A5100324653- Epilepsy research and treatment
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Genetics and Neurodevelopmental Disorders
- Lung Cancer Treatments and Mutations
- Neuroscience and Neuropharmacology Research
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Digital Marketing and Social Media
- HER2/EGFR in Cancer Research
- Metabolism and Genetic Disorders
- Pancreatic and Hepatic Oncology Research
- Chinese history and philosophy
- Genomics and Rare Diseases
- EEG and Brain-Computer Interfaces
- China's Ethnic Minorities and Relations
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Drug Transport and Resistance Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Glycogen Storage Diseases and Myoclonus
- Family Support in Illness
Peking Union Medical College Hospital
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Peking University First Hospital
2016-2025
Peking University
2016-2025
Southwest Medical University
2012-2025
Air Force Medical University
2012-2025
Zhejiang University
2016-2025
Hangzhou Seventh Peoples Hospital
2022-2025
Shenzhen Luohu People's Hospital
2022-2024
Shanghai Ninth People's Hospital
2021-2024
Summary Objective To evaluate hippocampal volume changes and neuropsychological performances in patients with either amnestic mild cognitive impairment ( aMCI ) or Alzheimer's disease (AD). Methods Thirty‐eight AD dementia, 22 patients, 20 healthy controls were enrolled. Bilateral was measured concurrently mini‐mental state examination (MMSE), auditory verbal learning test (AVLT), Boston naming (BNT), activities of daily living (ADL) test. Baseline two additional follow‐up examinations...
Mutations in SCN8A, a voltage-gated sodium-channel type VIII alpha subunit gene, have recently been recognized as one of the pathogenic mechanisms leading to epilepsy and intellectual/developmental disabilities (IDDs). The aim this study was detect SCN8A mutations Chinese patients with unknown etiology ID/DD.We used targeted next-generation sequencing identify IDDs. A filter process performed prioritize rare variants potential functional significance. Sanger confirmed determined parental...
Atezolizumab intravenous (IV) is approved for the treatment of various solid tumours. To improve convenience and health care efficiencies, a coformulation atezolizumab recombinant human hyaluronidase PH20 was developed subcutaneous (SC) use. Part 2 IMscin001 (NCT03735121) randomised phase III, open-label, multicentre, noninferiority study comparing drug exposure SC with IV.
This study investigated whether programmed death-ligand 1 (PD-L1) expression of circulating tumor cells (CTCs) in peripheral blood can serve as a predictive biomarker for immunotherapy efficacy patients with advanced non-small-cell lung cancer (NSCLC).We employed negative enrichment method to isolate CTCs. We identified PD-L1 + CTCs PD-L1+/4',6-diamidino-2-phenylindole (DAPI)+/CD45-circulating through an immunofluorescence method. Tumor tissue was determined by immunohistochemical staining....
The distal-less homeobox gene 4 (DLX4) is a member of the DLX family genes. Although absent from most normal adult tissues, DLX4 widely expressed in leukemia, lung, breast, ovarian and prostate cancers. However molecular targets, mechanisms pathways that mediate role tumor metastasis are poorly understood. In this study, we found induces cancer cells to undergo epithelial mesenchymal transition (EMT) through TWIST. Overexpression increased expression TWIST cell lines, resulting migratory...
Purpose Immune checkpoint inhibitors (ICIs) have recently emerged as an important option for treating patients with advanced non-small cell lung cancer (NSCLC). Neoantigens are biomarkers and potential immunotherapy targets that play roles in the prognosis treatment of NSCLC. This study aimed to evaluate characterize relationships between somatic mutations neoantigens specimens from who underwent surgical Patients Methods prospective evaluated NSCLC at Peking Union Medical College, China,...
We have developed a TPGS–GA conjugate and TPGS–LA which possess more effective P-gp inhibition compared to TPGS because of the enhancement hydrophilicity negative charge.
ABSTRACT Kaposi's sarcoma is one of the most common malignancies in HIV-infected individuals. The responsible agent, sarcoma-associated herpesvirus (KSHV; HHV8), expresses multiple microRNAs (miRNAs), but targets and functions these miRNAs are not completely understood. After infection primary endothelial cells with KSHV, growth arrest DNA damage-inducible gene 45 beta ( GADD45B ) repressed genes using genomic expression profiling. was also mRNA profiling experiments when KSHV were...
Abstract Background Immune checkpoint inhibitors (ICIs) are the standard treatment for advanced lung cancer, but immune‐related adverse events (irAEs) remain poorly understood, especially in a real‐world setting. Methods A multicenter observational study was conducted. Medical records of cancer patients treated with ICIs at 26 hospitals from January 1, 2015, to February 28, 2021, were retrieved. Types included antiprogrammed cell death 1 or ligand (PD‐L1) monotherapy, anticytotoxic...
Peripheral blood-based biomarkers (PBB) predicting response, survival and immune-related adverse events (irAEs) in patients with advanced non-small cell lung cancer (NSCLC) treated immune checkpoint inhibitors (ICIs) are still a matter of debate. Thus, we investigated the associations between PBB, efficacy ICIs incidence irAEs.Patients NSCLC, who had been at Peking Union Medical College Hospital received or chemoimmunotherapy from January 2015 to December 2020, were retrospectively...
Purpose: We aimed to understand the current situation of smartphone addiction in pregnant women, and explored moderating effect self-efficacy between pregnancy stress addiction. Patients Methods: This study adopted a longitudinal design collect women from obstetrics gynecology department tertiary hospital Shenyang 2020 early (T1) their late (T2). A total 342 questionnaires were collected, including Smartphone Addiction Scale-Short Version (SAS-SV), Pregnancy Pressure Scale (PPS), Chinese...
BACKGROUND Phelan-McDermid syndrome (PMS) is a rare genetic disorder characterized by intellectual disability, delayed language development, autism spectrum disorders, motor tone abnormalities, and high risk of psychiatric symptoms, including bipolar disorder. CASE SUMMARY This report presented an 18-year clinical history 36-year-old woman with PMS, marked disabilities, social withdrawal, stereotyped behaviors. Diagnosed at the age 18 years old, she encountered significant treatment...
Breast cancer (BC) is the most frequently diagnosed and leading cause of cancer-related deaths among women worldwide. It crucial to develop a cost-effective BC genetic panel for detection diagnosis. In this study, tissue samples from 52 patients peripheral blood 18 healthy volunteers were collected in western China, followed by gDNA extraction. H&E IHC analysis employed detect expression invasive tissues. We analyzed data using public databases such as COSMIC/ClinVar/HGMD along with our own...
ABSTRACT IMscin001 is a two‐part dose‐finding (Phase Ib) and ‐confirmation III) study to evaluate atezolizumab pharmacokinetics of subcutaneous (SC) compared with intravenous (IV) administration in patients locally advanced or metastatic non‐small cell lung cancer (NSCLC). The objectives the current analyses were characterize population (popPK) determine relationship between exposure safety efficacy endpoints IMscin001. A previously validated IV popPK model was extended add SC absorption...