A5030002021- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Genetic diversity and population structure
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Sirtuins and Resveratrol in Medicine
- Nigella sativa pharmacological applications
- Trace Elements in Health
- MicroRNA in disease regulation
- Advanced Photocatalysis Techniques
- Circular RNAs in diseases
- Bioactive Compounds and Antitumor Agents
- Luminescence Properties of Advanced Materials
- interferon and immune responses
- Neurosurgical Procedures and Complications
- Molecular Biology Techniques and Applications
- Trigeminal Neuralgia and Treatments
Shanghai Jiao Tong University
2015-2025
Suzhou Kowloon Hospital
2013-2025
Central South University
2015-2024
Peking University
2023
National Yang Ming Chiao Tung University
2020
Kowloon Hospital
2017-2018
Changsha University
2018
Creative Commons
2017
National Chung Hsing University
2014
Jiangxi Fisheries Research Institute
2012
The ACE2 gene is a receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) for COVID-19 (coronavirus disease 2019). To analyze the expression profiles and clinical significances this in humans, RNA-seq data representing 27 different tissues were analyzed using NCBI; total RNA was extracted from mouse semi-quantitative reverse transcriptional-polymerase chain reaction (Q-RT-PCR) carried out. Immunohistochemistry normal cancer TCGA survival analysis renal liver conducted....
Although oxidation is the most common biological and energy producing reaction, oxidative stress harmful to cell, because products of such as free radicals peroxides damage cellular components, causing several diseases. Damage in DNA responsible for cancer formation progression. However, enzymes superoxide dismutase, catalase, glutathione peroxidase, reductase, S-transferase etc. act antioxidants influence stress. Polymorphisms these are supposed be associated with subsequently individual's...
Abstract TRIM28 regulates its target genes at both transcriptional and posttranscriptional levels. Here we report that a TRIM28-TWIST1-EMT axis exists in breast cancer cells promotes metastasis by stabilizing TWIST1 subsequently enhancing EMT. We find is highly expressed cell lines advanced tissues the levels of are positively correlated with aggressiveness carcinomas. Overexpression depletion up- down-regulates protein, but not mRNA TWIST1, respectively, suggesting upregulates...
Cervical cancer is one of the most common gynecological malignant tumors worldwide, for which chemotherapeutic strategies are limited due to their non-specific cytotoxicity and drug resistance. The natural product thymoquinone (TQ) has been reported target a vast number signaling pathways in carcinogenesis different cancers, hence regarded as promising anticancer molecule. Inhibition epithelial mesenchymal transition (EMT) regulators an important approach research. In this study, TQ was used...
CTSL is expressed by cancerous tissues and encodes a lysosomal cysteine proteinase that regulates cancer progression SARS-CoV-2 entry.Therefore, it critical to predict the susceptibility of patients for evaluate correlation between disease outcomes expression in malignant tissues.In current study, we analyzed expression, mutation rate, survival COVID-19 normal tissues, using online databases.We also performed immunohistochemistry (IHC) test western blot monitor its regulation cordycepin...
Recently, microRNAs (miRNAs), a kind of small and non-coding RNA, can target the downstream molecules. Increasing evidence demonstrates that miRNAs meditate onset progression variety tumors. In present study, we carried out gene transfection, western blot, reverse transcription PCR (RT-PCR) to explore role miR-22 in glioblastoma tissues cell lines. Here, verified expression was downregulated cells rather than matched non-tumor normal human astrocyte (NHA) (p < 0.001). By contrast, SIRT1...
Hepatic copper determination is an important test for the diagnosis of Wilson's disease (WD). However, method has not been standardized, diagnostic accuracy evaluated prospectively, and optimal cut‐off value remains controversial. Accordingly, we aimed to prospectively evaluate hepatic content, as determined using entire core a liver biopsy sample. Patients whom was indicated were consecutively enrolled. content with atomic absorption spectroscopy. All assays performed careful quality...
Cervical cancer is one of the most common causes cancer-related mortality in women developing countries. Interferon (IFN)-α has been widely used treatment various types cancer, including cervical and IFN-stimulated gene 15 (ISG15), an ubiquitin-like protein, upregulated by IFN-α treatment. The anti-virus antitumor effects ISG15 have reported; however, its mechanism action not yet fully elucidated. In this study, HeLa cells were as a model system to investigate roles IFN-α-mediated cell...
Ochratoxin A (OTA) is one of the most common mycotoxins contaminating feed and foodstuffs. Therefore, a great deal concern associated with AFB1 toxicity. In this work, fast sensitive fluorescence aptamer biosensor has been proposed for OTA assay. absence OTA, can form G-quadruplex structure thioflavin T (ThT) dye, which results in increased fluorescence. After joining combines be formed. Only faint was finally observed when ThT weakly reacts quadruplex. Through test method, entire reaction...
// Saber Imani 1,2,3,* , Jingliang Cheng 2,* Marzieh Dehghan Shasaltaneh 4,5,* Chunli Wei 2,6 Lisha Yang 2 Shangyi Fu 7,8 Hui Zou 1,2 Md. Asaduzzaman Khan Xianqin Zhang Hanchun Chen 9 Dianzheng 10 Chengxia Duan 11 Hongbin Lv Yumei Li 8 Rui and Junjiang 1,2,6 1 Hunan Normal University Medical College, Changsha, Hunan, China Key Laboratory of Epigenetics Oncology, Research Center for Preclinical Medicine, Southwest University, Luzhou, Sichuan, 3 Chemical Injuries Center, Baqiyatallah Sciences...
Furin is a proprotein convertase that activates different kinds of regulatory proteins, including SARS-CoV-2 spike protein which contains an additional furin-specific cleavage site.It essential in predicting cancer patients' susceptibility to and the disease outcomes due varying furin expressions tumor tissues.In this study, we analyzed furin's expression, methylation, mutation rate, functional enrichment, survival rate COVID-19 normal tissues using online databases, our IHC.As result,...
The worldwide COVID‑19 pandemic was brought on by a new coronavirus (SARS Cov‑2). A marker/receptor called Dipeptidyl peptidase 4/CD26(DPP4/CD26) may be crucial in determining susceptibility to tumors and coronaviruses. However, the regulation of DPP4 COVID‑invaded cancer patients its role small molecule compounds remain unclear. present study used Human Protein Atlas, Monaco, Schmiedel databases analyze expression human tissues immune cells. association between survival various tumor...
The genetic polymorphisms of biotransformation phase I enzymes, cytochrome P450 (CYP1A1 and CYP2D6), II glutathione S-transferase (GSTM1 GSTT1), were analyzed in 204 healthy persons 348 leukemia patients, who suffered from also acute lymphoblastic (ALL), nonlymphoblastic (ANLL) chronic myelogenous (CML), the Han ethnic group Changsha City Hunan Province China. Our results showed that frequencies CYP1A1, CYP2D6 GSTT1 among groups including leukemia, ANLL, control have no significant...
The Cordyceps mushrooms have a long history as medicinal fungi.In Traditional Chinese Medicine, been used to treat several conditions including cancers for thousand of years.Extracts from both mycelium and fruiting bodies C. sinensis, militaris other species showed significant anticancer activities by various mechanisms such as, modulating immune system inducing cell apoptosis.Some polysaccharide components cordycepin (3'-deoxyadenosine) isolated sinensis militaris, which acted potent...