A5100402604- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Lung Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Cancer-related Molecular Pathways
- Urologic and reproductive health conditions
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
Central South University
2012-2025
Fuyang Normal University
2025
First Affiliated Hospital of Xinjiang Medical University
2024-2025
Xinjiang Medical University
2024-2025
Sun Yat-sen University
2010-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2010-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Jiangxi Provincial People's Hospital
2013-2025
Xiangya Hospital Central South University
2012-2025
Peking University Cancer Hospital
2014-2025
Timely intervention for cancer requires knowledge of its earliest genetic aberrations. Sequencing tumors and their metastases reveals numerous abnormalities occurring late in progression. A means to temporally order aberrations a single cancer, rather than inferring them from serially acquired samples, would define changes preceding even clinically evident disease. We integrate DNA sequence copy number information reconstruct the as individual evolve 2 separate types. detect vast, unreported...
PURPOSE ADJUVANT-CTONG1104 (ClinicalTrials.gov identifier: NCT01405079 ), a randomized phase III trial, showed that adjuvant gefitinib treatment significantly improved disease-free survival (DFS) versus vinorelbine plus cisplatin (VP) in patients with epidermal growth factor receptor ( EGFR) mutation-positive resected stage II-IIIA (N1-N2) non–small-cell lung cancer (NSCLC). Here, we report the final overall (OS) results. METHODS From September 2011 to April 2014, 222 from 27 sites were...
Abstract Circular RNAs (circRNAs) are increasingly gaining importance and attention due to their diverse potential functions value as diagnostic biomarkers (disease specific). This study aims explore the novel mechanisms by which exosome-contained circRNAs promote tumor development metastasis in TNBC. We identified increased circRNA circPSMA1 TNBC cells, exosomes, serum exosomes samples from patients. The overexpression of promoted cell proliferation, migration, both vitro vivo. Moreover, we...
As the most aggressive tumor, outcome of pancreatic cancer (PACA) has not improved observably over last decade. Anatomy-based TNM staging does exactly identify treatment-sensitive patients, and an ideal biomarker is urgently needed for precision medicine. Based on expression files 1280 patients from 10 multicenter cohorts, we screened 32 consensus prognostic genes. Ten machine-learning algorithms were transformed into 76 combinations, which selected optimal algorithm to construct artificial...
Abstract Background Most patients with ovarian cancer (OC) treated platinum-based chemotherapy have a dismal prognosis owing to drug resistance. However, the regulatory mechanisms of circular RNA (circRNA) and p53 ubiquitination are unknown in platinum-resistant OC. We aimed identify circRNAs associated OC develop novel treatment strategy. Methods Platinum-resistant were screened through circRNA sequencing validated using quantitative reverse-transcription PCR cells tissues. The...
CT lymph node distribution patterns had higher accuracy than clinical stage in diagnosing metastasis microsatellite instability–high colon cancer and predicting complete response to neoadjuvant immunotherapy.
By applying a method that combines end-sequence profiling and massively parallel sequencing, we obtained sequence-level map of chromosomal aberrations in the genome MCF-7 breast cancer cell line. A total 157 distinct somatic breakpoints two types, dispersed clustered, were identified. 89 are evenly across genome. majority regions low copy repeats (LCRs), indicating possible role for LCRs chromosome breakage. The remaining 68 form four clusters closely spaced coincide with highly amplified...
Circular RNA (circRNA) is a special type of endogenous non-coding that plays an important role in carcinogenesis. However, its biological relevance hepatocellular carcinoma (HCC) still largely uncharacterized. Here, we aimed to explore the function and clinical implication circ-FOXP1 HCC. We found was significantly upregulated HCC tissues, serum cell lines., which attributed upregulation oncogenic transcription factor SOX9. Depletion inhibited proliferation, invasion induced apoptosis....
Abstract Summary: VarSim is a framework for assessing alignment and variant calling accuracy in high-throughput genome sequencing through simulation or real data. In contrast to simulating random mutation spectrum, it synthesizes diploid genomes with germline somatic mutations based on realistic model. This model leverages information such as previously reported make the synthetic biologically relevant. simulates validates wide range of variants, including single nucleotide small indels...
9005 Background: ADJUVANT-CTONG1104, a randomized phase 3 trial showed adjuvant gefitinib treatment significantly improved disease-free survival (DFS) vs standard doublet chemotherapy in patients (pts) with epidermal growth factor receptor ( EGFR) mutation-positive resected stage II-IIIA (N1-N2) non-small-cell lung cancer (NSCLC). 5-year rate of N1N2 were 38%-50% IASLC staging system. Here, we present the final overall (OS) results from study. Methods: From Sep 2011 to April 2014, 222...
Abstract Background Circular RNA (circRNA) is emerging as an important player in human diseases, especially cancer. In our previous study, we identified a series of deregulated circRNAs hepatocellular carcinoma (HCC) by performing circRNA microarray expression profile. Here, aimed to explore the role circ-LRIG3 (hsa_circ_0027345) HCC. Methods qRT-PCR and western blot were used asses gene protein expression, respectively. CCK-8, EdU Transwell assays detect cell proliferation, migration...
To evaluate the clinical utility of cell-free DNA (cfDNA), we performed whole-genome sequencing to systematically examine plasma cfDNA copy number variations (CNVs) in a cohort patients with colorectal cancer (CRC, n = 80), polyps (n 20), and healthy controls 35). We initially compared yield 20 paired serum-plasma samples observed significantly higher concentration serum (median 81.20 ng, range 7.18-500 ng·mL-1 ) than 5.09 3.76-62.8 (P < 0.0001). However, tumor-derived content was lower...
Abstract Background The X-linked gene WTX (also called AMER1) has been reported to function as a tumour suppressor in Wilms’ tumour. In our previous study, expression was shown be significantly reduced gastric cancer (GC), but the and mechanism associated with loss had yet fully elucidated. Methods clinical significance were father analyzed GC control normal tissues, validated public databases. candidate pathway which regulated by during progression searched KEGG analysis. miRNA monitored...
Aim: We aimed to explore the roles of circular RNA, circVAPA in regulating cell migration and invasion breast cancer. Materials & methods: CircVAPA expression was detected cancer tissues cells. The role evaluated by MTT assay, wound-healing transwell assay. relationship between miR-130a-5p location were explored. Results: discovered that dysregulated Ectopic regulated migration, proliferation. mainly expressed cytoplasm could act as a miRNA sponge for miR-130a-5p, but did not regulate its...
3514 Background: Despite the fundamental role of WNT signaling in GI cancers, especially colorectal cancer (CRC), no drug targeting has been successfully developed. CGX1321, a highly-potent and selective inhibitor O-acyltransferase Porcupine, blocks ligand secretion. Preclinical studies show that CGX1321 inhibits growth tumors with RSPO fusions or inactivating RNF43 mutations. Activation associated immune-suppression resistance to immunotherapy. Methods: The first-in-human trials...
Nimotuzumab (N) is a humanized anti-epidermal growth factor receptor monoclonal antibody. This prospective, single-armed, open label phase II study was conducted to evaluate the efficacy and safety of combination paclitaxel (T)/cisplatin (P) with nimotuzumab as first-line treatment in advanced esophageal squamous cell carcinoma (ESCC). Patients pathologic confirmed unresectable locally or metastatic ESCC were treated TPN regimen: 200 mg weekly, 175 mg/m(2) on day 1 cisplatin 30 days 2;...