A5076649367- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Genetics and Neurodevelopmental Disorders
- Genetic Neurodegenerative Diseases
- Cytomegalovirus and herpesvirus research
- Cellular transport and secretion
- RNA regulation and disease
- Herpesvirus Infections and Treatments
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Infectious Encephalopathies and Encephalitis
- Polyomavirus and related diseases
- Prion Diseases and Protein Misfolding
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- Bacterial Infections and Vaccines
- Neuroscience and Neuropharmacology Research
- Glycogen Storage Diseases and Myoclonus
- CNS Lymphoma Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- interferon and immune responses
- Infectious Diseases and Tuberculosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Multiple Sclerosis Research Studies
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Chengdu University of Traditional Chinese Medicine
2024
Academy of Medical Sciences
2014-2021
Academia Sinica
2019-2021
China-Japan Friendship Hospital
2021
Chifeng University
2021
Yangzhou University
2021
Union Hospital
2019
National Natural Science Foundation of China
2016
<h3>Objective</h3> To describe the detailed clinical characteristics, immunotherapy, and long-term outcomes of patients with anti-NMDA receptor (NMDAR) encephalitis in China. <h3>Methods</h3> A single-center, prospective study. Patients who met diagnostic criteria were enrolled from 2011 to 2017 followed up. The features, treatment, collected prospectively. Factors affecting prognosis analyzed. <h3>Results</h3> study included 220 patients. most common presentations psychosis (82.7%) seizures...
Pseudorabies virus (PRV) has been thought to cause diseases only in animals. However, recent studies have shown that PRV can also illnesses humans.This was a case series study. The cases of five patients with clinical symptoms acute encephalitis, which were confirmed be caused by infections, reviewed.The all had jobs involving the handling pigs. They onset and rapid progression presentations, consistent central nervous system infections. Four them respiratory failure, required ventilator...
The application of metagenomic next-generation sequencing (mNGS) in the diagnosis tuberculous meningitis (TBM) remains poorly characterized. Here, we retrospectively analyzed data from patients with TBM who had taken both mNGS and conventional tests including culture Mycobacterium tuberculosis (MTB), polymerase chain reaction (PCR) acid-fast bacillus (AFB) stain, sensitivity specificity these methods were compared.We recruited admitted to hospital between December 2015 October 2018. first...
Background: The complications of coronavirus disease 2019 (COVID-19) involved multiple organs or systems, especially in critically ill patients. We aim to investigate the neurological patients with COVID-19. Methods: This retrospective single-center case series analyzed COVID-19 at intensive care unit Tongji Hospital, Wuhan, China from February 5 April 2, 2020. Demographic data, clinical and laboratory findings, comorbidities treatments were collected analyzed. Results: Among 86 confirmed...
BackgroundBrucellosis is the most common zoonotic infection in world. Brucellosis with nervous system involvement known as 'neurobrucellosis' (NB). The diagnosis of NB difficult because its clinical manifestations are non-specific and sensitivity routine culture tests low.MethodsNext-generation sequencing (NGS) cerebrospinal fluid (CSF) was used to detect pathogens patients clinically suspected central (CNS) infections at a tertiary referral center China between June 1, 2016 2017....
Some recent studies suggest that some imaging-negative temporal lobe epilepsy (TLE) had significant amygdala enlargement (AE). Contradictory data were also reported in previous regarding the association between AE and TLE. The present study was to investigate clinical characters of a group TLE with compare volume same patient before after antiepileptic drugs treatment by larger sample size.This recruited 33 mesial patients 35 healthy volunteers. history, seizure semiology,...
Autoimmune encephalitis associated with antibodies against γ-aminobutyric acid B receptor (GABA R) in patients limbic (LE) was first described 2010. We present a series of Han Chinese for further clinical refinement.Serum and cerebrospinal fluid (CSF) samples from referred to the program paraneoplastic syndrome Peking Union Medical College Hospital were tested indirect immunofluorescence. Clinical information anti-GABA R antibody positivity retrospectively reviewed, descriptive statistical...
Background and PurposezzEncephalitis caused by Listeria monocytogenes (L.monocytogenes) is rare but sometimes fatal.Early diagnosis difficult using routine cerebrospinal fluid (CSF) tests, while next-generation sequencing (NGS) increasingly being used for the detection characterization of pathogens.MethodszzThis study set up applied unbiased NGS to detect L. in CSF collected from three cases clinically suspected listeria meningoencephalitis.ResultszzThree patients with acute/subacute...
The aim of this study was to describe brain metabolic changing patterns demonstrated by serial FDG PET/CT scans and their relationship with the clinical course in patients anti-N-methyl-d-aspartate receptor encephalitis (ANMDARE).Eighteen PET 8 ANMDARE were reviewed. All 18 divided into 4 groups according studies timing different course: group A, acute subacute phase; B, early recovery C, D, relapsing phase. Antibody levels all these tested at same time. images each analyzed visually also...
Objective: To detect potential pathogens including pseudorabies virus in patients with encephalitis of unknown etiology China and describe novel encephalitic entities. Methods: Patients clinically suspected infectious were enrolled a multicenter study to identify the PUMCH Encephalitis Program.Next-generation sequencing(NGS) cerebrospinal fluid (CSF) was used from 2016 2017.The diagnosed as PRV studied this entity. Results: The four patients(3 male, 1 38-54 years old) had occupational...
Background: Neurocysticercosis (NCC) is the most common helminthic infection of central nervous system (CNS). The diagnosis NCC sometimes challenging due to its heterogenous clinical manifestations and variable sensitivity specificity neuroimaging serological tests. Methods: Next-generation sequencing (NGS) cerebrospinal fluid (CSF) was used detect pathogens in patients with clinically suspected CNS infections. A series diagnosed reviewed here. Results: Using NGS CSF, four were NCC. reads...
Background: In recent years, the phenomenon of coexisting systemic autoimmune diseases (ADs) in patients with encephalitis (AE) has been increasingly found, while its clinical significance remains unexplored. This study aimed to investigate types and potential associations comorbidities antibody-positive AE. Methods: A retrospective cohort AE was conducted from 2011 2018. The demographics, characteristics, follow-up data were reviewed. Results: We enrolled 517 patients, among whom 45...
To present 6 new cases with Homer-3 antibodies that expand their clinical spectra and to evaluate the effect of immunotherapy.Patients suspected autoimmune cerebellar disorder were tested for rare ataxia (ACA) (anti-Tr(DNER)/Zic4/ITPR1/Homer-3/NCDN/PKCγ/PCA-2/AP3B2/mGluR1/ATP1A3 antibodies) using both cell-based tissue-based assays. Patients positive serum or CSF results who diagnosed ACA registered followed up. This study reports analyzes antibodies.Of samples 750 patients tested,...