A5086781197- Inflammatory Bowel Disease
- Microscopic Colitis
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders
- Autoimmune and Inflammatory Disorders Research
- Clostridium difficile and Clostridium perfringens research
- Cancer Genomics and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
- Gastrointestinal disorders and treatments
- Animal Disease Management and Epidemiology
- Biomedical Research and Pathophysiology
- Genetic and Kidney Cyst Diseases
- Adenosine and Purinergic Signaling
- Diverticular Disease and Complications
- Pregnancy and Medication Impact
- Health and Well-being Studies
- Gut microbiota and health
- Hidradenitis Suppurativa and Treatments
- Immune Cell Function and Interaction
- Hair Growth and Disorders
- Adrenal and Paraganglionic Tumors
- Biosimilars and Bioanalytical Methods
Peking Union Medical College Hospital
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Weatherford College
2021
Capital Medical University
2021
Chongqing Medical University
2020
Wenzhou Medical University
2020
China Agricultural University
2018
Xiangya Hospital Central South University
2016
Central South University
2016
Center for Disease Control
2015
Modulation of KRAS activity by upstream signals has revealed a promising new approach for pancreatic cancer therapy; however, it is not clear whether microRNA-associated axis involved in the carcinogenesis cancer. Here, we identified miR-193b as tumor-suppressive miRNA ductal adenocarcinoma (PDAC). Expression analyses that was downregulated (10/11) PDAC specimens and cell lines. Moreover, found functioned cell-cycle brake cells inducing G1-phase arrest reducing fraction S phase, thereby...
The insecticide fipronil can be metabolized to its sulfone in mammalian species. Two camel single-domain antibodies (VHHs) F1 and F6, selective fipronil-sulfone, respectively, were generated used develop enzyme linked immunosorbent assays (ELISAs) for the detection of two compounds sera black-tailed prairie dogs rats. limits fipronil-sulfone rodent by corresponding ELISAs 10 30 ng mL–1, linear ranges 30–1000 75–2200 mL–1. showed a good recovery cospiked control (90–109%) rats (93–106%)....
Purpose Immune checkpoint inhibitors (ICIs) have recently emerged as an important option for treating patients with advanced non-small cell lung cancer (NSCLC). Neoantigens are biomarkers and potential immunotherapy targets that play roles in the prognosis treatment of NSCLC. This study aimed to evaluate characterize relationships between somatic mutations neoantigens specimens from who underwent surgical Patients Methods prospective evaluated NSCLC at Peking Union Medical College, China,...
Background: Crohn disease is a chronic granulomatous inflammatory of gastrointestinal tract. Previous studies showed strictures overexpress fibroblast activation protein and had active 68 Ga-FAPI-04 uptake. Our study was to compare the diagnostic performance 18 F-FDG PET/CT in disease. Patients Methods: This prospective cohort recruiting patients with newly diagnosed or relapsed All underwent PET/CT. The 2 modalities their uptake values were compared. correlation PET semiquantitative...
Digestive system neuroendocrine carcinomas (NECs) are rare neoplasms originating from cells with a poor prognosis and limited effective treatments. Programmed cell death protein 1/ligand 1 (PD-1/PD-L1) blockade has been used in the management of more than 10 solid tumors achieved promising clinical outcomes. PD-L1 expression, immune infiltration, tumor mutational burden (TMB), microsatellite instability (MSI) all verified biomarkers that can predict response to anti-PD-1/PD-L1 therapy. Here,...
The increase in the detection rate of synchronous multiple primary lung cancer (MPLC) has posed remarkable clinical challenges due to limited understanding its pathogenesis and molecular features. Here, comprehensive comparisons genomic immunologic features between MPLC solitary nodule (SN), as well different lesions same patient, were performed. Compared with SN, displayed a lower EGFR mutation but higher rates BRAF, MAP2K1, MTOR mutation, which function exactly upstream downstream...
Clostridium difficile infection (CDI) incidence and risk factors in patients with inflammatory bowel disease (IBD) have been extensively studied. However, data describing CDI Chinese IBD are limited. We investigated the cumulative incidence, factors, outcomes of patients. conducted a retrospective, case–control study hospitalized at Peking Union Medical College Hospital from January 2010 to December 2015. was diagnosed based on presence active symptoms positive enzyme immunoassay-based stool...
In order to study the CXCR4 expression with [68Ga]pentixafor PET in different types of non-Hodgkin lymphoma, we performed a retrospective describe PET/CT imaging spectrum lymphomas and compare it [18F]FDG PET/CT.Twenty-seven patients newly diagnosed lymphoma were recruited retrospectively. showed increased radioactivity lymphoplasmacytic (n = 8), marginal zone 4), diffuse large B cell 3), follicular 2), mantle 1), unclassified indolent enteropathy associated T 3). However, peripheral not...
Objectives: Clinical and epidemiological evidence suggests that cocaine use is associated with an increased risk of premature atherosclerosis. The objectives this study were to explore (1) whether abstinence a reduced marker endothelial dysfunction, (2) slower coronary plaque progression, (3) reduction in dysfunction African American chronic users contrast-enhanced CT angiography-confirmed less than 50% stenosis. Methods: Between March June 2014, total 57 stenosis Baltimore, Maryland,...
Prevalence of inflammatory bowel disease (IBD) is increasing in China. The EXPLORE study evaluated the incidence and indicators suboptimal responses to first-line anti-tumor necrosis factor (TNF) patients with ulcerative colitis (UC) or Crohn's (CD). We present results for mainland China subgroup.A retrospective chart review was performed adults IBD at 10 centers who initiated anti-TNF therapy between 01 March 2010 2015. cumulative response assessed over 24 months using Kaplan-Meier method....
The distinction between intestinal Behηet's disease (BD) and Crohn's (CD) is always challenging due to many overlapping clinical features. We conducted a retrospective study reveal valuable strategies for the differential diagnosis BD CD in Chinese patients based on their colonoscopic features.Thirty-five 106 hospitalized from January 1983 2010, who had ulcerative lesions terminal ileum or colon under colonoscopy no history of gastrointestinal operation except appendectomy before admission,...
Persistent disease activity is associated with a poor prognosis in patients inflammatory bowel (IBD). This study aims to explore the accuracy of highly sensitive C-reactive protein/albumin ratio (CAR) determining IBD activity.The clinical data 231 treated at Peking Union Medical College Hospital from 2012 2018 were analyzed retrospectively. The classified as having active or remission according Crohn index scores for (CD) and partial Mayo ulcerative colitis (UC).This included (137 CD 94 UC)....
Many reports have documented the increasing impact of Clostridium difficile infection (CDI) in patients with ulcerative colitis (UC). We conducted a retrospective study to determine incidence, clinical characteristics, risk factors and prognosis CDI UC. studied UC, hospitalized between January 2010 December 2015 tertiary hospital China. Stool samples were tested for C. toxins A B (CDAB) by enzyme immunoassays UC disease flare. was diagnosed symptoms positive CDAB test, each case matched...
Purpose: Biologic agent-induced cardiotoxicity is markedly concerning. Rheumatoid arthritis (RA) treated with biologic agents known to have the potential for cardiotoxicity; however, existing clinical evidence not adequate explain real-world patterns of cardiotoxicity. In this study, we quantify risk in patients rheumatoid biological agents. Methods: Cardiotoxicity reports induced by four types agents, abatacept, adalimumab, tocilizumab, and etanercept were used mine data from FDA's adverse...
Clarifying the risk factors for postoperative complications and taking measures to minimize these will improve outcomes in patients with ulcerative colitis (UC). This study aimed systemically explore short-term Chinese UC undergoing ileocolorectal surgery.Forty-nine proctocolectomy or ileostomy were retrospectively enrolled. Univariate multivariate logistic regression analyses conducted reveal among clinical, laboratory, surgical variables as well preoperative medications.Twenty-two (44.9%)...
Abstract Context Cushing syndrome is rarely caused by the secretion of cortisol from ovarian tumors. In clinical decision-making, it important to determine whether tumor capable secreting cortisol. Selective and adrenal venous sampling scarcely reported in localization ACTH-independent ectopic syndrome. Case Description We present a case 40-year-old Chinese woman who had weight gain, hirsutism, hypertension, menstrual disorder over 6 months. Her physical examination biochemical assessment...
To the Editor: Cronkhite-Canada syndrome (CCS) is a rare, non-hereditary disease characterized by diffuse gastrointestinal polyposis and ectodermal abnormalities.[1] Although CCS polyps are not considered to be neoplastic, 15% 25% patients have been documented with colorectal or gastric cancer at diagnosis, up 40% of adenomas adenomatous changes.[2] Extra-gastrointestinal neoplasms sporadically reported, but their association remains under investigation. The underlying mechanism has less...
Abstract Background Systemic juvenile idiopathic arthritis (sJIA) has many clinical features overlapping with familial Mediterranean fever (FMF), which is caused by mutations in MEFV gene. And FMF patients were easily misdiagnosed as sJIA China. So we speculate that critical genetic background for and influences patients’ severity. In this study, aim to figure out whether are risk factor the occurrence of study association disease severity patients. Methods The present includes 57 children...
Eltrombopag is an orally bioavailable drug developed as a second-line treatment for immune thrombocytopenia. However, there are limited reports on thrombotic events related to eltrombopag use. This study aimed assess the relationship between and in large population extracted from Food Drug Administration Adverse Event Reporting System (FAERS) database.A total of 525 FAERS associated with alone 59 those simultaneous use glucocorticoids, Q1 2004 Q3 2021, were included. Reports analysed using...
To define endoscopic and histological remission in ulcerative colitis (UC) accurately, several scoring systems have been established. A novel virtual electronic chromoendoscopy score, the Paddington International Virtual ChromoendoScopy ScOre (PICaSSO), was developed, validated, reproduced to assess inflammation grade predict patient prognosis. We externally verified validated clinical value of PICaSSO UC patients.This prospective study enrolled 63 patients. The Mayo score (MES), Endoscopic...
The pancreatic β cells can synthesize dopamine by taking L-dihydroxyphenylalanine, but whether acinar has not been confirmed. By means of immunofluorescence, the tyrosine hydroxylase -immunoreactivity and aromatic amino acid decarboxylase (AADC)- immunoreactivity were respectively observed in islet cells. Treatment with tyrosine, caused production incubation INS-1 (rat cell line) primary isolated islets, which was blocked AADC inhibitor NSD-1015. However, only dopamine, detected when AR42J...
OBJECTIVE The aim of this study was to explore the long‐term risk infection in patients with Crohn's disease (CD) on infliximab (IFX) therapy. METHODS All CD treated IFX were recruited from January 2008 December 2015. Their characteristics and infectious events during therapy prospectively collected, evaluated using Cox regression. RESULTS Seventy receiving consecutively recruited. During a median 15 months, experienced 17 which occurred within 21 weeks after initiation Of events, eight...
The predecessor of China Optics was and Applied Digest, which founded in 1985. At that time, it the only retrieval journal field optics China. end 2008, Digest renamed