A5101998899- Caveolin-1 and cellular processes
- Peroxisome Proliferator-Activated Receptors
- Systemic Lupus Erythematosus Research
- Metabolism and Genetic Disorders
- Landslides and related hazards
- Mechanical Circulatory Support Devices
- Cerebrovascular and Carotid Artery Diseases
- Autophagy in Disease and Therapy
- Exercise and Physiological Responses
- Cardiac Structural Anomalies and Repair
- Diabetes and associated disorders
- Cytokine Signaling Pathways and Interactions
- Mitochondrial Function and Pathology
- Rock Mechanics and Modeling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Geotechnical Engineering and Analysis
- Cardiovascular Health and Disease Prevention
- Cardiac Ischemia and Reperfusion
- Lipid metabolism and disorders
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Dam Engineering and Safety
- Pediatric health and respiratory diseases
China Three Gorges University
2005-2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
West China Hospital of Sichuan University
2017-2024
Affiliated Hospital of Southwest Medical University
2020-2024
Sichuan University
2017-2024
Second Military Medical University
2016-2024
Guiyang Medical University
2023
Second Xiangya Hospital of Central South University
2020-2021
Central South University
2020-2021
The acute-phase protein orosomucoid (ORM) exhibits a variety of activities in vitro and vivo, notably modulation immunity transportation drugs. We found this study that mice lacking ORM1 displayed aberrant energy homeostasis characterized by increased body weight fat mass. Further investigation ORM, predominantly ORM1, is significantly elevated sera, liver, adipose tissues from the with high-fat diet (HFD)-induced obesity db/db develop spontaneously due to mutation leptin receptor (LepR)....
Abstract Extensive high, steep and perilous rocky slopes are present on both sides of the Three Gorges Reservoir area, with numerous such interspersed. The rock mass structure this type dangerous slope is complex, strongly affecting stability masses in region. Hence, it necessary to establish a detailed 3D geological model combination internal structural characteristics mass. Taking Jianchuandong 3# (JDRM 3#) area as an example, study integrated UAV photogrammetry technology laser scanning...
Danggui Buxue Decoction (DBD) is a classic prescription of traditional Chinese medicine that mainly used for treating clinical anemia more than 800 years. This has been utilized nourishing "Qi" and enriching "Blood" women suffering from menopausal symptoms. Meanwhile, DBD the role improving angiogenesis promoting neuroprotective functions. Bone marrow-derived endothelial progenitor cells (EPCs) was suboptimal to treat focal cerebral ischemia (FCI). Thus, it's may be novel strategy combined...
BACKGROUND Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive forms liver cancer, with high morbidity poor prognosis due to late diagnosis limited treatment options. Despite advances in understanding its molecular mechanisms, effective biomarkers for early detection targeted therapy remain scarce. Zinc finger protein 71 (ZNF71), a zinc-finger protein, has been implicated various cancers, yet role HCC remains largely unexplored. This gap knowledge underscores need...
We found previously that acute phase protein orosomucoid reacts to fatigue and activates C-C chemokine receptor type 5 increase muscle glycogen storage enhance endurance (Lei et al., 2016). To explore the underlying molecular mechanisms, we investigated role of AMP-activated kinase, a critical fuel sensor in skeletal muscle, 5-mediated action. It was increased kinase activation time- dose- dependent manner, which largely prevented by pharmacological blocking or knockout 5. Administration...
IL-38 is a newly identified cytokine that belongs to the IL-1 family. In our previous study, we found elevated plasma levels of in patients with systemic lupus erythematosus (SLE). However, clear relationship expression plasma, peripheral blood mononuclear cells (PBMCs) and clinical laboratory features needs elucidation. Additionally, evaluated possible role regulating production inflammatory cytokines PBMCs vitro. A pristane-induced murine model was used further demonstrate effects on vivo...
Gender differences in fatigue manifest as females being more prone to feel exhaustion and having lower muscle endurance. However, the mechanisms of these effects remain unclear. We investigated whether orosomucoid, an endogenous anti-fatigue protein that enhances endurance, is involved this regulation. Female rats exhibited gender difference disappeared orosomucoid-1-deficient mice. also weaker orosomucoid induction serum, liver response compared with male rats. Ovariectomy elevated levels...
<h3>Objective</h3> This study was conducted to determine whether the administration of intralipid just before aortic cross-unclamping would reduce myocardial injury in patients undergoing valve replacement surgery. <h3>Methods</h3> Seventy-three adult patients, scheduled for elective or mitral surgery without significant coronary stenosis (>70%), were randomly assigned postconditioning (ILPC) group (n=37) control (n=36): ILPC received an intravenous infusion 20% (2 mL/kg) 10 min...
It is important that the residual bowel adapts after massive resection. The necessary intestinal adaptation a progressive recovery from failure through increase in absorptive surface area and functional capacity includes both morphological adaptations.The aim of this study was to investigate adaptations small syndrome (SBS) model rats (SBS1W) 7 days resection.Male sprague-dawley (n = 20/group) underwent either 75% proximal resection (SBS1W group) or control operation (control group). Markers...
To assess the synergistic action of famotidine (FMD) and chlorpheniramine (CPA) on acetic acid-induced chronic gastric ulcer in rats.Chronic lesions were induced male Sprague-Dawley (SD) rats by serosal application acid. Forty SD randomly divided into blank group (n = 8), control FMD CPA FMD+CPA 8). Each was given intraperitoneally (i.p.) 0.5 mL/100 g distilled water, 9 g/L NaCl saline, 4 mg/kg FMD, 10 CPA, FMD+10 respectively, daily for d. On d 10, area determined planimetry. The level...