A5074285894- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Cardiovascular and Diving-Related Complications
- Radiomics and Machine Learning in Medical Imaging
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Pediatric health and respiratory diseases
- Head and Neck Cancer Studies
- Sleep and related disorders
- Heart Rate Variability and Autonomic Control
- Gut microbiota and health
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Sleep and Work-Related Fatigue
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- Spinal Hematomas and Complications
- Advanced Sensor Technologies Research
- Cardiovascular Syncope and Autonomic Disorders
Shanghai Sixth People's Hospital
2020-2025
Shanghai Jiao Tong University
2016-2025
Sun Yat-sen University
2017-2024
Key Laboratory of Guangdong Province
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
First People's Hospital of Foshan
2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2022
Beijing University of Chinese Medicine
2022
Panyu District Central Hospital
2020
The First People's Hospital of Shunde
2018
Chronic intermittent hypoxia (CIH) and chronic sleep fragmentation (CSF) are two cardinal pathological features of obstructive apnea (OSA). Dietary obesity is a crucial risk intermediator for OSA metabolic disorders. Gut microbiota affect hepatic adipose tissue morphology under conditions CIH or CSF through downstream metabolites. However, the exact relationship unclear. Herein, chow high-fat diet (HFD)-fed mice were subjected to 10 weeks each compared normoxia (NM) normal (NS) controls. 16S...
BackgroundFor patients with early-stage breast cancers, neoadjuvant treatment is recommended for non-luminal tumors instead of luminal tumors. Preoperative distinguish between and cancers at early stages will facilitate decisions making. However, the molecular immunohistochemical subtypes based on biopsy specimens are not always consistent final results surgical due to high intra-tumoral heterogeneity. Given that, we aimed develop validate a deep learning radiopathomics (DLRP) model...
Head and neck cancer (HNC) exerts a significant healthcare burden worldwide. Insufficient data impedes comprehensive understanding of its global impact. Through analysis the 2019 Global Burden Disease (GBD) database, our secondary investigation unveiled surging incidence HNC, yet decline in associated mortality disability-adjusted life years (DALYs) owing to enhanced prognosis. Particularly noteworthy is higher escalation among females compared males. Effective resource allocation,...
Multilevel upper airway surgery is effective for some patients with obstructive sleep apnea (OSA), but prediction the response to remains a challenge. The underlying endotypes of OSA include collapsibility, muscle compensation, loop gain, and arousal threshold. This study aimed explore effect on polysomnography (PSG)-derived establish surgical model. Our included 54 Chinese who underwent multilevel surgery. Participants PSG before after median follow-up time 6.5 months. Using...
Significance Mesenchymal stem cells (MSCs) are thought to be derived from pericytes and exhibit a cellular, autonomous antimicrobial effector function that provides therapeutic potential against infectious diseases. However, the molecular mechanism remains unknown. Here, we demonstrate human guanylate-binding protein 1 (hGBP1) is key protective factor Toxoplasma gondii infection in MSCs (hMSCs). The recruitment of hGBP1 parasitophorous vacuole membrane IFN-γ–stimulated hMSCs significantly...
Mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of acute respiratory distress syndrome (ARDS). However, there is significant heterogeneity in their therapeutic efficacy, largely owing to the incomplete understanding mechanisms underlying activities MSCs. Here, we hypothesize that cholinergic anti-inflammatory pathway (CAP), which recognized as neuroimmunological pathway, may be involved by MSCs mitigate ARDS. Using lipopolysaccharide (LPS) and...
BackgroundPositional OSA (POSA) is a recognized subtype of that exhibits distinct endotypic characteristics when compared with nonpositional (NPOSA). The basis for the disparity in endotypes between these subtypes remains poorly understood.Research Question(1) Do individuals NPOSA and POSA have different underlying endotypes? (2) Which are critical determining severity?Study Design MethodsWithin Shanghai Sleep Health Study cohort, were recruited classified as having or NPOSA. Endotypes...
This study aimed to explore the epidemiological trends of laryngeal cancer (LC) using 2021 Global Burden Disease (GBD) data. We analyzed global LC incidence, deaths, disability-adjusted life years (DALYs), and risk factors from 1990 2021. evaluated annual percentage change (EAPC) examined variations associations in burden across regions, sociodemographic index (SDI) categories, age groups. In 2021, age-standardized incidence rate (ASIR) for was 2.293 (95% UI: 2.133–2.466), death (ASDR) 1.35...
Obstructive sleep apnea (OSA) is associated with cognitive impairment. The effects of continuous positive airway pressure (CPAP) on neuroimaging biomarkers and performance among middle-aged patients OSA normal cognition remain unclear. To investigate the CPAP therapy over 12 months performance. In this multicenter, randomized clinical trial, we randomly assigned 148 participants an apnea-hypopnea index ≥15/hour into two groups: receiving best supportive care (BSC); BSC alone. primary...
To evaluate the prevalence, characteristics, and respiratory arousal threshold (ArTH) of Chinese patients with positional obstructive sleep apnea (POSA) according to Cartwright Classification (CC) Amsterdam Positional Obstructive Sleep Apnea (APOC).A large-scale cross-sectional study was conducted in our center from 2007 2018 analyze clinical polysomnography (PSG) data POSA patients. Low ArTH defined based on PSG indices.Of 5,748 OSA patients, 36.80% met CC criteria, 42.88% APOC for POSA....
Breast cancer (BC) is the most commonly diagnosed in women. Tumor recurrence and metastasis are key causes of death BC patients. Long non-coding RNA (lncRNA) closely associated with progression. lncRNA nuclear-enriched abundant transcript (NEAT)1 has been reported to regulate proliferation mobility several types cells. However, how NEAT1 affects invasion cells not known.Quantitative real time-polymerase chain reaction (qRT-PCR) was used measure expression microRNA (miR)-146b-5p tissues cell...
Chronic intermittent hypoxia (CIH) triggers subclinical intestinal barrier disruption prior to systemic low-grade inflammation. Increasing evidence suggests therapeutic effects of melatonin on inflammation and gut microbiota remodelling. However, whether how alleviates CIH-induced dysfunction remains unclear. C57BL/6 J mice Caco-2 cell line were treated. We evaluated function spectrophotometrically using fluorescein isothiocyanate (FITC)-labelled dextran. Immunohistochemical...
Intestinal barrier dysfunction and systemic inflammation are common in obstructive sleep apnoea (OSA). We aimed to investigate the role of melatonin, an anti-inflammatory mediator, mediating relationships between OSA, intestinal inflammation.
Background Several clinical studies have demonstrated that pediatric obstructive sleep apnea (OSA) is associated with dysbiosis of airway mucosal microbiota. However, how oral and nasal microbial diversity, composition, structure are altered in OSA has not been systemically explored.Methods 30 polysomnography-confirmed patients adenoid hypertrophy, controls who did were enrolled. Swabs from four surface tissue sites (tongue base, soft palate, both palatine tonsils, adenoid) one swab anterior...
In our large-scale study, the correlation between obstructive sleep apnea (OSA) related to rapid eye movement (REM) and cardiac autonomic dysfunction was assessed by standard polysomnography (PSG). Cardiac evaluated measurement of heart rate variability (HRV). The cardiovascular disease (CVD) risk determined using cross-sectional prevalence CVD its overall 10 year according Framingham score (FRS). 4152 individuals were included in study. A higher apnea-hypopnea index during REM (AHIREM )...
We explored whether a new combination of eye mask sleep position therapy (SPT) and oral appliance (OAT) was more effective at treating positional obstructive apnea (POSA) than the use either device alone.In this randomized controlled trial, 60 POSA subjects diagnosed by standard polysomnography (PSG) were divided into three groups (ratio 1:1:1): SPT, OAT, SPT combined with OAT (SOT). Participants underwent hospital-based follow-ups during months 1 6 after beginning treatment. The primary...
We investigated the associations between multiple sleep dimensions in obstructive apnea (OSA) and carotid intima-media thickness (CIMT), an early sign of atherosclerosis, participants from Shanghai Sleep Health Study.
Obesity is strongly correlated with the pathogenesis of obstructive sleep apnea (OSA); myokines may play important roles in this condition. We performed a body mass index- (BMI) and physical activity- (PA) matched study to explore relationship between irisin level OSA. Ninety-six consecutive participants were recruited. After matching terms BMI PA, 28 OSA patients healthy controls finally included. Whole-night laboratory-based polysomnography was used identify The Recent Physical Activity...
Objective Roux-en-Y gastric bypass (RYGB) surgery is an effective type of weight loss management and may improve obesity-related obstructive sleep apnea (OSA). Obese subjects who meet the criteria for with OSA were enrolled. We investigated metabolomic effects RYGB on OSA. Methods Clinical data, serum measurements including indices glycolipid metabolism, polysomnography (PSG) collected at baseline 6 months after surgery. Metabolomic analysis was performed using ultra-performance liquid...
Studies have shown that obstructive sleep apnea (OSA) is inextricably linked with cardiovascular diseases (CVD). However, the roles of certain common disturbances, such as low slow-wave sleep, excessive daytime sleepiness and short duration, in pathogenesis progression CVD patients OSA not been determined. Therefore, we conducted a large cross-sectional study to explore effect duration on risk OSA.Subjects were consecutively enrolled participate center Shanghai Jiao Tong University...
Autonomic dysfunction is an independent risk factor for cardiovascular disease (CVD). Both obesity and obstructive sleep apnea (OSA) are associated with heart rate variability (HRV) (a hall marker of sympathetic arousal) increased CVD. This study aims to investigate whether anthropometric parameters could predict reduced HRV in adult OSA during wakefulness.Cross-sectional study.Sleep center Shanghai Jiao Tong University Affiliated Sixth Hospital from 2012 2017.Total 2134 subjects (503...
Slow-wave sleep (SWS) and obstructive apnea (OSA) have attracted recent research attention. However, their joint effects on insulin resistance (IR) remain unclear. This study explored whether SWS influences the relationship between OSA IR.We enrolled potential participants in our center from 2007 to 2019. We collected demographic clinical characteristics determined IR status. was derived polysomnography data. Logistic regression analysis used reveal associations IR.In all, 6966 (5709 1257...
Misdiagnosis and missed diagnosis of sleep-disordered breathing (SDB) is common because polysomnography (PSG) time-consuming, expensive, uncomfortable. The use recording methods based on the oxygen saturation (SpO2) signals detected by wearable devices impractical inaccurate for extracting signal features detecting apnoeic events. We propose a method to automatically detect apnoea-based SpO2 segments compute apnoea-hypopnea index (AHI) SDB screening grading.First, apnoea-related desaturation...