Abstract Background Falls are an important cause of injury and death older people. Hence, analyzing the multifactorial risk falls from past cases to develop intervention programs is clinically significant. However, due small sample size, there few studies on fall analysis clinical characteristics fallers, especially among hospitalized patients. Methods We collected data 153 inpatients who fell (age ≥ 60 years) hospital nursing adverse event reporting system during hospitalization at Shandong...

Abstract Background Frailty is an expression of vulnerability and decline physical, mental, social activities, more commonly found in older adults. It also closely related to the occurrence poor prognosis coronary artery disease (CAD). Little investigation has been conducted on prevalence determinants frailty adult patients with chronic syndrome (CCS). Methods A cross-sectional study was conducted, simple random sampling used this study. 218 adults (age ≥ 60 years) CCS inpatient admission...

The distinction between intestinal Behηet's disease (BD) and Crohn's (CD) is always challenging due to many overlapping clinical features. We conducted a retrospective study reveal valuable strategies for the differential diagnosis BD CD in Chinese patients based on their colonoscopic features.Thirty-five 106 hospitalized from January 1983 2010, who had ulcerative lesions terminal ileum or colon under colonoscopy no history of gastrointestinal operation except appendectomy before admission,...

Currently, there are few such studies about establishing the frailty prediction model on basis of research factors influencing in older patients, which can better predict and identify its risk factors, then guide formulation intervention measures precisely, especially hospital setting China. Meanwhile, comprehensive geriatric assessment (CGA) provide measurable substantial health improvements for frail people. The study aimed to develop a nomogram among hospitalised people using CGA data...

Clarifying the risk factors for postoperative complications and taking measures to minimize these will improve outcomes in patients with ulcerative colitis (UC). This study aimed systemically explore short-term Chinese UC undergoing ileocolorectal surgery.Forty-nine proctocolectomy or ileostomy were retrospectively enrolled. Univariate multivariate logistic regression analyses conducted reveal among clinical, laboratory, surgical variables as well preoperative medications.Twenty-two (44.9%)...

Abstract Background Matrix Gla protein (MGP) is a secreted contributed to the immunomodulatory functions of mesenchymal stromal cells. Microarray profiling found significantly higher expression level extracellular matrix gene MGP in patients with ulcerative colitis (UC). However, little known about role UC and its upstream signaling regulation. This study aimed identify regulator mechanism. Methods Colonic mucosa biopsies were obtained from healthy controls. DNA microarray was used explore...

患者女，53岁，因发现"右乳肿块1个月余"就诊。肿物直径约1.3 cm，灰白色，质韧。镜下病变界尚清，2/3的区域为硬化性腺病，另1/3的区域硬化性间质中杂乱分布着小腺管以及鳞状分化细胞巢，鳞化细胞巢多呈实性条索状，部分形成大小不等的角化囊肿；病变细胞形态温和，核分裂象罕见，并见淋巴细胞聚集灶，局灶浸润周围组织。免疫组织化学显示该区域内大部分细胞巢周围缺乏p63、calponin及CD10染色，部分鳞状分化巢CK5/6和p63阳性，诊断为乳腺硬化性腺病基础上的低级别腺鳞癌。.

Objective To evaluate the efficacy and safety of thalidomide (100 to 200mg per day) in treatment adult refractory Crohn's disease (CD). Methods From July 2008 February 2013, 29 CD patients were enrolled 200 mg day)cohort study. The clinical activity was evaluated by simplified index. Patients remission underwent colon endoscope examination, mucosal healing assessed simple endoscopic score for (SES-CD). Adverse reactions (ADR) also observed. Results Among patients, 23 males six...

Objective: To study the clinicopathological features of invasive lobular carcinoma (ILC) breast with extracellular mucin and outcomes patients. Method: Clinicopathological clinical follow-up (39-123 months a median 55 months) seven ILC were obtained. Hematoxylin-and-eosin (H&E) immunohistochemistry (IHC) stained sections reviewed, fluorescence in situ hybridization (FISH) assay was performed for tumors HER2 IHC 2+. Patient prognosis analyzed literatures related to reviewed. Results: All...

Objective To assess the correlation and agreement of mitral valve geometry parameters obtained by real-time three-dimensional transthoracic echocardiography (RT-3D-TTE) transesophageal (RT-3D-TEE). Methods RT-3D-TTE RT-3D-TEE were performed on 29 healthy volunteers under conscious state general anesthesia respectively. The mid-systole analyzed TomTec Imaging Systems. repeatability test RT-3D-TTE was performed. assessed,and then differences between two methods compared. study approved...

Objective Evaluate myocardial strain of uremic patients after arteriovenous fistula (AVF) quantitatively by using 2-Dimensional Speckle Tracking Imaging (2D-STI), observe change contractility left ventricular volume load. Methods Sixty-six from the Nephrology Department Shangxi Dayi Hospital July 2012 to February 2015 were chosen as AVF group, and 30 age gender matched healthy volunteers control group. Longitudinal stain (LS), circumferential (CS) radial (RS) each segment global...

Objective: To investigate the clinicopathological features, diagnosis and differential of breast myofibroblastoma. Methods: The data prognostic information 15 patients with myofibroblastoma diagnosed at Department Pathology First Affiliated Hospital Zhengzhou University, Zhengzhou, China from 2014 to 2022 were collected. Their clinical characteristics, histological subtypes, immunophenotypes molecular characteristics analyzed. Results: There 12 female 3 male patients, ranging in age 18 78...

Objective: To investigate the efficacy of neoadjuvant therapy (NAT) on HER2-positive breast cancer and to analyze their clinicopathological features. Methods: A total 480 cases who received (NAT), diagnosed at Department Pathology Fudan University Shanghai Cancer Center from 2015 2020, were retrospectively identified. Clinicopathological parameters such as age, tumor size, molecular subtype, type targeted therapy, Ki-67 proliferation index, ER HER2 immunohistochemical expression,...

Objective: To identify BRAF V600E mutations in adult Wilms tumor (WT) with overlapping histologic features of metanephric adenoma (MA) and to investigate the clinicopathological WT. Methods: The clinical WT diagnosed at Fudan University Shanghai Cancer Center, Shanghai, China from 2012 2021 were reviewed. HE-stained slides all cases reviewed by 2 expert pathologists. Representative tissues selected for immunohistochemical (IHC) staining gene sequencing. Results: In MA-like areas (cohort Ⅰ,...

Objective To assess the changes of structure and function moderate mitral valvular regurgitation before after percutaneous coronary intervention (PCI) by real-time 3-dimensional transthoracic echocardiography(RT 3D-TTE). Methods Thirty-two patients with acute myocardial infarction(AMI) were enrolled in study, while 30 healthy subjects selected as control group. All accepted RT 3D-TTE, imaging was analyzed offline TomTec 4D MV-Assessment software. The valve parameters measured. AMI...

乳腺不典型妊娠样增生是一种极为少见的乳腺病变，国内外报道甚少，现报道1例。中年女性患者，体检时发现左乳肿块，影像学检查提示左乳占位性病变，伴有不定形钙化BI-RADS 4B级。临床诊断：左乳腺病伴纤维腺瘤，遂行左乳肿块切除。大体检查可见一粗糙颗粒区，光镜下该病变局限于乳腺小叶内，与囊性高分泌性增生合并存在，部分腺上皮细胞核轻度增大，核仁明显，核质比轻度升高，有异型性，可见少量核分裂象，诊断为乳腺不典型妊娠样增生。.

Objective To investigate the diagnostic value of procalcitonin (PCT) and lactate in cerebrospinal fluid (CSF) combined with conventional biomarkers for post-neurosurgical bacterial meningitis (PBM). Methods Clinical data 213 patients admitted Beijing Tiantan Hospital, Capital Medical University from March 2017 to December were retrospectively analyzed, including 85 cases PBM 128 aseptic (PAM). The CSF procalcitonin, other 12 was analyzed by multivariate logistic regression. A...

Objective We performed a retrospective study to determine the epidemiological characteristics of Klebsiella pneumoniae infection after neurosurgery and elucidate risk. Methods Patients who underwent between January 2012 December 2016 were included.Demographic, clinical, laboratory, microbiological data systemically recorded.17 clinical trials 7 laboratory indicators evaluated as risk factors for meningitis. Results Forty-five cases patients led K. analyzed, K.pneumoniae ESBLs...