A5101695851- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Microbial Inactivation Methods
- Microfluidic and Bio-sensing Technologies
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- RNA modifications and cancer
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Dental materials and restorations
- Magnetic and Electromagnetic Effects
- RNA Research and Splicing
- Transgenic Plants and Applications
- Tactile and Sensory Interactions
- Traditional Chinese Medicine Analysis
- Zebrafish Biomedical Research Applications
- Neonatal Health and Biochemistry
- Retinal Diseases and Treatments
- Pharmacological Effects of Natural Compounds
- Energy Harvesting in Wireless Networks
- Metabolism and Genetic Disorders
- Mycobacterium research and diagnosis
- Glaucoma and retinal disorders
- Ion channel regulation and function
Tianjin Medical University
2015-2022
Tianjin Medical University Cancer Institute and Hospital
2022
State Key Laboratory of Medical Neurobiology
2019-2021
Fudan University
2019-2021
Nantong Maternity and Child Health Hospital
2021
Nantong University
2021
Zhongshan Hospital
2019
The Ohio State University
2009-2014
Beijing Hospital
2011
Chinese Academy of Sciences
2007
Graziano, Michael S. A., Xin Tian Hu, and Charles G. Gross. Visuospatial properties of ventral premotor cortex. J. Neurophysiol. 77: 2268–2292, 1997. In macaque cortex, we recorded the activity neurons that responded to both visual tactile stimuli. For these bimodal cells, receptive field extended from into adjacent space. Their fields were organized topographically, with arms represented medially, face in middle, inside mouth laterally. many neurons, responses directionally selective,...
Diabetic retinopathy, a vascular complication of diabetes mellitus, is the leading cause visual impairment and blindness. circRNAs act as competing endogenous RNA, sponging target miRNA thus influencing mRNA expression in diseases. We investigated whether how circDNMT3B involved retinal dysfunction under diabetic conditions.qRT-PCR was performed to detect circDNMT3B, miR-20b-5p, BAMBI microvascular endothelial cells conditions. Western blot, Cell Counting Kit-8, Transwell, Matrigel tube...
Glaucoma, the leading cause of irreversible blindness, is a retinal neurodegenerative disease, which results from progressive apoptotic death ganglion cells (RGCs). Although mechanisms underlying RGC apoptosis in glaucoma are extremely complicated, an abnormal cross-talk between glial and RGCs generally thought to be involved. However, how interaction Müller microglia, two types cells, contributes injury largely unknown.A mouse chronic ocular hypertension (COH) experimental model was...
The purpose of this study was to compare the shaping ability ProTaper Universal (PTU; Dentsply Maillefer, Ballaigues, Switzerland), WaveOne (WO; Maillefer) and Next (PTN; in simulated L-shaped S-shaped root canals respectively.30 30 resin blocks were employed randomly divided into 3 groups (n = 10), respectively. prepared a tip size 25 using PTU, WO or PTN: PTU F2 (taper 0.08 over first mm from apical tip), Primary PTN X2 0.06 tip). Photos taken pre- postinstrumentation. 2 layers...
Electroporation is one of the most popular nonviral gene transfer methods for embryonic stem cell transfection. Bulk electroporation techniques, however, require a high electrical field and provide nonuniform distribution among randomly distributed cells, leading to limited transfection efficiency viability, especially low number cells. We present here membrane sandwich system using well-defined micronozzle array. This device capable transfecting hundred millions cells with good performance....
Electropermeabilization or electroporation is the electrical disruption of a cell's membrane to introduce drugs, DNA/RNA, proteins, other therapies into cell. Despite four decades study, fundamental science process remains poorly understood and controversial. We measured minimum applied electric field required for permeabilization suspended spherical cells as function cell radius three lines. Key this work our use optical tweezers precisely position individual enable well-defined, repeatable...
Abstract Background Emerging transcriptome-wide high-throughput screenings reveal the landscape and functions of RNAs, such as circular RNAs (circRNAs), in human cancer. In addition, post-transcriptional RNA internal modifications, especially N 6 -methyladenosine (m A), greatly enrich variety metabolism. However, m A modification on circRNAs has yet to be addressed. Results Here, we report an epitranscriptome-wide mapping A-modified A-circRNA) oral squamous cell carcinoma (OSCC). Utilizing...
Recently, circular RNAs (circRNAs) have become an intense focus of research and large numbers circRNAs been identified, awaiting functional elucidation. Thus, the present study aims to examine regulation its molecular mechanism in lung cancer growth. Here, we show that RNA circ_0000677 was overexpressed correlated with poor prognosis non-small cell (NSCLC) patients. Functionally, knockdown markedly inhibited proliferation NSCLC cells by observing immunofluorescence staining Ki67, clone...
Background: Cancer metastasis-related chemoresistance and tumour progression are the leading causes of death among CRC patients. Therefore, it is urgent to identify reliable novel biomarkers for predicting metastasis CRC. Methods: The gene expression corresponding clinical data patients were downloaded from Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Univariate multivariate analyses performed prognostic lncRNAs. Nomograms constructed, predictive accuracy nomogram model was...
Background: Diabetic retinopathy, a vascular complication of diabetes mellitus, is the leading cause visual impairment and blindness. circRNAs act as competing endogenous RNA, sponging target miRNA thus influencing mRNA expression in diseases. We investigated whether how circDNMT3B involved retinal dysfunction under diabetic conditions. Methods: qRT-PCR was performed to detect circDNMT3B, miR-20b-5p, BAMBI microvascular endothelial cells Western blot, Cell Counting Kit-8, Transwell, Matrigel...
We report a fundamental study of how the electropermeabilization cell is affected by nearby cells. Previous researchers studying electroporation dense suspensions cells have observed, both theoretically and experimentally, that such samples cannot be treated simply as collections independent However, complexity those systems makes quantitative modeling difficult. studied change in minimum applied electric field, threshold required to affect due presence second cell. Experimentally, we used...
Abstract Monkeys have strong abilities to remember the visual properties of potential food sources for survival in nature. The present study demonstrated first observations rhesus monkeys learning solve complex spatial mazes which routes were guided by cues. Three trained a maze (6 m × 6 m) included four different mazes. We recorded cue and cup errors, latencies, pathway each trial. data showed that learned target place after three days spent shorter time following was an efficient method...
Abstract Emerging transcriptome high throughput screenings reveal the landscape and functions of RNAs, such as circular RNAs (circRNAs), in human cancer. In addition, post-transcriptional internal modifications, especially N 6 -methyladenosine (m A), greatly enrich variety metabolism. However, m A modification on circRNAs has yet to be addressed. Here, we report an epitranscriptome-wide mapping A-modified A-circRNA) oral squamous cell carcinoma (OSCC). Utilizing data MeRIP-seq A-circRNAs...