A5075290261- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Dementia and Cognitive Impairment Research
- RNA Research and Splicing
- Immune cells in cancer
- Bipolar Disorder and Treatment
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Folate and B Vitamins Research
- Immune Response and Inflammation
- Cardiac Health and Mental Health
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Attention Deficit Hyperactivity Disorder
- Alcoholism and Thiamine Deficiency
- Curcumin's Biomedical Applications
- Breast Cancer Treatment Studies
- Cancer survivorship and care
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2016-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Jeju National University
2021
Jiangsu Cancer Hospital
2015-2019
Second Affiliated Hospital of Nanjing Medical University
2016-2017
Jeonbuk National University
2007-2013
Chonnam National University Hospital
2005-2012
Chonnam National University
2005-2010
The role of folate, vitamin B(12) and homocysteine levels in depression is not clear.To investigate cross-sectional prospective associations between late-life depression.A total 732 Korean people aged 65 years or over were evaluated at baseline. Of the 631 persons who depressed, 521 (83%) followed a period 2-3 incident was ascertained with Geriatric Mental State schedule. Serum serum plasma assayed both baseline follow-up.Lower folate higher associated risk follow-up. Incident decline an...
This study aimed to investigate the effects of methylphenidate and sertraline compared with placebo on various neuropsychiatric sequelae associated traumatic brain injury (TBI).This was a 4 week, double-blind, parallel-group trial. Thirty patients mild moderate degrees TBI were randomly allocated one three treatment groups (n = 10 in each group) matching age, gender education, i.e. (starting at 5 mg/day increasing 20 week), 25 100 week) or placebo. At baseline week endpoint, following...
Breast cancer (BCa) is one of the major deadly cancers in women. However, treatment BCa still hindered by acquired-drug resistance. It increasingly reported that exosomes take part development, metastasis, and drug resistance BCa. specific role poorly understood. In this study, we investigate whether transmit through delivering miR-222. We established an adriamycin-resistant variant Michigan Cancer Foundation-7 (MCF-7) breast cell line (MCF-7/Adr) from a drug-sensitive (MCF-7/S). Exosomes...
Abstract Circular RNAs (circRNAs) are increasingly gaining importance and attention due to their diverse potential functions value as diagnostic biomarkers (disease specific). This study aims explore the novel mechanisms by which exosome-contained circRNAs promote tumor development metastasis in TNBC. We identified increased circRNA circPSMA1 TNBC cells, exosomes, serum exosomes samples from patients. The overexpression of promoted cell proliferation, migration, both vitro vivo. Moreover, we...
Aims: The purpose of the present paper was to evaluate effectiveness mirtazapine orally disintegrating tablets for nausea and sleep disturbance, which are common distressing symptoms cancer. Methods: This a 4‐week, prospective, open‐labeled study cancer patients. Assessments were performed at baseline on days 1, 3, 5, 7, 14, 28. Primary outcome measures Clinical Global Impression scale nausea/vomiting Chonnam National University Hospital–Leeds Sleep Evaluation Questionnaire (C‐LSEQ)...
Abstract Objective This study compared the effectiveness of risperidone and olanzapine in treatment delirium. Methods was a 7‐day, randomized, comparative clinical trial patients with The primary outcome measure Delirium Rating Scale‐Revised‐98 (DRS‐R‐98). Results We enrolled 32 subjects (median age, 70 years). Significant within‐group improvements DRS‐R‐98 scores over time were observed at every point both groups; however, differences change score from baseline not significant between...
// Shanliang Zhong 1 , Xiu Chen 2 Dandan Wang Xiaohui Zhang Hongyu Shen Sujin Yang Mengmeng Lv Jinhai Tang Jianhua Zhao Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, 210009, China Department General Surgery, Correspondence to: Zhao, e-mail: seuzsl@163.com jhzhao2838@sina.com Keywords: microvesicles, breast, cancer, chemoresistance, microRNA Received: December 02, 2015 Accepted: February 11, 2016 Published: 18, ABSTRACT Exosomes have...
Lipocalin 2 (LCN2), an innate immune protein, plays a pivotal role in promoting sterile inflammation by regulating responses. However, the of LCN2 diverse cancers remains poorly defined. This research aimed to investigate correlation between expression and immunity visualize its prognostic landscape pan-cancer.Raw data regard cancer patients were acquired from TCGA GTEx databases. Besides, we investigated genomic alterations, pattern, survival analysis pan-cancer across numerous databases,...
We aimed to investigate the role of exosomal miR-4443 in metastasis breast cancer (BCa). In vitro wound-healing assay and transwell invasion were used effect on BCa cells. Animal experiments performed confirm its effects vivo. promotes cells through downregulating tissue inhibitors metalloproteinase 2 (TIMP2) upregulating matrix metalloproteinases (MMPs). Highly invasive have a higher expression both exosomes. The exosomes derived from highly mainly gather primary tumor liver. vivo,...
Aim: To study the role of hsa_circ_0072995 in regulating invasion and migration breast cancer cells. Materials & methods: Hsa_circ_0072995 expression was confirmed by quantitative real-time PCR; evaluating cells through transwell assay; predicating circRNA/microRNAs interaction using miRanda RNAhybrid software; identifying relationship between miR-30c-2-3p luciferase activity detecting location Fluorescence situ hybridization assay. Results: significantly upregulated MDA-MB-231 compared with...
Causal relationships between vascular factors and late-life depression are controversial.To investigate prospective associations risk for disease incidence of depression.Of 661 community participants aged 65 years or over, without at baseline, 521 (79%) were re-evaluated 2 later. At baseline follow-up, a diagnostic interview was carried out information on status, disability cognitive function gathered.Pre-existing heart disease, incident stroke lower high-density lipoprotein cholesterol...
Aim: We aimed to explore the roles of circular RNA, circVAPA in regulating cell migration and invasion breast cancer. Materials & methods: CircVAPA expression was detected cancer tissues cells. The role evaluated by MTT assay, wound-healing transwell assay. relationship between miR-130a-5p location were explored. Results: discovered that dysregulated Ectopic regulated migration, proliferation. mainly expressed cytoplasm could act as a miRNA sponge for miR-130a-5p, but did not regulate its...