A5101910977- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Single-cell and spatial transcriptomics
First Affiliated Hospital of Zhengzhou University
2020-2025
Beijing Proteome Research Center
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Zhengzhou University
2020-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024
Peking Union Medical College Hospital
2023
Academy of Medical Sciences
2023
Henan Provincial Health Bureau
2023
Central South University
2022
Xiangya Hospital Central South University
2022
Long noncoding RNAs (lncRNAs) are recently implicated in modifying immunology colorectal cancer (CRC). Nevertheless, the clinical significance of immune-related lncRNAs remains largely unexplored. In this study, we develope a machine learning-based integrative procedure for constructing consensus lncRNA signature (IRLS). IRLS is an independent risk factor overall survival and displays stable powerful performance, but only demonstrates limited predictive value relapse-free survival....
Abstract Immune checkpoint inhibitors (ICIs) have completely changed the approach pertaining to tumor diagnostics and treatment. Similarly, immunotherapy has also provided much needed data about mutation, expression prognosis, affording an unprecedented opportunity for discovering candidate drug targets screening immunotherapy-relevant biomarkers. Although existing web tools enable biologists analyze expression, mutation prognostic of tumors, they are currently unable facilitate mining...
Rationale: Accumulating evidence demonstrated that long noncoding RNAs (lncRNAs) involved in the regulation of immune system and displayed a cell-type-specific pattern cell subsets. Given vital role tumor-infiltrating lymphocytes effective immunotherapy, we explored cell-associated lncRNA (TIIClncRNA) low-grade glioma (LGG), which has never been uncovered yet. Methods: This study utilized novel computational framework 10 machine learning algorithms (101 combinations) to screen out...
Abstract Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary organs (SLOs). While TLS is generally associated with an anti-tumour response in most cancer types, it has also been observed act as a pro-tumour response. The heterogeneity largely determined by the composition tumour-infiltrating lymphocytes (TILs) balance cell subsets within tumour-associated (TA-TLS). TA-TLS varying maturity, density, location may have opposing...
Abstract Background The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME mechanisms by which affects immunotherapy have not been elucidated in hepatocellular carcinoma (HCC). Methods A total of 2195 eligible HCC patients from TCGA GEO database were collected. We comprehensively explored different phenotypes its clinical significance. potential immune escape what genomic alterations may drive formation further...
Abstract Long noncoding ribonucleic acids (RNAs; lncRNAs) have been associated with cancer immunity regulation. However, the roles of immune cell-specific lncRNAs in glioblastoma (GBM) remain largely unknown. In this study, a novel computational framework was constructed to screen tumor-infiltrating cell-associated (TIIClnc) for developing TIIClnc signature by integratively analyzing transcriptome data purified cells, GBM cell lines and bulk tissues using six machine learning algorithms. As...
As the most aggressive tumor, outcome of pancreatic cancer (PACA) has not improved observably over last decade. Anatomy-based TNM staging does exactly identify treatment-sensitive patients, and an ideal biomarker is urgently needed for precision medicine. Based on expression files 1280 patients from 10 multicenter cohorts, we screened 32 consensus prognostic genes. Ten machine-learning algorithms were transformed into 76 combinations, which selected optimal algorithm to construct artificial...
Stemness refers to the capacities of self-renewal and repopulation, which contributes progression, relapse, drug resistance colorectal cancer (CRC). Mounting evidence has established links between stemness intratumoral heterogeneity across cancer. Currently, intertumoral remains elusive in CRC.This study enrolled four CRC datasets, two immunotherapy a clinical in-house cohort. Non-negative matrix factorization (NMF) was performed decipher stemness. Multiple machine learning algorithms were...
Chronic kidney disease (CKD) is closely associated with cardiovascular disease. We aimed to examine the association of Life's Essential 8 (LE8), recently updated measurement health, prevalence CKD among US adults.
Background Ferroptosis is essential for tumorigenesis and progression of hepatocellular carcinoma (HCC). The heterogeneity ferroptosis its relationship with tumor microenvironment (TME) have still remain elusive. Methods Based on 74 related genes (FRGs) 3,933 HCC samples from 32 datasets, we comprehensively explored the heterogenous subtypes. clinical significance, functional status, immune infiltration, escape mechanisms, genomic alterations different subtypes were further investigated....
Abstract Colorectal cancer (CRC) remains a leading cause of cancer‐related deaths worldwide. Although treatment strategies for solid tumours have been revolutionized by immunotherapy, only small subset CRC patients benefit. Using two‐independent cohorts, we found the common frequently mutated genes TTN and OBSCN had significant correlation with higher tumour mutation burden (TMB) favourable overall survival. also displayed commutation phenomenon. Therefore, based on status , stratified into...