A5101460562- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Neonatal and fetal brain pathology
- Polysaccharides and Plant Cell Walls
- Spectroscopy Techniques in Biomedical and Chemical Research
- Fetal and Pediatric Neurological Disorders
- Autophagy in Disease and Therapy
- Pharmacological Effects and Toxicity Studies
- Polysaccharides Composition and Applications
- RNA regulation and disease
- Diet and metabolism studies
- Advanced Cellulose Research Studies
- RNA and protein synthesis mechanisms
- Endoplasmic Reticulum Stress and Disease
Peking University First Hospital
2023-2025
Peking University
2023-2025
Shandong Agricultural University
2023
Second Affiliated Hospital of Nanjing Medical University
2017-2021
Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is a new and rare histopathological entity developmental malformations. The clinical characteristics MOGHE remain challenging.Children histologically confirmed were retrospectively studied. findings, electroclinical imaging features, postoperative outcomes analyzed, previously published studies reviewed up to June 2022.Thirty-seven children included our cohort. Clinical early onset infancy (94.6%...
Abstract Objective To provide evidence for choosing surgical or nonsurgical treatment epilepsy in patients with unilateral multilobar and hemispheric polymicrogyria (PMG). Methods We searched published studies until September 2022 related to PMG included who were followed up at the Pediatric Epilepsy Centre of Peking University First Hospital past 10 years. summarized clinical characteristics compared long‐term outcomes after (anti‐seizure medications, ASMs) treatment. Results A total 70 (49...
Status epilepticus (SE) is defined as continuous seizure activity lasting more than 5 minutes. It results in neuronal cell death, mediated by endoplasmic reticulum (ER) stress response. Previously, metformin demonstrated neuroprotective effects primary cortical neurons. In this study, we analyzed the effect of on ER via pro-apoptotic protein kinase RNA-like (PERK)-eukaryotic initiation factor 2α (eIF2α)-C/EBP homologous (CHOP) pathway. SE was induced rats pentylenetetrazole. Following SE,...
Full-disk spectroscopic observations of the solar corona are highly desired to forecast eruptions and their impact on planets uncover origin wind. In this paper, we introduce a new multi-slit design (5 slits) obtain extreme ultraviolet (EUV) spectra simultaneously. The selected spectrometer wavelength range (184-197 \r{A}) contains several bright EUV lines that can be used for spectral diagnostics. approach offers an unprecedented way efficiently global data but ambiguity from different...
Objective: The genetic aetiology of epileptic encephalopathy (EE) is growing rapidly based on next generation sequencing (NGS) results. In this single-centre study, we aimed to investigate a cohort Chinese children with early infantile (EIEE). Methods: NGS was performed 50 unexplained EIEE. clinical profiles pathogenic variants were characterised and analysed in detail. Conservation analysis homology modelling predict the impact STXBP1 variant protein structure. Results: Pathogenic...
Mutations in PCDH19 are associated with epilepsy, intellectual disability and behavioral disturbances, mostly related to females. The unique X-linked pattern of inheritance affects females predominantly, while usually is transmitted through asymptomatic males. Recently, new research has demonstrated that males a mosaic could also be affected. As yet, mutations have been reported hundreds females; however, only 15 were exhibit epileptic seizures the onset ranges between 6 31 months. These...