A5041616363- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Neonatal Health and Biochemistry
- Microbial Inactivation Methods
- Genomics and Rare Diseases
- Amino Acid Enzymes and Metabolism
- Thyroid Disorders and Treatments
- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Biochemical and Molecular Research
- Congenital heart defects research
- Phytochemicals and Antioxidant Activities
- Probiotics and Fermented Foods
- Microbial Applications in Construction Materials
- Enzyme Production and Characterization
- Reproductive Health and Technologies
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Proteins in Food Systems
- Food Industry and Aquatic Biology
- Phytochemistry and Bioactivity Studies
- Neonatal and Maternal Infections
- Enzyme function and inhibition
Jinan Maternity And Care Hospital
2014-2025
Shandong Agricultural University
2020-2025
Hunan Normal University
2017-2025
Yantaishan Hospital
2025
Zhongkai University of Agriculture and Engineering
2025
Zhongshan Hospital
2024
Guangzhou University
2024
China Three Gorges University
2024
Pulmonary Associates
2024
Shandong Maternal and Child Health Hospital
2004-2023
Newborn screening via biochemical tests is in use worldwide. The availability of genetic sequencing has allowed rapid for a substantial number monogenic disorders. However, the outcomes this strategy have not been evaluated general newborn population.To evaluate applying gene panel as first-tier test.This cohort study included newborns who were prospectively recruited from 8 centers China between February 21 and December 31, 2021. Neonates with positive results followed up before July 5,...
This novel study identifies the effective anti-inflammatory phenolic compounds in dandelion and provides mechanistic insights into their interactions with receptor proteins (toll‐like 4, TLR4; co‐receptor myeloid differentiation protein-2, MD-2) using UHPLC-ESI-MS/MS, lipopolysaccharide (LPS)-stimulated THP-1 cell line, fluorescence quenching anisotropy, molecular docking (single ligand multi-ligand docking) dynamics simulation. A 50 % aqueous methanol extract had a greater effect higher...
// Saber Imani 1,2,3,* , Jingliang Cheng 2,* Marzieh Dehghan Shasaltaneh 4,5,* Chunli Wei 2,6 Lisha Yang 2 Shangyi Fu 7,8 Hui Zou 1,2 Md. Asaduzzaman Khan Xianqin Zhang Hanchun Chen 9 Dianzheng 10 Chengxia Duan 11 Hongbin Lv Yumei Li 8 Rui and Junjiang 1,2,6 1 Hunan Normal University Medical College, Changsha, Hunan, China Key Laboratory of Epigenetics Oncology, Research Center for Preclinical Medicine, Southwest University, Luzhou, Sichuan, 3 Chemical Injuries Center, Baqiyatallah Sciences...
Summary Background Phenylketonuria (PKU) is a rare inborn disease, which, untreated, leading to severe neurobehavioral dysfunction. Considering its complexity, the management of PKU may bring formidable economic burden parents and caregivers. It still unknown what out‐of‐pocket expenses are for patient with in China. This paper explores household financial classical impact on Chinese families quantitative manner first time. Methods A non‐interventional observational study was conducted at...
Objective: The cblC type of combined methylmalonic acidemia and homocystinuria, an inherited disorder with variable phenotypes, is included in newborn screening (NBS) programs at multiple centers China. present study aimed to investigate the long-term clinical benefits individual. Methods: A national, retrospective multi-center infants confirmed defect identified by NBS between 2004 2020 was conducted. We collected a large cohort 538 patients investigated their data detail, including disease...
Zhushao Granules (ZSG) had exhibited beneficial effects in the treatment of ulcerative colitis (UC) as an effective herbal prescription Traditional Chinese Medicine. However, underlying anti-inflammatory mechanism ZSG remains unclear. This study aimed to decipher against UC combining network pharmacology and animal-based experiments. Network was employed identify active components therapeutic targets UC. The protein–protein interaction (PPI) constructed among using STRING database, GO...
Soybean (Glycine max (L.) Merr.) is a significant economic oilseed crop, and saline-alkali soils restrict soybean yield. Identifying salt-tolerant genes key strategy for enhancing productivity under conditions. The roles of the GmABCB gene family in growth, development, stress resistance remain incompletely understood. Bioinformatics approaches were employed to identify analyze genes. A total 39 identified analyzed genome, focusing on their phylogenetic relationships, chromosomal...
Dual oxidases (DUOXs) are essential for thyroid hormone synthesis. Rare DUOX variations have been detected in patients with congenital hypothyroidism (CH); however, their mode of inheritance and genotype-phenotype correlations remain unclear. Additionally, no study has determined whether common variants confer a risk CH. To elucidate the molecular clinical characteristics CH caused by rare variants. Targeted next-generation sequencing was performed on 203 trios (parents child CH) to screen...
Bacillus thuringiensis(Bt) bio-pesticides is a kind of selective and efficient pesticides, but the high cost raw materials always limits its development, food waste contains superior nutritional elements which could sustain growth most microorganisms. So we choose as material, explored feasibility producing optimized influence parameters during fermentation process. In this work, with 75% water content presented δ-endotoxin efficiency 862 μg/mL, spore count 2.23×1011 CFU/mL entomotoxicity...
Objective This study was performed to evaluate the diagnostic value of neutrophil CD64 index in patients with sepsis intensive care unit (ICU). Methods Patients who were treated at ICU authors’ institution from December 2016 June 2018 retrospectively reviewed. The controls comprised age- and sex-matched underwent coronary bypass had no evidence infection. index, C-reactive protein (CRP) level, procalcitonin level compared between two groups. performance these measures, including sensitivity,...