A5050026660- Gestational Trophoblastic Disease Studies
- Prenatal Screening and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Testicular diseases and treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Social Media and Politics
- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Marriage and Family Dynamics
- Teratomas and Epidermoid Cysts
- Endometriosis Research and Treatment
- Neonatal Health and Biochemistry
- Reproductive System and Pregnancy
- Cancer Genomics and Diagnostics
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Tuberous Sclerosis Complex Research
- Lung Cancer Diagnosis and Treatment
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Beijing Chao-Yang Hospital
2025
Capital Medical University
2025
Hubei University
2025
Shandong First Medical University
2024
Shandong Tumor Hospital
2024
National Clinical Research Center for Digestive Diseases
2022-2023
Obstetrics and Gynecology Hospital of Fudan University
2023
Weatherford College
2021
Aims The B7 family check‐point molecules are potential therapeutic targets in cancer immunotherapy. However, their expression status human gestational trophoblastic neoplasia (GTN) remains unknown. We investigated the profiles of proteins PD‐L1, PD‐L2, B7‐H3, B7‐H4, VISTA and B7‐H6 GTN clinical significance. Methods results identified 112 patients with GTN, including 68 choriocarcinoma, 33 placental‐site tumour (PSTT) 11 epithelioid (ETT). Immunohistochemical staining was performed on...
To explore the measures to improve follow-up rate of preterm infants after discharge, and evaluate effectiveness these using quality improvement methodology. The status discharged from March May 2017 was used as baseline before improvement, a specific goal for proposed. Pareto chart analyze causes failure, key driver diagram constructed based on links involved in improving rate. failure were analyzed determine intervention monitored weekly control until achieved. discharge 57.92% (117/202)...
Phototherapy is the standard treatment, but its efficacy can vary among neonates, prompting interest in genetic factors, particularly UGT1A1 gene variants. This study aims to evaluate clinical significance of variant influencing phototherapy response and long-term outcomes neonatal hyperbilirubinemia. retrospective included 104 neonates with hyperbilirubinemia, whom 63 carried normal gene, 41 had homozygous Gly71Arg variant. Genetic testing for locus been previously conducted as part their...
Objective: To investigate the clinicopathological features and prognostic characteristics of endometrial clear cell carcinoma (ECCC), evaluate 2023 Federation International Gynecology Obstetrics (FIGO) staging system on prognosis ECCC. Methods: The information patients with ECCC who underwent primary surgery in Peking Union Medical College Hospital from March 2012 to December was collected. early advanced stages were defined as Stage Ⅰ-Ⅱ Ⅲ-Ⅳ, respectively. Cox proportional hazard regression...
To observe the effect of electroacupuncture (EA) pretreatment "biaoben acupoint combination" on cardiomyocyte mitochondrial fission in rats with myocardial ischemia-reperfusion injury (MIRI) and explore its mechanism. Fifty male SD were randomly divided into a sham-operation group, model an EA + Compound C group pretreatment+ML385 10 each group. In pretreatment, was delivered at bilateral "Neiguan" (PC6), "Zusanli" (ST36) "Guanyuan" (CV4) for 20 min, continuous wave 2 Hz frequency, 1 mA...
The optimal treatment for patients with brain metastasis from gestational trophoblastic neoplasia (GTN) has not been established. This study aims to investigate the clinical characteristics and management of GTN in relation patients’ outcomes. We retrospectively investigated 109 treated at Peking Union Medical College Hospital January 1990 December 2013. Patients mainly received multiagent chemotherapy florouracil or floxuridine, dactinomycin, etoposide, vincristine (FAEV) combined...
Background: Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational neoplasias. We investigated clinical features, treatments, outcomes, and prognostic factors in patients with ETT, explored potential therapeutic targets. Methods: retrospectively analyzed survival, 21 ETT treated at our institution between January 2002 December 2017. Expression levels programmed cell death 1 (PD-1), PD-1 ligands (PD-L1and PD-L2), B7 family (B7-H3, B7-H4, V-domain Ig suppressor T activation...
Objective: To analyze the management and prognosis of primary choriocarcinoma (PCC) in male patients. Methods: The clinical records males with PCC who were treated at Peking Union Medical College Hospital between 1990 2012 analyzed retrospectively. literature regarding this condition was also reviewed. Results: median survival interval 13 patients 54 months (range, 6–115 months), 1- 3-year rates 53.8% 43.1%, respectively. All surgery; 12 combined chemotherapy. After including 100 cases found...
<h3>Introduction:</h3> The objective of the study was to investigate clinical characters, diagnosis, treatment, and prognosis nongestational ovarian choriocarcinoma. <h3>Methods:</h3> A retrospective analysis done on 21 patients with choriocarcinoma treated in Peking Union Medical College Hospital from January 1985 October 2008. All patients9 conditions were diagnosed by histopathologic examination; 3 them, diagnosis confirmed DNA polymorphism at 12 short tandem repeat loci....
Pathological examination combined with tumor markers has become a standard for the diagnosis of intracranial germ cell tumors (ICGCTs), but current concept 'secreting tumors' and three empirically highly specific diagnostic criteria (β-hCG ≥ 50 IU/L or αFP 10 ng/mL; β-hCG 100 > 25 ng/mL) are not based upon pathology CSF cytology. Further investigation is needed to re-evaluate their value.A multidisciplinary team was created. Valid β-hCG/αFP data were collected from cases ICGCTs confirmed by...
The objective of our study was to investigate the clinical characteristics and prognosis postterm choriocarcinoma patients at Peking Union Medical College Hospital within past 30 years. pertinent follow-up data 272 with diagnosed from December 1985 through 2014 in hospital were reviewed. two cohorts cut off 2006 compared using χ 2 tests. Risk factors estimated by multivariate Cox proportional regression analysis. most common initial symptom abnormal uterine bleeding. After individualized...
Abstract Background Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease characterized by of histopathology existing in the lungs. Because its rarity, limited literature with single case or small number cases has been regarding to clinical course, pathology management PBML. Methods A retrospective study was performed all PBML diagnosed and managed at Peking Union Medical College Hospital (PUMCH) from 2001 2019. The characteristics, pathology, treatment outcomes each were...
Abstract Objective We investigated the clinical characteristics, treatments, and survival of patients with gestational trophoblastic neoplasia (GTN) who experienced recurrence. Factors predictive recurrence were also investigated. Methods Patients GTN recurred after completing chemotherapy at Peking Union Medical College Hospital Trophoblastic Disease Center identified between January 2004 December 2017. Logistic regression analysis was used to identify factors Results A total 1827 achieved...
Treatment options for heavily pre-treated recurrent ovarian and endometrial cancer are limited. Lenvatinib plus anti-programmed cell death protein-1 (PD-1) combination therapy has been efficacious in advanced cancer, but at the recommended dose level, high-grade adverse events occur lead to drug discontinuation. This study evaluated feasibility of low-dose lenvatinib anti-PD-1 patients with cancer.
A retrospective analysis of 123 postpartum choriocarcinoma cases treated at the Peking Union Medical College Hospital between December 1985 and 2006 was performed. All patients with received chemotherapy, combined comprehensive therapy. The total number chemotherapy cycles 1041 (8.5 for every patient on average). complete remission (CR) achieved in 108 (87.8%), whereas five had partial ten died. Of 26 who became resistant to 5-fluorouracil 18 CR. four recurrence, three were divided into...
Endometrial carcinoma with a germ cell tumor component is rare event. Here we report uterine neoplasm unique combination of endometrioid adenocarcinoma and mixed malignant elements. A 28-year-old woman abnormal vaginal bleeding, an abdominal mass, elevated alfa-fetoprotein beta-human chorionic gonadotropin (β-hCG) levels had history biopsy omental mass chemotherapy in another hospital one month before her referral to our department. Histologic examination the removed from omentum revealed...