A5083690679- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Neurogenesis and neuroplasticity mechanisms
- Cellular Mechanics and Interactions
- Ocular Diseases and Behçet’s Syndrome
- CNS Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Lymphoblastic Leukemia research
- Reproductive System and Pregnancy
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Autoimmune Neurological Disorders and Treatments
- Spinal Cord Injury Research
- Cell Image Analysis Techniques
- Bacterial Infections and Vaccines
- Pregnancy-related medical research
- Parkinson's Disease Mechanisms and Treatments
- Coronary Artery Anomalies
- T-cell and B-cell Immunology
- Retinal and Optic Conditions
- Psoriasis: Treatment and Pathogenesis
- Polyomavirus and related diseases
- Cardiac tumors and thrombi
Fudan University
2015-2024
Huashan Hospital
2015-2024
Shanghai Medical College of Fudan University
2014
Background and purpose Besides a distinct spectrum of demyelinating syndromes, encephalitis was observed in patients with myelin oligodendrocyte glycoprotein antibodies ( MOG ‐abs). Methods The clinical records 690 idiopathic diseases the central nervous system seen our center from June 2015 to December 2017 were retrospectively reviewed. All underwent serum aquaporin 4 antibody AQP 4‐ab) ‐ab detection by cell‐based assays as routine diagnostic approach. Patients MOG‐abs or AQP4‐abs who had...
Current understanding of the alterations in retinal vascular network neuromyelitis optica spectrum disorders (NMOSDs) is limited. We aim to assess peripapillary and parafoveal vessel density aquaporin-4 antibody-positive NMOSD patients by optical coherence tomography (OCT) angiography.A total 55 with or without a history optic neuritis (ON) 33 healthy controls underwent spectral domain OCT angiography. Clinical histories, Expanded Disability Status Scale score, visual functional system score...
Objective: To evaluate the potential of serum neurofilament light (sNfL) and glial fibrillary acidic protein (sGFAP) as disease biomarkers in neuromyelitis optica spectrum disorder (NMOSD) with aquaporin-4 antibody (AQP4-ab) or myelin oligodendrocyte glycoprotein-antibody-associated (MOGAD). Methods: Patients AQP4-ab-positive NMOSD ( n = 51), MOGAD 42), relapsing-remitting multiple sclerosis (RRMS) 31 for sNfL 22 sGFAP testing), well healthy controls (HCs) 28), were enrolled prospectively....
To identify factors associated with relapse risk and disability in myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD).Between 2016 2021, 186 patients MOGAD were included the study. Factors a relapsing course, annualised rate (ARR), recurrent relapses under different maintenance treatments unfavourable outcome analysed.MOGAD affects women (53.8%) slightly more often than men. After median disease duration of 51.0 months, 60.2% (112/186) relapsed, an overall ARR 0.5. The...
Recognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy. We aimed to identify factors that predicted among AQP4-ab-positive NMOSD, develop outcome prediction models, and validate them a multicenter validation cohort.Between January 2015 December 2020, 820 NMOSD were registered at Huashan Hospital. retrospectively reviewed their medical...
Prodromal infections are associated with neuromyelitis optica spectrum disorder (NMOSD), but it remains unclear which type of infection has a causal association NMOSD. We aimed to explore the associations between four herpesvirus (chickenpox, cold sores, mononucleosis and shingles) NMOSD, as well other types NMOSD.For data on infections, we used genome-wide study (GWAS) summary statistics from 23andMe cohort. For outcomes, GWAS participants European ancestry, including 215 NMOSD patients...
Abstract Background and purpose Data regarding the efficacy safety of currently widely available preventive therapies in neuromyelitis optica spectrum disorder (NMOSD) are needed. We compared azathioprine (AZA), mycophenolate mofetil (MMF), reduced dose rituximab (RTX) NMOSD based on a large multicenter retrospective cohort. Methods Patients with aquaporin 4 (AQP4) antibody‐positive AZA ( n = 167), MMF 131), or RTX 55) as initial treatment were included. The main outcome was occurrence...
Neuromyelitis optica spectrum disorder (NMOSD) is a severe neurological inflammatory disease mainly caused by pathogenic aquaporin-4 antibodies (AQP4-IgG). The safety and efficacy of the neonatal Fc receptor antagonist batoclimab addition to conventional intravenous methylprednisolone pulse (IVMP) therapy in patients with NMOSD acute attacks was assessed.In an open-label, dose-escalation phase 1b study, myelitis and/or optic neuritis received four doses weekly subcutaneous injections either...
Abstract Background and purpose Myelitis is an important clinical component of myelin oligodendrocyte glycoprotein antibody (MOG‐ab)‐associated disease (MOGAD) aquaporin‐4 (AQP4‐ab)‐positive neuromyelitis optica spectrum disorder (NMOSD). The aim this work was to evaluate the differentiating features myelitis between two diseases. Methods Myelitis‐related radiologic data from 130 patients with MOGAD 125 AQP4‐ab–positive NMOSD were retrospectively reviewed compared. A scoring model...
The aims of this study were to report the effectiveness and safety teriflunomide in Chinese patients with relapsing-remitting multiple sclerosis (RRMS) explore association paramagnetic rim lesion (PRL) burden patient outcome context treatment impact on PRL burden. This is a prospective observational study. A total 100 RRMS treated ≥3 months included analyzing drug persistence safety. Among them, 96 ≥6 assessing aspects no evidence disease activity (NEDA) 3. number volume calculated 76...
Objectives To investigate the influence of pregnancy on patients with neuromyelitis optica spectrum disorder (NMOSD) and to identify risk factors that predict pregnancy-related attack. Methods From January 2015 April 2019, 418 female NMOSD were registered at Huashan Hospital. We retrospectively reviewed their medical records identified 110 136 informative pregnancies, whom 83 aquaporin-4 antibody (AQP4-ab)-positive 21 myelin oligodendrocyte glycoprotein-antibody-positive. Pregnancy-related...
To determine retinal vessel density in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).Twenty-five MOGAD and 20 healthy participants were enrolled. Patients divided into antibody (MOG-Ab)-positive eyes a history of optic neuritis (ON; MOG-Ab-ON+ group) or without ON (MOG-Ab-ON- group). Visual function, densities, thickness measured.The nerve fiber layer, parafoveal ganglion cell inner plexiform layers, densities the peripapillary areas significantly...
Both myelin oligodendrocyte glycoprotein-IgG associated disorders (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD) are demyelinating diseases of the central nervous system. They present similar clinical manifestations such as neuritis, myelitis area postrema syndrome (APS). The distinctions neuritis (ON) between them have been elaborated to great length while their differences in APS remain be elucidated. We aim report frequency patients with MOGAD well NNOSD patients, compare...
This study aimed to evaluate the clinical characteristics and prognosis of late onset (≥50 years) neuromyelitis optica spectrum disorder (LO-NMOSD), compare them with those early (<50 NMOSD (EO-NMOSD) various antibody serostatuses.From January 2015 December 2020, 360 anti-aquaporin 4 (AQP4-ab)-positive 130 anti-myelin oligodendrocyte glycoprotein (MOG-ab)-positive patients presented Huashan Hospital, China. We retrospectively reviewed their medical records, including Expanded Disability...