A5089662379- Neurofibromatosis and Schwannoma Cases
- DNA Repair Mechanisms
- Peptidase Inhibition and Analysis
- Fungal and yeast genetics research
- Connective tissue disorders research
- Aortic aneurysm repair treatments
- Genomics and Chromatin Dynamics
- Cardiac tumors and thrombi
- CRISPR and Genetic Engineering
- Neuropeptides and Animal Physiology
- Neuroblastoma Research and Treatments
- Signaling Pathways in Disease
- Carcinogens and Genotoxicity Assessment
- Plant Genetic and Mutation Studies
- Phagocytosis and Immune Regulation
- Aortic Disease and Treatment Approaches
- Macrophage Migration Inhibitory Factor
- Chromosomal and Genetic Variations
- Cardiovascular Issues in Pregnancy
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
Washington University in St. Louis
2018-2020
Indiana University – Purdue University Indianapolis
2008-2018
University of Indianapolis
2018
Indiana University School of Medicine
2013-2016
Indiana University
2013
Duke University
2007
Inverted DNA repeats are known to cause genomic instabilities.Here we demonstrate that double-strand breaks (DSBs) introduced a large distance from inverted in the yeast (Saccharomyces cerevisiae) chromosome lead burst of instability.Inverted located as far 21 kb each other caused rearrangements response single DSB.We DSB initiates pairing interaction between repeats, resulting formation dicentric dimers.Furthermore, observed propagation cells containing dimers led gross chromosomal...
Abstract Break-induced replication (BIR) is an important process of DNA metabolism that has been implicated in the restart collapsed forks, as well various chromosomal instabilities, including loss heterozygosity, translocations, and alternative telomere lengthening. Therefore, knowledge how BIR carried out regulated for better understanding maintenance genomic stability eukaryotes. Here we present a new yeast experimental system enables genetic control to be investigated. Analysis mutations...
Background— Neurofibromatosis type 1 (NF1) is a genetic disorder resulting from mutations in the NF1 tumor suppressor gene. Neurofibromin, protein product of , functions as negative regulator Ras activity circulating hematopoietic and vascular wall cells, which are critical for maintaining vessel homeostasis. patients have evidence chronic inflammation development premature cardiovascular disease, including arterial aneurysms, may manifest sudden death. However, molecular pathogenesis...
Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor-suppressor gene, which encodes neurofibromin, a negative regulator of diverse Ras signaling cascades. Arterial stenosis is nonneoplastic manifestation that predisposes some patients to debilitating morbidity and sudden death. Recent murine studies demonstrate Nf1 heterozygosity (Nf1(+/-)) monocytes/macrophages significantly enhances intimal proliferation after arterial injury. However, downstream effector pathway...
Double strand DNA breaks (DSBs) are dangerous events that can result from various causes including environmental assaults or the collapse of replication. While efficient and precise repair DSBs is essential for cell survival, faulty lead to genetic instability, making choice DSB an important step. Here we report inverted repeats (IRs) placed near a channel its accurate pathway leads gene conversion instead break-induced replication (BIR) instabilities. The effect IRs explained by their...
Objectives Marfan syndrome and Ehlers-Danlos represent two connective tissue vascular diseases requiring unique consideration in their surgical care. A comprehensive national review encompassing all hospitalizations for the Syndrome patient population is lacking. Methods The National (Nationwide) Inpatient Sample from 2010 to 2014 was reviewed inpatient surgery procedures including those with a diagnosis of syndrome. estimates rates were generated provided weights. Patient demographics,...