a commonly up‐regulated epigenetic factor in human cancer. Hepatocellular carcinoma deletion gene 1 (DLC1) antioncogene that either expressed at low levels or not many malignant tumours. Curcumin promising anticancer drug has antitumour effects tumours, but its mechanism action unclear. Our research demonstrated EZH2 was breast cancer (BC) tissues and cells, whereas DLC1 down‐regulated, the expression negatively correlated BC. By...
Background and Aims Arsenic trioxide (As2O3), which used as an effective agent in the treatment of leukaemia other solid tumors, is largely limited by its toxicity. QT prolongation, torsades de pointes sudden heart death have been implicated cardiotoxicity As2O3. The present study was designed to explore whether combination As2O3 resveratrol could generate a more powerful anti-cancer effect both vitro vivo. Materials Methods MTT assay performed assess proliferation Hela, MCF-7 NB4 cells....
Stressed oligodendrocytes (OLGs) activate microglia to produce an inflammatory response, and the impairment of mitochondria further aggravates OLG damage, which is earliest pathological change in multiple sclerosis (MS), demyelinating disease central nervous system. Matrine (MAT), a tetracyclic quinolizine alkaloid derived from herb radix sophorae flavescentis, has been shown effectively ameliorate clinical signs experimental autoimmune encephalomyelitis (EAE), animal model MS. However,...
Abstract The lactation capacity of dairy cows is critical to the productivity animals. Mastitis a disease that directly affects cows. Staphylococcus aureus ( S. ) one most important pathogens causes mastitis in anti-inflammatory effect Salvia miltiorrhiza polysaccharides (SMPs) has been demonstrated mice and chickens. However, effectiveness SMPs preventing treating unclear. Therefore, purpose this study was explore protective mechanism on caused by . used induce rats, three doses (87.5, 175,...
In contrast to men, women have experienced a rapid increase in lung cancer mortality. Numerous studies found that the sex differences are due reproductive hormones. Experiments female mice with and without ovariectomy were performed explore possible mechanism by which hormones (and their receptors) influence cancer.Twenty-four C57BL/6 aged 56-62 days randomly divided into ovariectomized group control group. group, bilateral ovaries removed via dorsal approach, while underwent sham operation...
Dendrobium officinale Kimura et Migo has been used for thousands of years to promote body fluid production; however, little is currently known regarding its effects on the heart. The present study aimed explore cardioprotective potential water extract (DOE) myocardial ischemia in mice. A mouse model was induced following ligation left anterior descending coronary artery. Prior operation, mice were administered a vehicle or DOE 2 weeks. Following ST elevation measured. To estimate extent...
The study was designed to explore the improvement effect of CSPCM (compound small peptide Chinese medicine) on intestinal immunity and microflora through treatment different doses CSPCM. A total 100 male Kunming mice were weighed divided into five groups, namely, group (control group), B (model C (0.1 g/kg·bw CSPCM), D (0.2 E (0.4 CSPCM). use CTX (cyclophosphamide) caused a series negative effects: secretion IL-2, IL-22, TNF-α, sIgA, length villi, area Pey's node significantly reduced (P <...
The etiology of multiple sclerosis (MS) is not clear, and the treatment MS presents a great challenge. This study aimed to investigate pathogenesis potential therapeutic targets define target genes matrine, quinolizidine alkaloid component derived from root Sophorae flavescens that effectively suppressed experimental autoimmune encephalomyelitis (EAE), an animal model MS. To this end, GSE108000 gene data set in Gene Expression Omnibus Database, which included 7 chronic active lesions 10...
Background/Aims: BushenShugan Formula (BSF) is a traditional Chinese medicine that has therapeutic effects on middle- and late-stage lung adenocarcinoma in clinical application. It was reported Bushen suppressed the onset of pre-metastatic niches murine model spontaneous metastasis. However, mechanisms BSF human remain unknown. Methods: Cell proliferation determined by CCK8 colony formation. apoptosis cell cycle were detected flow cytometry. Cancer stem cells properties examined spheroid...
Background. Hepatocellular carcinoma (HCC) remains an important cause of cancer death. The molecular mechanism hepatocarcinogenesis and prognostic factors HCC have not been completely uncovered. Methods. In this study, we screened out differentially expressed lncRNAs (DE lncRNAs), miRNAs miRNAs), mRNAs mRNAs) by comparing the gene expression normal tissue in Cancer Genome Atlas (TCGA) database. DE were used to perform Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) pathway...