A5017264850- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- RNA modifications and cancer
- Gut microbiota and health
- Diet and metabolism studies
- Sleep and Wakefulness Research
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Pediatric health and respiratory diseases
- Child Nutrition and Feeding Issues
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Lipid metabolism and biosynthesis
- Genetics and Neurodevelopmental Disorders
- Cardiovascular and Diving-Related Complications
- Lipid metabolism and disorders
- Adenosine and Purinergic Signaling
- Sleep and related disorders
- Bariatric Surgery and Outcomes
Shanghai Jiao Tong University
2021-2025
Shanghai Sixth People's Hospital
2021-2025
Rationale: Previous genetic studies of obstructive sleep apnea (OSA) have limitations in terms precise case definition, integrated quantitative traits, and interpretation functions; thus, the heritability OSA remains poorly explained. Objectives: To identify novel variants associated with objective sleep-related traits to explore their functional roles. Methods: A genome-wide association study was performed 20,590 Han Chinese individuals (5,438 15,152 control samples). Human samples point...
Obstructive sleep apnea (OSA) is associated with cognitive impairment. The effects of continuous positive airway pressure (CPAP) on neuroimaging biomarkers and performance among middle-aged patients OSA normal cognition remain unclear. To investigate the CPAP therapy over 12 months performance. In this multicenter, randomized clinical trial, we randomly assigned 148 participants an apnea-hypopnea index ≥15/hour into two groups: receiving best supportive care (BSC); BSC alone. primary...
Chronic intermittent hypoxia (CIH) triggers subclinical intestinal barrier disruption prior to systemic low-grade inflammation. Increasing evidence suggests therapeutic effects of melatonin on inflammation and gut microbiota remodelling. However, whether how alleviates CIH-induced dysfunction remains unclear. C57BL/6 J mice Caco-2 cell line were treated. We evaluated function spectrophotometrically using fluorescein isothiocyanate (FITC)-labelled dextran. Immunohistochemical...
Introduction Adenoid hypertrophy is the main cause of obstructive sleep apnea in children. Previous studies have suggested that pathogenic infections and local immune system disorders adenoids are associated with adenoid hypertrophy. The abnormalities number function various lymphocyte subsets may play a role this association. However, changes proportion hypertrophic remain unclear. Methods To identify patterns adenoids, we used multicolor flow cytometry to analyze subset composition two...
Introduction Obstructive sleep apnea (OSA) has been associated with psychiatric disorders, especially depression and posttraumatic stress disorder (PTSD). FKBP5 genetic variants have previously reported to confer the risk of PTSD. This study aimed investigate association single nucleotide polymorphisms (SNPs) in gene OSA OSA-related quantitative traits. Methods Four SNPs within (rs1360780, rs3800373, rs9296158, rs9470080) were genotyped 5773 participants anthropometric polysomnography data....
Ubiquitination is a major posttranslational modification of proteins that affects their stability, and E3 ligases play key role in ubiquitination by specifically recognizing substrates. BTBD9, an adaptor the Cullin-RING ligase complex, responsible for substrate recognition associated with sleep homeostasis. However, substrates BTBD9-mediated remain unknown. Here, we generated SH-SY5Y cell line stably expressing BTBD9 performed proteomic analysis combined ubiquitinome to identify downstream...
Abstract Dyslipidemia is a hallmark of obstructive sleep apnea (OSA)-induced metabolic syndrome, yet the mechanisms remain poorly understood. We conducted genome-wide association study on lipid traits in OSA cohorts, identifying SNP rs3745683 ANGPTL8 , significantly associated with reductions multiple traits. ANGPTL8, an essential lipogenic hormone and potential therapeutic target for showed elevated expression patients compared to healthy controls, strongly correlated increased insulin...
Obstructive sleep apnea (OSA) is highly prevalent yet underdiagnosed. This study aimed to develop a predictive signature, as well investigate competing endogenous RNAs (ceRNAs) and their potential functions in OSA.The GSE135917, GSE38792, GSE75097 datasets were collected from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database. Weighted gene correlation network analysis (WGCNA) differential expression used identify OSA-specific mRNAs. Machine...
Background: Obstructive sleep apnea (OSA) is the most common type of that impacts development or progression many other disorders. Abnormal expression N6-methyladenosine (m6A) RNA modification regulators have been found relating to a variety human diseases. However, it not yet known if m6A are involved in occurrence and OSA. Herein, we aim explore impact severe Methods: We detected differentially expressed OSA microarray dataset GSE135917. The least absolute shrinkage selection operator...
Abstract Background: Chronic intermittent hypoxia (CIH) triggers subclinical intestinal barrier disruption prior to systemic low-grade inflammation. Increasing evidence suggests therapeutic effects of melatonin on inflammation and gut microbiota remodelling. However, whether how alleviates CIH-induced dysfunction remains unclear. Methods: C57BL/6J mice Caco-2 cell line were treated. We evaluated function spectrophotometrically using fluorescein isothiocyanate (FITC)-labelled dextran....
Background: Obstructive sleep apnoea (OSA) is associated with cognitive decline. The potential benefits of continuous positive airway pressure (CPAP) on performance and brain structure function in middle-aged OSA normal cognition remain unclear.Methods: In this 12-month, multicentre randomized clinical trial, we randomly assigned 148 moderate to severe into two groups: patients receiving CPAP best supportive care (BSC) BSC alone. primary endpoint was the MoCA score at 6 months after...
Background: Obstructive sleep apnoea (OSA) is a common disorder featuring intermittent hypoxia and fragmentation, which may contribute to the occurrence of cardiovascular diseases. However, its aetiology remains unclear. Emerging observational studies have revealed an association between gut microbiome OSA, but few proven causal link them.Methods: Based on results genome-wide study (GWAS) we performed two-sample mendelian randomisation analysis examine relationship OSA. Single-nucleotide...