A5074864641- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Cancer Genomics and Diagnostics
- Esophageal and GI Pathology
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Vascular Anomalies and Treatments
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Dysphagia Assessment and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
First Affiliated Hospital of Zhengzhou University
2016-2025
Zhengzhou University
2013-2025
Fudan University Shanghai Cancer Center
2023
Shanxi Provincial Cancer Hospital
2023
Taizhou Central Hospital
2023
Henan Provincial Health Bureau
2023
Taizhou University
2023
Shenzhen Luohu People's Hospital
2023
Shandong University
2019-2023
GlaxoSmithKline (United States)
2022
Long noncoding RNAs (lncRNAs) are recently implicated in modifying immunology colorectal cancer (CRC). Nevertheless, the clinical significance of immune-related lncRNAs remains largely unexplored. In this study, we develope a machine learning-based integrative procedure for constructing consensus lncRNA signature (IRLS). IRLS is an independent risk factor overall survival and displays stable powerful performance, but only demonstrates limited predictive value relapse-free survival....
Abstract Data mining from RNA-seq or microarray data has become an essential part of cancer biomarker exploration. Certain existing web servers are valuable and broadly utilized, but the meta-analysis multiple datasets is absent. Most only contain tumor samples TCGA database with one cohort for each type, which also means that analysis results mainly derived a single thin unstable. Indeed, consistent performance across independent cohorts foundation excellent biomarker. Moreover, deeper...
Abstract Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary organs (SLOs). While TLS is generally associated with an anti-tumour response in most cancer types, it has also been observed act as a pro-tumour response. The heterogeneity largely determined by the composition tumour-infiltrating lymphocytes (TILs) balance cell subsets within tumour-associated (TA-TLS). TA-TLS varying maturity, density, location may have opposing...
Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit vegetables. prevents tumor proliferation by inducing cell cycle arrest well known autophagy mediator. Recent studies showed that drug delivery nanoparticles have enhanced efficacy with reduced side effects. In this regard, gold-quercetin into poly(DL-lactide-co-glycolide) was examined. study, we explored the role possible underlying mechanisms of quercetin nanoparticle regulation antitumor activity liver...
Abstract Background C-X-C motif ligand 8 (CXCL8), known as a proinflammatory chemokine, exerts multiple effects on the proliferation, invasion, and migration of tumor cells via autocrine or paracrine manner. Conversely, human Dachshund homologue 1 (DACH1) is recognized suppressor which retards progression various cancers. In prostate cancer, it has been demonstrated that DACH1 was negatively correlated with expression CXCL8 able to antagonize cellular migration. Herein, we explored...
Abstract Background The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME mechanisms by which affects immunotherapy have not been elucidated in hepatocellular carcinoma (HCC). Methods A total of 2195 eligible HCC patients from TCGA GEO database were collected. We comprehensively explored different phenotypes its clinical significance. potential immune escape what genomic alterations may drive formation further...
As the most aggressive tumor, outcome of pancreatic cancer (PACA) has not improved observably over last decade. Anatomy-based TNM staging does exactly identify treatment-sensitive patients, and an ideal biomarker is urgently needed for precision medicine. Based on expression files 1280 patients from 10 multicenter cohorts, we screened 32 consensus prognostic genes. Ten machine-learning algorithms were transformed into 76 combinations, which selected optimal algorithm to construct artificial...
Stemness refers to the capacities of self-renewal and repopulation, which contributes progression, relapse, drug resistance colorectal cancer (CRC). Mounting evidence has established links between stemness intratumoral heterogeneity across cancer. Currently, intertumoral remains elusive in CRC.This study enrolled four CRC datasets, two immunotherapy a clinical in-house cohort. Non-negative matrix factorization (NMF) was performed decipher stemness. Multiple machine learning algorithms were...
Chronic kidney disease (CKD) is closely associated with cardiovascular disease. We aimed to examine the association of Life's Essential 8 (LE8), recently updated measurement health, prevalence CKD among US adults.
Abstract Background Recently, long non-coding RNAs (lncRNAs) have been demonstrated as essential roles in tumor immune microenvironments (TIME). Nevertheless, researches on the clinical significance of TIME-related lncRNAs are limited lung adenocarcinoma (LUAD). Methods Single-cell RNA sequencing and bulk data integrated to identify lncRNAs. A total 1368 LUAD patients enrolled from 6 independent datasets. An integrative machine learning framework is introduced develop a lncRNA signature...