A5101583630- Atherosclerosis and Cardiovascular Diseases
- Ubiquitin and proteasome pathways
- Chemokine receptors and signaling
- interferon and immune responses
- Cancer-related gene regulation
- TGF-β signaling in diseases
- Breast Cancer Treatment Studies
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related molecular mechanisms research
- Biomedical Text Mining and Ontologies
- Thyroid Cancer Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Apelin-related biomedical research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer Risks and Factors
- Protein Degradation and Inhibitors
The First Affiliated Hospital, Sun Yat-sen University
2011-2022
Sun Yat-sen University
2011-2022
Shanghai Jiao Tong University
2022
Rush University Medical Center
2015
State University of New York
2010
University of Nevada, Reno
2010
SUNY Downstate Health Sciences University
2010
Tachycardia-induced atrial fibrosis is a hallmark of structural remodeling fibrillation (AF). The molecular mechanisms underlying the AF-induced remain unclear.To determine role angiotensin II (Ang II)/Ang type 1 (AT(1)) receptor-coupled transforming growth factor (TGF)-β(1)/Smad signaling pathway in fibrosis.Rapid pacing (1000 ppm) was applied to left atrium rabbit heart induce and fibrosis. Quantitative PCR Western blot analysis revealed that rapid caused marked increase expression Ang II,...
Introduction MicroRNAs play crucial roles in various types of diseases. However, to date, no information about the role miR-497 development atherosclerosis has been reported. This study investigated possible vascular endothelial cell injury during early stage atherosclerosis. Materials and Methods The expression level human umbilical vein cells (HUVECs) exposed ox-LDL was detected using qRT-PCR. To perform gain function loss analyses, mimics were transfected into HUVECs, inhibitors HUVECs...
The migration of CD4+ T cells plays an important role in arteriosclerosis obliterans (ASO). However, the molecular mechanisms involved cell are still unclear. current study is aimed to determine expression change miR-142-3p from patients with ASO and investigate its as well potential involved. We identified by qRT-PCR situ hybridization that was significantly down-regulated ASO. Chemokine (C-X-C motif) ligand 12 (CXCL12), a common inflammatory chemokine under condition, able down-regulate...
Although tamoxifen is a highly effective drug for treating estrogen receptor-positive (ER+) breast cancer, nearly all patients with metastasis initially responsive tumors eventually relapse, and die from acquired resistance. Unfortunately, few molecular mediators of resistance have been described. Here, we describe AFF3 (AF4/FMR2 family member 3), which encodes nuclear protein transactivation potential that confers enables estrogen-independent growth.We investigated expression in cancer...
Tamoxifen and anastrozole are widely used as adjuvant treatment for early stage breast cancer, but their hepatotoxicity is not fully defined. We aimed to compare of with tamoxifen in the setting postmenopausal cancer patients. Three hundred fifty-three Chinese women hormone receptor-positive were randomized or after optimal primary therapy. The end-point was fatty liver disease, defined a liver-spleen ratio <0.9 determined using computed tomography scan. secondary end-points included...
Tumor progression largely depends on blood supply and neovessel formation, angiogenesis is emerging as a promising target for cancer therapy. Vascular endothelial growth factor (VEGF), major proangiogenic molecule, stimulates via promoting proliferation, survival migration. VEGF has been found to be up-regulated in various types of tumors associated with tumor poor prognosis. Inhibition or its signaling pathway shown suppress growth. In the present study, we tested antiangiogenic antitumor...
Abstract Tamoxifen resistance remains a clinical problem in estrogen receptor (ER)-positive breast cancer. SUMOylation of ERα enhances ERα-induced transcription activity. Tripartite motif-containing (TRIM) proteins are new class SUMO E3 ligases, which regulate the proteins. However, precise molecular mechanism and function TRIM3 response to tamoxifen remain unclear. In present study, we observed that was dramatically overexpressed cancer, correlated with resistance. Furthermore,...
Abstract Background Sustaining proliferation is the most fundamental step for breast cancer tumor genesis. Accelerated usually linked to uncontrolled cell cycle. However, internal and external factors activation of cycle are still be investigated. Methods quantitative PCR (qPCR) Western blotting assay were used detect expression potassium channel tetramerization domain containing 12 (KCTD12) in cancer. MTT colony formation assays performed evaluate effect KCTD12 on Anchorage‐independent...
Ubiquitination is a major posttranslational modification of proteins that affects their stability, and E3 ligases play key role in ubiquitination by specifically recognizing substrates. BTBD9, an adaptor the Cullin-RING ligase complex, responsible for substrate recognition associated with sleep homeostasis. However, substrates BTBD9-mediated remain unknown. Here, we generated SH-SY5Y cell line stably expressing BTBD9 performed proteomic analysis combined ubiquitinome to identify downstream...
To investigate whether XRCC1 and ADPRT polymorphisms might be associated with outcomes of breast cancer.A prospective study was conducted a total 335 cancer patients undergoing chemotherapy consecutively collected from Jan. 2005 to 2008. Genotyping by PCR-RFLP assay.All were followed up until death or the end 2012, median follow-up period 38.8 (2-64) months. It shown that variant genotype 399Gln/Gln strongly significantly decreased risk cancer, an HR (95% CI) 0.52 (0.28-0.91). Similarly,...
Increasing evidence suggests that T‑cell immunoglobulin and mucin domain 3 (TIM‑3) displays anti‑atherosclerotic effects, but its role in vascular smooth muscle cells (VSMCs) has not been reported. The present study aimed to investigate the function of TIM‑3 roles human artery VSMCs (HASMCs). A protein array was used expression profile, which indicated increased serum patients with lower extremity arteriosclerosis obliterans disease (LEAOD) compared healthy individuals. Immunohistochemistry...
Abstract Background To evaluate the specificity of expression patterns microRNAs (miRNAs) in circulating CD4 + T cells aged patients with atherosclerosis obliterans (ASO). Methods A comprehensive miRNA study was conducted using a microarray isolated from peripheral blood mononuclear (PBMCs) 33 ASO and 24 healthy donors. t test used for statistical analysis, average linkage method hierarchical clustering. The results were validated by qRT–PCR. Putative targeted pathways associated miRNAs...