A5100394227- Neuroblastoma Research and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neurofibromatosis and Schwannoma Cases
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Amyotrophic Lateral Sclerosis Research
- Meningioma and schwannoma management
- Intracerebral and Subarachnoid Hemorrhage Research
- Multiple Sclerosis Research Studies
- Cardiac tumors and thrombi
- Peptidase Inhibition and Analysis
- Neurological diseases and metabolism
- Medical Imaging Techniques and Applications
- Balance, Gait, and Falls Prevention
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Sarcoma Diagnosis and Treatment
- Vestibular and auditory disorders
- Hereditary Neurological Disorders
- Glioma Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Adrenal and Paraganglionic Tumors
- Plant-based Medicinal Research
First People's Hospital of Chongqing
2025
Peking Union Medical College Hospital
2010-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
Fudan University
2013-2023
Zhongshan Hospital of Xiamen University
2023
Huashan Hospital
2013-2022
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2022
Soochow University
2022
UPMC Presbyterian
2021
Beijing Sport University
2021
Abstract Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are essential for neuronal survival but the developmental timing and mechanistic importance mitochondrial dysfunction in sporadic ALS (sALS) neurons not fully understood. We used human induced pluripotent stem cells generated a timeline differentiating sALS iPSCs to neural progenitors comparing parameters with familial (fALS) control at each stage. report...
Abstract A 7-year-old girl with known brain metastasis from neuroblastoma developed new onset of severe headache. MRI confirmed in the right frontal lobe without abnormalities. The patient was enrolled a clinical trial using 18 F-MFBG PET/CT to evaluate patients neuroblastoma. images abnormal activity lesion lobe. In addition, PET showed additional foci left cerebellopontine region. follow-up study acquired 4 months later revealed signals same
The aim of this study was to describe brain metabolic changing patterns demonstrated by serial FDG PET/CT scans and their relationship with the clinical course in patients anti-N-methyl-d-aspartate receptor encephalitis (ANMDARE).Eighteen PET 8 ANMDARE were reviewed. All 18 divided into 4 groups according studies timing different course: group A, acute subacute phase; B, early recovery C, D, relapsing phase. Antibody levels all these tested at same time. images each analyzed visually also...
Neurofibromatosis type I (NF1) is a genetic disorder caused by mutations in the NF1 tumor suppressor gene. Neurofibromin encoded and functions as negative regulator of Ras activity. patients develop renal artery stenosis arterial occlusions resulting cerebral visceral infarcts. Further, vascular neurofibromas where vessels are invested dense pericyte sheath. Although it well established that aberrations signaling lead to human malignancies, emerging data generated genetically engineered...
POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein elevation, and skin changes) syndrome is a rare paraneoplastic caused by an underlying plasma cell disorder. The patients usually present with multisystemic involvement. Thus, we performed study to investigate the role of (18)F-FDG PET/CT in characterizing syndrome.Ninety-one untreated proven or suspected were recruited undergo PET/CT. Features bone lesions, lymphadenopathy, hepatomegaly splenomegaly, marrow, serous cavity...
Recognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy. We aimed to identify factors that predicted among AQP4-ab-positive NMOSD, develop outcome prediction models, and validate them a multicenter validation cohort.Between January 2015 December 2020, 820 NMOSD were registered at Huashan Hospital. retrospectively reviewed their medical...
Genetic inactivation of tumor suppressor genes initiates human cancers. However, interaction accessory cells with the tumor-initiating cell within microenvironment is often required for progression. This paradigm relevant to understanding neurofibroma development in neurofibromatosis type I patients. Somatic Nf1 gene, which encodes neurofibromin, necessary but not sufficient initiate development. In contrast, neurofibromas occur high penetrance mice ablated Schwann context a heterozygous...
This study evaluated the efficacy of human mesenchymal stem cells (hMSCs) in treatment intracerebral hematoma (ICH) using a primate model and serial <sup>18</sup>F-FDG PET scans. <b>Methods:</b> Twenty-four <i>Macaca fascicularis</i> monkeys (male, 4.2 ± 0.2 kg) were enrolled. The ICH models established stereo-guided injection 1.5 mL autologous arterial blood between right cortex basal ganglia. One week (early group, <i>n</i> = 8) or 4 wk (late after an was established, (1–5) ×10<sup>6</sup>...
Parkinson's disease primarily results from progressive degeneration of dopaminergic neurons in the substantia nigra. Both neuronal toxicants and genetic factors are suggested to be involved pathogenesis. The mitochondrial toxicant 1-methyl-4-phenylpyridinium (MPP(+)) shows a highly selective toxicity neurons. Recent studies indicate that mutation vacuolar protein sorting 35 (vps35) gene segregates with some families, but how vps35 causes cell death is not known. Here, we report enhanced...
Our previous studies have demonstrated that activation of group I metabotropic glutamate receptors downregulated Kir channels in chronic ocular hypertension (COH) rats, thus contributing to Müller cell gliosis, characterized by upregulated expression glial fibrillary acidic protein (GFAP). In the present study, we explored possible signaling pathways linking channel inhibition and GFAP upregulation. normal retinas, intravitreal injection BaCl2 significantly increased cells, which was...
Background— Neurofibromatosis type 1 (NF1) is a genetic disorder resulting from mutations in the NF1 tumor suppressor gene. Neurofibromin, protein product of , functions as negative regulator Ras activity circulating hematopoietic and vascular wall cells, which are critical for maintaining vessel homeostasis. patients have evidence chronic inflammation development premature cardiovascular disease, including arterial aneurysms, may manifest sudden death. However, molecular pathogenesis...
To measure motor function improvements in patients with Parkinson's disease (PD) using Health Qigong exercises.Fifty-two PD (Hoehn and Yahr stages I to IV) were randomly divided into experimental control groups. Twenty-six the group intervened routine medicine fitness exercise. The other 26 as treated only regular medication. Twelve-week intervention had been conducted for study, participants completed scheduled exercises 4 times per week 60 minutes each time. Data which included one-legged...
Transcranial alternating current stimulation (tACS) offers another method of non-invasive brain in post-stroke rehabilitation. Because it is not known if tACS over bilateral mastoids (tACSbm) can promote the functional recovery subacute patients, we wish to learn effect tACSbm on improving neurological function and intracranial hemodynamics patients.Sixty patients (mean age: 65.4 ± 9.8 years), 15 60 days after onset, were randomly assigned receiving sessions usual rehabilitation program...
Foodborne botulism is a rare but life-threatening illness resulting from the action of potent toxin mainly produced by Clostridium botulinum. It grows in an oxygen-deficient environment and extremely viable meat soy products, making it one most virulent bacteria. How to track foodborne events quickly accurately has become key issue. Here, we investigated two that occurred Xinjiang 2019 based on whole-genome sequencing also successfully traced relationship between clinical food C. botulinum...
Recently, five novel single nucleotide polymorphisms (SNPs), rs10937625 in STK32B (serine/threonine kinase 32B), rs17590046 PPARGC1A (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), and rs12764057, rs10822974, rs7903491 CTNNA3 (catenin alpha 3), were found to be associated with increased risk of essential tremor (ET) a genome-wide association study (GWAS)in individuals Caucasian ancestry. Considering the overlap between ET Parkinson's disease (PD) pathological features...
Background: Diabetic retinopathy, a vascular complication of diabetes mellitus, is the leading cause visual impairment and blindness. circRNAs act as competing endogenous RNA, sponging target miRNA thus influencing mRNA expression in diseases. We investigated whether how circDNMT3B involved retinal dysfunction under diabetic conditions. Methods: qRT-PCR was performed to detect circDNMT3B, miR-20b-5p, BAMBI microvascular endothelial cells Western blot, Cell Counting Kit-8, Transwell, Matrigel...
AbstractContext: Heterotopic ossification is characterized by abnormal growth of bone in soft tissues. Neurogenic heterotopic also closely related to central nervous system injuries and has been reported respond radial extracorporeal shock wave therapy.Findings: In this case, a therapy (five times per week, lasted for almost one year) was applied patient with neurogenic on the left hip as result spinal cord injury. Throughout treatment session, lesion gradually diminished, associated...