A5054888797- Genetic diversity and population structure
- Epigenetics and DNA Methylation
- Nigella sativa pharmacological applications
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Retinal Development and Disorders
- RNA modifications and cancer
- Bioactive Compounds and Antitumor Agents
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Cancer Cells and Metastasis
- Genomics and Phylogenetic Studies
- Cancer Research and Treatments
- Molecular Biology Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Forensic and Genetic Research
- Natural product bioactivities and synthesis
- Cancer-related Molecular Pathways
- Identification and Quantification in Food
- COVID-19 Clinical Research Studies
Southwest Medical University
2016-2025
Chiang Mai University
2021-2025
Macau University of Science and Technology
2015-2025
Affiliated Hospital of Southwest Medical University
2018-2024
Central South University
2002-2024
West China Hospital of Sichuan University
2024
Sichuan University
2024
First Affiliated Hospital of Sichuan Medical University
2012-2023
Nanjing Medical University
2021
Shanghai Sixth People's Hospital
2021
The ACE2 gene is a receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) for COVID-19 (coronavirus disease 2019). To analyze the expression profiles and clinical significances this in humans, RNA-seq data representing 27 different tissues were analyzed using NCBI; total RNA was extracted from mouse semi-quantitative reverse transcriptional-polymerase chain reaction (Q-RT-PCR) carried out. Immunohistochemistry normal cancer TCGA survival analysis renal liver conducted....
Twist1, a basic helix-loop-helix transcription factor, promotes breast tumor cell epithelial-mesenchymal transition (EMT), invasiveness, and metastasis. However, the mechanisms responsible for regulating Twist1 stability are unknown in these cells. We identified serine 68 (Ser 68) as major phosphorylation site of by mass spectrometry with specific antibodies. This Ser is phosphorylated p38, c-Jun N-terminal kinases (JNK), extracellular signal-regulated kinases1/2 vitro, its levels positively...
Growing evidence suggests that miR-29a has an important role in regulating tumourigenesis and development of various types cancer. However, the underlying mechanism colorectal cancer (CRC) remain largely unknown.MiR-29a targeted gene was identified by luciferase assay western blot. MiR-29a function analysed invasion assays orthotopic transplantation mouse model. The pathway assayed real-time PCR, blot chip analysis.KLF4 as a direct target miR-29a. promoted CRC cell invasion, which blocked...
Abstract: Baicalin is one of the main bioactive flavone glucuronides derived as a medicinal herb from dried roots Scutellaria baicalensis Georgi, and it widely used for treatment fever, inflammation, other conditions. Due to baicalin's poor solubility in water, its absolute bioavailability after oral administration only 2.2%. The objective this study was develop novel baicalin-loaded nanoemulsion improve baicalin. Based on result pseudoternary phase diagram, formulation consisting...
Proteins that promote epithelial to mesenchymal transition (EMT) are associated with cancer metastasis. Inhibition of EMT regulators may be a promising approach in therapy. In this study, Thymoquinone (TQ) was used treat cell lines investigate its effects on EMT-regulatory proteins and We show TQ inhibited growth, migration invasion dose-dependent manner. At the molecular level, treatment decreased transcriptional activity TWIST1 promoter mRNA expression TWIST1, an EMT-promoting...
MicroRNA-34a (miR-34a) plays an essential role against tumorigenesis and progression of cancer metastasis. Here, we analyzed the expression, targets functional effects miR-34a on epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs), such as TWIST1, SLUG ZEB1/2, EMT-inducing protein NOTCH1 in breast (BC) cell migration invasion its correlation with clinical outcomes. Expression is downregulated human metastatic cancers (MBC) compared normal tissues negatively...
Estimating the post mortem interval (PMI) is a crucial and contentious issue in forensic research, particularly criminal cases. Traditional methods for PMI estimation are limited by constraints inaccuracies. Circular RNA (circRNA), formed through exon or intron looping to create complete circular structure without 5′ end cap 3′ poly(A) tail, exhibits exceptional stability, abundance, tissue-specific characteristics that make it potentially valuable estimation. However, research on...
Proteasome activity is frequently enhanced in cancer to accelerate metastasis and tumorigenesis. REGγ, a proteasome activator known promote p53/p21/p16 degradation, often overexpressed cells. Here we show that p53/TGF-β signalling inhibits the REGγ–20S pathway by repressing REGγ expression. Smad3 p53 interact on promoter via p53RE/SBE region. Conversely, mutant binds recruits p300. Importantly, prevents Smad3/N-CoR complex formation promoter, which enhances of contributes gain function....
Here we report that mice deficient for the proteasome activator, REGγ, exhibit a marked resistance to TPA (12-O-tetradecanoyl-phorbol-13-acetate)-induced keratinocyte proliferation, epidermal hyperplasia and onset of papillomas compared with wild-type counterparts. Interestingly, massive increase REGγ in skin tissues or cells resulting from induces activation p38 mitogen-activated protein kinase (MAPK/p38). Blocking MAPK prevents elevation HaCaT treatment. AP-1, downstream effector MAPK/p38,...
Abstract TRIM28 regulates its target genes at both transcriptional and posttranscriptional levels. Here we report that a TRIM28-TWIST1-EMT axis exists in breast cancer cells promotes metastasis by stabilizing TWIST1 subsequently enhancing EMT. We find is highly expressed cell lines advanced tissues the levels of are positively correlated with aggressiveness carcinomas. Overexpression depletion up- down-regulates protein, but not mRNA TWIST1, respectively, suggesting upregulates...
Cervical cancer is one of the most common gynecological malignant tumors worldwide, for which chemotherapeutic strategies are limited due to their non-specific cytotoxicity and drug resistance. The natural product thymoquinone (TQ) has been reported target a vast number signaling pathways in carcinogenesis different cancers, hence regarded as promising anticancer molecule. Inhibition epithelial mesenchymal transition (EMT) regulators an important approach research. In this study, TQ was used...