A5072642788- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Cardiovascular and Diving-Related Complications
- Sleep and related disorders
- Retinal Development and Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Pediatric health and respiratory diseases
- RNA regulation and disease
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- Connexins and lens biology
- Nutritional Studies and Diet
- Lipid metabolism and disorders
- Advancements in Transdermal Drug Delivery
- Regulation of Appetite and Obesity
- Tracheal and airway disorders
- Acupuncture Treatment Research Studies
- Anesthesia and Pain Management
- Diet and metabolism studies
- Military Defense Systems Analysis
- Restless Legs Syndrome Research
- Alcohol Consumption and Health Effects
- Sphingolipid Metabolism and Signaling
Shanghai Sixth People's Hospital
2019-2025
Shanghai Jiao Tong University
2014-2025
Ruijin Hospital
2022-2025
Zhengzhou University of Light Industry
2024
Nanjing University of Aeronautics and Astronautics
2024
Fudan University
2024
Chengdu Fifth People's Hospital
2023
Chengdu University of Traditional Chinese Medicine
2023
West China Hospital of Sichuan University
2012-2022
Sichuan University
2009-2022
Grayscale image processing is a key research area in the field of computer vision and analysis, where quality visualization effects may be seriously damaged by high-density salt pepper noise. A traditional median filter for noise removal result poor detail reservation performance under strong judgment different characteristics has dependence rather weak robustness. In order to reduce on when high-noise grayscale images, an improved two-dimensional maximum Shannon entropy (TSETMF) proposed...
Chronic intermittent hypoxia (CIH) and chronic sleep fragmentation (CSF) are two cardinal pathological features of obstructive apnea (OSA). Dietary obesity is a crucial risk intermediator for OSA metabolic disorders. Gut microbiota affect hepatic adipose tissue morphology under conditions CIH or CSF through downstream metabolites. However, the exact relationship unclear. Herein, chow high-fat diet (HFD)-fed mice were subjected to 10 weeks each compared normoxia (NM) normal (NS) controls. 16S...
The organelle network is a key factor in the repair and regeneration of lesion. However, effectively intervening which has complex interaction mechanisms challenging. In this study, on basis electromagnetic laws, we constructed biomaterial-based physical/chemical restraint device. This device was designed to jointly constrain electrical biological factors conductive screw-threaded microneedle (ST-needle) system, identifying dual positioning regulation network. unique physical properties...
Obstructive sleep apnea (OSA) is associated with cognitive impairment. The effects of continuous positive airway pressure (CPAP) on neuroimaging biomarkers and performance among middle-aged patients OSA normal cognition remain unclear. To investigate the CPAP therapy over 12 months performance. In this multicenter, randomized clinical trial, we randomly assigned 148 participants an apnea-hypopnea index ≥15/hour into two groups: receiving best supportive care (BSC); BSC alone. primary...
Rationale: Previous genetic studies of obstructive sleep apnea (OSA) have limitations in terms precise case definition, integrated quantitative traits, and interpretation functions; thus, the heritability OSA remains poorly explained. Objectives: To identify novel variants associated with objective sleep-related traits to explore their functional roles. Methods: A genome-wide association study was performed 20,590 Han Chinese individuals (5,438 15,152 control samples). Human samples point...
Lesion positioning therapy optimizes medical treatment by directly targeting lesions. However, strong physical barriers greatly hinder its wide use. Here, the Chinese acupuncture needles (CA-needles) with a screw-thread structure at tip (ST-needle) and hydrogel function of adhesive metal loaded drug sustained-release are designed, through minimally invasive precise lesions ST-needles, dry-wet conversion absorbing fluids swelling, rotation back is precisely positioned in subchondral bone...
Objective: We assessed the serum glucagon-like peptide-1 (GLP-1) levels for Chinese adults with pre-diabetes (PD) and newly-diagnosed diabetes mellitus (NDDM) during oral glucose tolerance test (OGTT).The relationships between total GLP-1 level islet β cell function, insulin resistance (IR) sensitivity (IS) were also investigated.Methods: A 75g OGTT was given to 531 subjects.Based on results, they divided into groups of normal (NGT), isolated impaired fasting (IFG), (IGT), IFG combined IGT...
Abstract The localization of lesion cells and targeted regulation organelle function can promote the repair. However, conventional is difficult to reach deep lesions target mitochondria. In this study, dynamic spiral Mosaic technology ued construct heat transfer microneedles with micro/nano hydrogel microspheres (ST‐needle), using molecular chain motion in response stimulation regulate adhesion non‐oriented triblock polymer, as a dual delivery system for energy biological factors. ST‐needle...
<title>Abstract</title> Background Although numerous studies have demonstrated the positive relationships between apnea-hypopnea index (AHI), micro-arousal (MAI) and glucose metabolism, associations sleep fragmentation during REM-phase NREM-phase abnormal metabolism is not clear yet. Methods Subjects with initially suspected obstructive apnea (OSA) in Shanghai Sleep Health Study (SSHS) were selected. For each subject, MAI-REM MAI-NREM data from overnight standard polysomnography; fasting...
Imitating the multinodal structures of plants and arthropods, precisely engineered multisegment nanostructures demonstrate enhanced synergistic properties exceptional functionalities that surpass those individual components. Utilizing micelle assemblies for constructing segments allows precise structural control but requires management interactions assembly from molecular to mesoscopic levels, posing a significant challenge. In this paper, we present stepwise self-assembly strategy fabricate...
Background Several clinical studies have demonstrated that pediatric obstructive sleep apnea (OSA) is associated with dysbiosis of airway mucosal microbiota. However, how oral and nasal microbial diversity, composition, structure are altered in OSA has not been systemically explored.Methods 30 polysomnography-confirmed patients adenoid hypertrophy, controls who did were enrolled. Swabs from four surface tissue sites (tongue base, soft palate, both palatine tonsils, adenoid) one swab anterior...
Abstract Objectives Obstructive sleep apnea (OSA) is associated with abnormal glucose and lipid metabolism. However, whether there an independent association between Sleep Apnea-Specific Hypoxic Burden (SASHB) glycolipid metabolism disorders in patients OSA unknown. Methods We enrolled 2,173 participants suspected from January 2019 to July 2023 this study. Polysomnographic variables, biochemical indicators, physical measurements were collected each participant. Multiple linear regression...
Abstract It is a great challenge to integrate incompatible subunits into ordered macroscopic materials with tailored functionalities. Herein, facile modular assembly strategy demonstrated link colloidal nanocrystals and polymer micelles by using the phenolic resol as “molecule glue” for synthesis of nanocrystal‐inserted mesoporous frameworks diverse found that uniform can be inserted outstanding spatial dispersity, even in case high incorporation density. This route versatile, library...
Both obstructive sleep apnea (OSA) and decreased serum lipoprotein(a) (Lp(a)) concentrations are associated with insulin resistance. However, their interaction effect on resistance has never been investigated. Therefore, we performed a cross-sectional study OSA-suspected Chinese Han participants. Laboratory-based polysomnographic variables, biochemical indicators, anthropometric measurements, medical history were collected. Linear regression binary logistic analyses terms used to investigate...
BACKGROUND Ultrasound-guided posterior lumbar plexus block is widely used for hip fracture surgery but it requires a change of position, which may be painful. OBJECTIVES Our primary objective was to describe new technique, the anterior iliopsoas muscle space block, can performed in supine and test hypothesis that its analgesia similar traditional block. DESIGN Randomised, double-blind study. SETTING Shanghai 6th People's Hospital, China, from February August 2019. PATIENTS Forty-eight...
Objective Roux-en-Y gastric bypass (RYGB) surgery is an effective type of weight loss management and may improve obesity-related obstructive sleep apnea (OSA). Obese subjects who meet the criteria for with OSA were enrolled. We investigated metabolomic effects RYGB on OSA. Methods Clinical data, serum measurements including indices glycolipid metabolism, polysomnography (PSG) collected at baseline 6 months after surgery. Metabolomic analysis was performed using ultra-performance liquid...
Obesity is strongly correlated with the pathogenesis of obstructive sleep apnea (OSA); myokines may play important roles in this condition. We performed a body mass index- (BMI) and physical activity- (PA) matched study to explore relationship between irisin level OSA. Ninety-six consecutive participants were recruited. After matching terms BMI PA, 28 OSA patients healthy controls finally included. Whole-night laboratory-based polysomnography was used identify The Recent Physical Activity...