A5036635136- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Urinary and Genital Oncology Studies
- Gastrointestinal disorders and treatments
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Reproductive Biology and Fertility
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- Cancer Mechanisms and Therapy
- Ovarian function and disorders
- Testicular diseases and treatments
- Extracellular vesicles in disease
- IgG4-Related and Inflammatory Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunodeficiency and Autoimmune Disorders
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Fujian Medical University
2025
Union Hospital
2025
Fudan University
2023-2024
China Three Gorges University
2015-2024
National Clinical Research Center for Digestive Diseases
2023
National Institutes of Health
2019-2021
National Institute of Allergy and Infectious Diseases
2019-2021
Beijing University of Chemical Technology
2016
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has reached 30 %, with an annual increase. incidence NAFLD-induced cirrhosis is rapidly rising and become the leading indicator for transplantation in US. However, there are currently no US Food Drug Administration-approved drugs NAFLD. Increasing evidence underscores close association between NAFLD bile acid metabolism disorder, highlighting feasibility targeting signaling pathway treatment. farnesoid X receptor (FXR)...
Cellular exosomes are involved in many disease processes and have the potential to be used for diagnosis treatment. In this study, we compared characteristics of derived from human ovarian epithelial cells (HOSEPiC) three cancer cell lines (OVCAR3, IGROV1, ES-2) investigate differences between originating normal malignant cells. Two established colloid-chemical methodologies, electron microscopy (EM) dynamic light scattering (DLS), a relatively new method, nanoparticle tracking analysis...
The selection of individualized treatment for recurrent cervical cancer is challenging. This study aimed to investigate the impact various therapies on survival outcomes after recurrence.Eligible patients were diagnosed with between March 2012 and April 2018. Postrecurrence progression-free (PFS) overall (OS) investigated in whole cohort subgroups, categorized by recurrence site prior radiotherapy history, using a multivariate model that incorporated primary tumors, histological pathology,...
Here, we report the case of a 30-year-old male who presented with acute right calf muscle pain. Computed tomography angiography revealed popliteal artery aneurysm in midsection. Popliteal fossa tissue evaluation that was located beneath an anomalous bundle. Thus, patient diagnosed type III entrapment syndrome and treated surgically. The asymptomatic at rest during physical activity 4 months after surgery unobstructed bloodstream artery. should be considered young patients pseudoaneurysms...
BACKGROUND Gastrointestinal submucosal tumors (SMTs) mostly grew in the lumen, but also some of lesions were extraluminal, which stomach was most common site. stromal tumor account for a large proportion SMT. Due to deep lesion location gastric SMT, endoscopic dissection related techniques are difficult operate, while full-thickness resection (EFTR) has been widely used clinical practice because it is less invasive and can preserve physiological structure function stomach. However, complete...
Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of reproductive age cancer (EOC). Overall, 108 (≤ 40 years) diagnosed EOC who were treated at Peking Union Medical College Hospital between 1999 2013 included study. The Kaplan-Meier model Cox regression analyses used survival analysis. type fertility-sparing (FSS) (48.1%) radical (RS) (51.9%). After median follow-up 83 months,...
Abstract Background Despite rapid improvements in DNA methylation tools for cervical cancer screening, few robust, exploratory studies have been performed using the combination of two host genes, EPB41L3 and JAM3 , newly developed assays. Methods A review abnormal liquid-based cytology and/or high-risk human papillomavirus (hrHPV) data from outpatient clinics study center March 2018 to 2019 was performed. Eligible patients with definitive histological pathology results were included, their...
Intestinal stem cell (ISC) is a promising therapeutic target for inflammatory bowel disease. Cholesterol availability critical ISC stemness. Low plasma cholesterol typical feature of Crohn's disease (CD); however, its impact on mucosal healing remains unclear. Here, we identified an essential role sorting nexin 10 (SNX10) in maintaining the stemness ISCs. SNX10 expression intestinal tissues positively correlates with severity human CD and mouse colitis. Conditional knockout epithelial cells...
Owing to the rarity of sex cord tumor with annular tubules (SCTAT), it is difficult recognize SCTAT clinically and there no standard treatment. The aim our study was investigate treatment outcomes prognosis patients ovarian SCTAT.A cohort 13 diagnosed treated in Peking Union Medical College Hospital studied. Data on clinicopathological characteristics, treatment, were retrospectively reviewed analyzed.SCTAT accounted for 1.4% stromal tumors, an average onset age 22.6 years. All presented...
To assess the clinical outcomes and fertility of young women with stage I low-grade endometrial stromal sarcoma (ESS) treated fertility-sparing surgery.Seventeen patients ESS (stage IA, n = 6; IB, 11) were entered into this study. Adjuvant hormone therapy was administered to 15 (88.2%) patients. At a median follow-up 39 months (range, 4-106 months), 10 (58.8%) developed recurrence. All had IB disease; among them, first recurrence limited uterus observed in 6 17 alive disease-free at time...
Cronkhite-Canada syndrome (CCS) is a rare, nonhereditary disease characterized by diffuse gastrointestinal polyposis and ectodermal abnormalities. Although it has been proposed to be chronic inflammatory condition, direct evidence of its pathogenesis lacking. This study aims investigate the pathophysiology CCS analyzing transcriptomic changes in colonic microenvironment. Next-generation sequencing-based genome-wide transcriptional profiling was performed on hamartomatous polyps from four...
Objective: Little is known about the survival differences between uterine and extrauterine low-grade endometrial stromal sarcoma (LGESS). Survival outcomes, consisting of disease-free survivals overall survivals, were compared in these two entities. Methods: From February 2012 to June 2019, all primary LGESS cases with first recurrence study center reviewed. The clinicopathological characteristics outcomes patients for both recurrent diseases. Results: During period, 143 56 included followed...
Purpose To profile the characteristic and prognostic implications of venous thromboembolism (VTE) in Chinese ovarian clear cell carcinoma (CCC) patients. Methods We identified all cases between 2000 2012 by searching our institutional Ovarian CCC Database. A comprehensive review medical documentation was performed to collect relevant data. Kaplan-Meier models Cox regression were employed for survival analysis. Results Of 227 patients, 33 (14.5%) experienced VTE events. There no significant...
Ovarian clear cell carcinoma (CCC) is a distinct histologic subtype with relatively poor survival. No prognostic or predictive molecular marker currently available. Recent studies have shown that AT-rich interactive domain 1A (ARID1A) and phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) mutations are common genetic changes in ovarian CCC. Hepatocyte nuclear factor-1β (HNF-1β) expression has been proven to be highly sensitive specific for histology. However, the correlations...
Abstract Background Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease characterized by of histopathology existing in the lungs. Because its rarity, limited literature with single case or small number cases has been regarding to clinical course, pathology management PBML. Methods A retrospective study was performed all PBML diagnosed and managed at Peking Union Medical College Hospital (PUMCH) from 2001 2019. The characteristics, pathology, treatment outcomes each were...
Pulmonary benign metastasizing leiomyoma (PBML) is the most common extrauterine spread of uterine leiomyoma, and its biological behavior traditionally thought to be hormone dependent. Studies on older PBML patients have been previously reported, but limited literature has published regarding clinical features treatment in young women.A total 65 cases women aged 45 years younger were reviewed, including 56 selected from PubMed 9 our hospital. The characteristics management these analyzed.The...
Objective: Despite several nationwide cohort studies of germline BRCA1/2 mutations and small somatic in Chinese epithelial ovarian cancer (EOC) patients, little is known about the impact these findings on survival outcomes this population. In study 172 retrospectively recruited EOC their value for predicting were evaluated. Methods: Unselected patients who visited center from January 1, 2011, to 2015, asked provide peripheral blood samples if they pathologically confirmed have primary EOC....
The effectiveness of various strategies for the post-treatment monitoring cervical cancer is unclear. This pilot study was conducted to explore recurrence patterns in and diagnostic patients with uterine who were meticulously followed using a customized plan.The epidemiological clinical data recurrent treated from March 2012 April 2018 at tertiary teaching hospital retrospectively collected. methods their reliability compared across clinicopathological characteristics associated survival...
INTRODUCTION: The prognosis of Cronkhite–Canada syndrome (CCS) is considered poor. Despite the recent therapeutic improvements, survival outcomes and prognostic factors have been less studied. This study aimed to investigate long-term clinical endoscopic CCS. METHODS: Thirty-one patients diagnosed since 1999 followed up for over 6 months were included. Data regarding outcomes, symptoms, findings, treatment collected analyzed. R (version 3.6.1) was used perform analyses. RESULTS: median...
Objective: The identification of DNA polymerase epsilon (POLE) mutation subtypes in endometrial cancer is critical for molecular classification. the POLE gene could only be detected by sequencing until now. We propose to validate and develop feasibility using BaseScope, an situ hybridization (ISH) assay, detection mutations high-grade endometrioid carcinomas (EC). Methods: Among 51 paraffin-embedded samples EC, BaseScope-ISH assays were used detect RNA status gene, mainly focusing on two...
Background Fertility-sparing surgery (FSS) has been widely used for patients with early-stage mucinous ovarian carcinoma (MOC). However, there is limited evidence regarding the reproductive outcomes as well impact of growth pattern on oncological after FSS. This study aims to evaluate and stage I primary MOC Methods retrospective enrolled 159 women histologically confirmed unilateral treated at Peking Union Medical College Hospital between 1997 2019. Sixty-seven cases were pathologically...
In a previous training set with case-controlled design, cutoff values for host EPB41L3 and JAM3 gene methylation were obtained the detection of cervical intraepithelial neoplasia (CIN) 2 or more severe lesions (CIN2+). This validation trial was conducted to evaluate role DNA in screening CIN2+ by cytology among unselected participants.From June 1, 2019, September our study center, we collected liquid-based samples from swabs assays hrHPV testing eligible patients. The primary endpoint...