A5100447661- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Breast Lesions and Carcinomas
- Nanoplatforms for cancer theranostics
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Cancer and Skin Lesions
- Cervical Cancer and HPV Research
- Cancer-related Molecular Pathways
- Pneumonia and Respiratory Infections
- RNA Research and Splicing
- Respiratory viral infections research
- Estrogen and related hormone effects
- China's Ethnic Minorities and Relations
- Urban and Rural Development Challenges
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Demographic Trends and Gender Preferences
- Cancer Research and Treatments
- Protein Tyrosine Phosphatases
- Autophagy in Disease and Therapy
- Developmental Biology and Gene Regulation
- Metastasis and carcinoma case studies
Zhengzhou University
2024
Qilu Hospital of Shandong University
2014-2024
Tianjin University of Traditional Chinese Medicine
2016-2023
Peking University
2013-2023
Shandong University
2008-2022
China University of Political Science and Law
2022
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2022
West Anhui University
2022
Jiangsu Cancer Hospital
2013-2021
Nanjing Medical University
2013-2021
Background/Aims: This study aims to investigate the effect of Luteolin on breast cancer in vitro and vivo interaction between miRNAs Notch signaling after intervention, illustrates possible underlying mechanism regulation loop. Methods: Cell growth/survival assays cell cycle analyses were performed evaluate survival vitro. Scratch tests, invasion tube formation carried out analyze viability identify impact angiogenesis. Critical components pathway including proteins mRNAs detected by Western...
The tyrosine phosphorylation barcode encoded in C-terminus of HER2 and its ubiquitination regulate diverse functions. PTPN18 was reported as a phosphatase; however, the exact mechanism by which it defines signaling is not fully understood. Here, we demonstrate that regulates HER2-mediated cellular functions through defining both barcodes. Enzymologic characterization three crystal structures complex with phospho-peptides revealed molecular basis for recognition between specific sites,...
Childhood community‐acquired pneumonia (CAP) is a common illness; however, comprehensive studies of hospitalizations for CAP among children in China based on prospective and multicenter data collection are limited. The aim this investigation was to determine the respiratory pathogens responsible hospitalized children. From January December 2015, oropharyngeal swabs blood serum were collected from with symptoms ranging age 6 months 14 years at 10 hospitals across China. We used...
Objectives: miR-181a is involved in immunity, metabolism, tumor suppression or carcinogenesis reported by many other studies. However, its role the development of chemosensitivity to adriamycin low-invasive breast cancer cells remains unclear. The aim this study define function promoting efficacy adriamycin-based neoadjuvant chemotherapy. Methods: Cell survival analysis was detected Counting Kit-8 assay. Apoptotic were quantitatively using FITC Annexin V apoptosis Detection Kit I. Bcl-2...
Estrogen receptor-α (ERα) is essential for estrogen-dependent growth and its level of expression a crucial determinant response to endocrine therapy prognosis in ERα-positive breast cancer. Breast cancer patients show wide range ERα levels which change individual during disease progression systemic therapies. However, little known concerning how the regulated human Recently, several microRNAs (miRNAs) have been identified regulate predict ER, progesterone receptor (PR) epidermal factor 2...
Kinesin family member 2a (KIF2A), a type of motor protein found in eukaryotic cells, is associated with development and progression various human cancers. The role KIF2A during breast cancer tumorigenesis was studied. Immunohistochemical staining, real time RT-PCR western blot were used to examine the expression tissues adjacent normal from patients. Patients' survival relation estimated using Kaplan–Meier multivariate analysis. Breast cell line, MDA-MB-231 study proliferation, migration...
Accumulating evidence indicates that N-cadherin is a cell adhesion molecule has critical roles in tumour progression. However, the role of hepatocellular carcinoma (HCC) remains controversial. This study aims to investigate expression status and its molecular mechanisms HCC. The was markedly overexpressed HCC tissues lines. We identified miR-199b-5p binds 3′-UTR mRNA, thus decreasing cells. also found downregulation specimens, which inversely correlated with upregulation, predicted poor...
Acquired resistance to gefitinib remains a major challenge in cancer treatment. In the present study, effect of exosomes on transmission from gefitinib-resistant HCC827 lung cells (H827R) their gefitinib-sensitive counterparts and potential underlying mechanisms by which this occurs was investigated. Exosomes were obtained cell supernatant using ultracentrifugation ExoQuick-TC exosome precipitation solution. Drug assessed flow cytometry, apoptosis assays counting kit-8 assays. The expression...
Breast cancer is the most commonly diagnosed among females, and chemoresistance constitutes a major clinical obstacle to treatment of this disease. MicroRNAs (miRNAs) are related human development, progression drug resistance. To identify breast chemoresistance-associated miRNAs, miRNA microarray dataset GSE71142, including five chemoresistant tissues chemosensitive tissues, was downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed miRNAs (DE-miRNAs) were obtained...
The present study investigated the effect of triptolide on viability and apoptosis along with underlying mechanism in liver cancer cells. CCK-8 assay showed that treatment for 48 h significantly reduced HepG2 QSG7701 cells at 50 µM concentration. Annexin V-FITC propidium iodide staining concentrations induced 56.45% compared to only 2.36% control cultures. Western blot concentration phosphorylation p53 a 2 h-treatment. Phosphorylation histone H2A.X indicator DNA damage was by after 12 level...
Despite recent evidence, the role of human papillomavirus (HPV) in breast carcinogenesis is controversial. The correlations HPV infection with clinicopathological features cancer and expression cell cycle/apoptosis-associated proteins have not been well elucidated. In this study, we sought to determine prevalence high-risk HPVs (HR-HPVs) BCL2, p21, p53, Rb, survivin patients investigate relationship these cancer-related proteins, an attempt clarify potential mechanism pathogenesis. presence...
Abstract The aim of this study was to investigate the potential association between retinol intake and risk chronic kidney disease (CKD) in individuals with type 2 diabetes mellitus (T2DM). included diagnosed T2DM 2009 2018 from NHANES database. Demographic laboratory test data were collected for these individuals, as well information on CKD diagnosis. Logistic regression models utilized estimate relationship different intakes patients T2DM. A total 3988 study. mean prevalence population...
The limited efficacy of cancer immunotherapy occurs due to the lack spatiotemporal orchestration adaptive immune response stimulation and immunosuppressive tumor microenvironment modulation. Herein, we report a nanoplatform fabricated using pH-sensitive triblock copolymer synthesized by reversible addition-fragmentation chain transfer polymerization enabling in situ vaccination tumor-associated macrophages (TAMs) polarization. nanocarrier itself can induce melanoma immunogenic cell death...
AbstractThe comet assay is a single-cell gel electrophoresis technique that measures DNA damage in individual cells. Since radiation produces 3-4 times more well-oxygenated cells compared with hypoxic cells, this can quantify the fraction of radiation-resistant found many solid tumours. This paper summarizes our results 73 accessible metastatic tumours irradiated palliative intent. Hypoxic fractions ranged from 0.0 to 0.67 mean 0.15; 62% these advanced showed >0.05. Comparisons between two...
Tamoxifen and anastrozole are widely used as adjuvant treatment for early stage breast cancer, but their hepatotoxicity is not fully defined. We aimed to compare of with tamoxifen in the setting postmenopausal cancer patients. Three hundred fifty-three Chinese women hormone receptor-positive were randomized or after optimal primary therapy. The end-point was fatty liver disease, defined a liver-spleen ratio <0.9 determined using computed tomography scan. secondary end-points included...
Cancer stem cells (CSCs) are responsible for the migration and recurrence of cancer progression. Small nucleolar RNAs (snoRNAs) play important roles in tumor development. However, how snoRNAs contribute to regulation stemness ovarian CSCs (OCSCs) remains unclear. In present study, we found that SNORA72 was significantly upregulated OVCAR-3 spheroids (OS) CAOV-3 (CS) with OCSC characteristics attained by serum-free culture a suspension (OV) (CA) cells. The overexpression increased...