A5038016936- Cancer, Hypoxia, and Metabolism
- Diet, Metabolism, and Disease
- Semantic Web and Ontologies
- Liver Disease Diagnosis and Treatment
- Mesenchymal stem cell research
- Angiogenesis and VEGF in Cancer
- Natural Language Processing Techniques
- Immune cells in cancer
- Biomedical Text Mining and Ontologies
- Metabolism, Diabetes, and Cancer
- Head and Neck Cancer Studies
- Molecular Sensors and Ion Detection
- Chemokine receptors and signaling
- Advanced Wireless Network Optimization
- Advanced Database Systems and Queries
- Luminescence and Fluorescent Materials
- Cancer Research and Treatments
- Traditional Chinese Medicine Analysis
- Cooperative Communication and Network Coding
- Immune Cell Function and Interaction
- Advanced MIMO Systems Optimization
- Neuroscience of respiration and sleep
- Hematopoietic Stem Cell Transplantation
- Mindfulness and Compassion Interventions
- T-cell and B-cell Immunology
Sun Yat-sen University
2015-2025
Guizhou University
2023-2024
Shanghai Tenth People's Hospital
2022-2024
Tongji University
2022-2024
Nanjing Medical University
2024
Guangzhou University of Chinese Medicine
2022-2023
Fudan University
2023
Sun Yat-sen University Cancer Center
2023
Beijing Normal University
2022-2023
South China Normal University
2022-2023
Interleukin-6 (IL-6) has been reported to stimulate myeloid-derived suppressor cells (MDSCs) in multiple cancers, but the molecular events involved this process are not completely understood. We previously found that cancer-derived IL-6 induces T cell suppression of MDSCs vitro via activation STAT3/IDO signaling pathway. In study, we aimed elucidate underlying mechanisms. primary breast cancer tissues, was positively correlated with infiltration situ, which accompanied by more aggressive...
Abstract The bottom-up molecular science research paradigm has greatly propelled the advancement of materials science. However, some organic molecules can exhibit markedly different properties upon aggregation. Understanding emergence these and structure-property relationship become a new hotspot. In this work, by taking unique closed-form rhodamines-based aggregation-induced emission (AIE) system as model compounds, we investigated their luminescent underlying mechanism deeply from top-down...
Mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of acute respiratory distress syndrome (ARDS). However, there is significant heterogeneity in their therapeutic efficacy, largely owing to the incomplete understanding mechanisms underlying activities MSCs. Here, we hypothesize that cholinergic anti-inflammatory pathway (CAP), which recognized as neuroimmunological pathway, may be involved by MSCs mitigate ARDS. Using lipopolysaccharide (LPS) and...
Abstract Angiogenesis is vital for tumor growth and metastasis. Emerging evidence suggests that metabolic reprogramming in endothelial cells (EC) may affect angiogenesis. Here, we showed multiple regulators the fructose metabolism pathway, especially transporter SLC2A5 fructose-metabolizing enzyme ketohexokinase (KHK), were upregulated from hepatocellular carcinoma (HCC). In mouse models with hepatoma xenografts or Myc/sgp53-induced liver cancer, dietary enhanced angiogenesis, growth,...
Abstract Major depressive disorder (MDD) is one of the most common and disabling mental disorders, current strategies remain inadequate. Although mesenchymal stromal cells (MSCs) have shown beneficial effects in experimental models depression, underlying mechanisms elusive. Here, using murine depression models, we demonstrated that MSCs could alleviate anxiety-like behaviors not due to a reduction proinflammatory cytokines, but rather activation dorsal raphe nucleus (DRN) 5-hydroxytryptamine...
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<div>Abstract<p>Emerging evidence suggests that TGFβ1 can inhibit angiogenesis, contradicting the coexistence of active angiogenesis and high abundance in tumor microenvironment. Here, we investigated how tumors overcome antiangiogenic effect TGFβ1. treatment suppressed physiologic chick chorioallantoic membrane zebrafish models but did not affect mouse hepatoma xenografts. The suppressive on was recovered xenografts by a hypoxia-inducible factor 1α (HIF1α) inhibitor. In...
In a downlink orthogonal frequency division multiple access (OFDMA) system, optimally allocating sub-channels across mobile users can require excessive feedback of channel state information (CSI). We consider an OFDMA model in which the overhead is explicitly taken into account, given fixed rate and finite coherence time. The tradeoff between sum capacity studied for two limited schemes: sequential scheme send compressed bits over consecutive time slots, contention their via random protocol....
<h2>Summary</h2> Mesenchymal stromal cells (MSCs) have shown significant heterogeneity in terms of therapeutic efficacy for inflammatory bowel disease (IBD) treatment, which may be due to an insufficient number MSCs homing the damaged tissue colon. Engineering with specific chemokine receptors can enhance ability by lentiviral transduction. However, unclear profile related IBD and safety concerns viral-based gene delivery limit its application. Thus, a new strategy modify express using mRNA...
Danggui Buxue Decoction (DBD) is a classic prescription of traditional Chinese medicine that mainly used for treating clinical anemia more than 800 years. This has been utilized nourishing "Qi" and enriching "Blood" women suffering from menopausal symptoms. Meanwhile, DBD the role improving angiogenesis promoting neuroprotective functions. Bone marrow-derived endothelial progenitor cells (EPCs) was suboptimal to treat focal cerebral ischemia (FCI). Thus, it's may be novel strategy combined...
This paper addresses the critical need for detecting bias in government documents, an underexplored area with significant implications governance. Existing methodologies often overlook unique context and far-reaching impacts of governmental potentially obscuring embedded biases that shape public policy citizen-government interactions. To bridge this gap, we introduce Dutch Government Data Bias Detection (DGDB), a dataset sourced from House Representatives annotated by experts. We fine-tune...
Owing to lack of data from multiple air quality monitoring stations, studies about spatial association between concentrations ambient pollutants and mortality in China are rare. To investigate the variation particulate matter less than 10 μm aerodynamic diameter (PM10), nitrogen dioxide (NO2) carbon monoxide (CO) cardiovascular Beijing, China, we collected including daily deaths, PM10, NO2 CO, meteorological factors 1 January 2009 31 December 2010 all 16 districts Beijing. Generalized...
IL-6 is an important trigger for the expansion and recruitment of myeloid-derived suppressor cells (MDSCs), which are regarded to be major coordinators immunosuppressive tumor microenvironment. In this study, we constructed IL-6-knockdown breast cancer mice models explore molecular events involved in IL-6-mediated effect on MDSC development. We defined a subset early-stage MDSCs (e-MDSCs) tissues containing CD11b+Gr-1-F4/80-MHCII- immature phenotype that skewed acquire monocytic upon GM-CSF...
Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating inflammatory bowel disease (IBD), and intraperitoneal delivery of MSCs have become a more effective route for IBD treatment. However, the underlying mechanisms are still poorly understood. Here, we found that intraperitoneally delivered significantly alleviated experimental colitis. Depletion peritoneal B cells, but not macrophages, clearly impaired effects MSCs. Intraperitoneally improved likely by boosting...
The Pan-Pearl River Basin (PPRB) has acted as a pioneer region of China's reform and opening-up with rapid economic development. Quantitatively clarifying the evolution ecological carrying capacity (ECC) is vital for sustainable development PPRB. Therefore, this study combined comprehensive evaluation method pressure-state-response (PSR) index system footprint based on net primary productivity (EF-NPP) to analyze spatial temporal (CECC) in PPRB from 2002 2019 economy society. random forest...
Heterogeneity and limited comprehension of chronic autoimmune disease pathophysiology cause accurate diagnosis a challenging process. With the increasing resources single-cell sequencing data, reasonable way could be found to address this issue. In our study, with use large-scale public RNA (scRNA-seq) analysis dataset integration (3.1 × 10 5 PBMCs from fifteen SLE patients eight healthy donors) cellular cross talking (3.8 twenty-eight were performed identify most crucial information...
Obesity is often accompanied by metabolic disorder and insulin resistance, resulting in type 2 diabetes. Based on previous findings, FYGL, a natural hyperbranched proteoglycan extracted from the G. lucidum fruiting body, can decrease blood glucose reduce body weight diabetic mice. In this article, underlying mechanism of FYGL ameliorating obesity-induced diabetes was further investigated both vivo vitro. upregulated expression genes related to fatty acid biosynthesis, β-oxidation...
Salicylic acid (SA) is one of the chemical molecules, involved in plant growth and immunity, thereby contributing to control pests pathogens, even applied fruit vegetable preservation. However, only a few tools have ever been designed or executed understand physiological processes induced by SA its function immunity residue detection food. Hence, three Rh6G-based fluorogenic chemosensors were synthesized detect phytohormone based on "OFF-ON" mechanism. The probes showed high selectivity,...