A5101830817- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Genetic Mapping and Diversity in Plants and Animals
- Rice Cultivation and Yield Improvement
- GABA and Rice Research
- Genetics and Plant Breeding
- Autoimmune and Inflammatory Disorders Research
- Plant Disease Resistance and Genetics
- Potato Plant Research
- Plant Pathogens and Resistance
- Genetic and phenotypic traits in livestock
- Acute Lymphoblastic Leukemia research
- Neuroinflammation and Neurodegeneration Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Animal testing and alternatives
- Medicinal Plant Pharmacodynamics Research
- Neurological Disorders and Treatments
- 14-3-3 protein interactions
- RNA regulation and disease
- Cytomegalovirus and herpesvirus research
- Cell Image Analysis Techniques
- Inflammasome and immune disorders
First Affiliated Hospital of Wenzhou Medical University
2009-2024
Wenzhou Medical University
2009-2024
Huazhong Agricultural University
2018
Nanjing Institute of Vegetable Science
2018
Ministry of Education of the People's Republic of China
2018
China National Rice Research Institute
2009-2017
Chinese Academy of Agricultural Sciences
2015-2017
Dali University
2010
Abstract Exploitation of heterosis is one the most important applications genetics in agriculture. However, genetic mechanisms are only partly understood, and a global view from representative number hybrid combinations lacking. Here we develop an integrated genomic approach to construct genome map for 1,495 elite rice varieties their inbred parental lines. We investigate 38 agronomic traits identify 130 associated loci. In-depth analyses effects heterozygous genotypes reveal that there few...
Recognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy. We aimed to identify factors that predicted among AQP4-ab-positive NMOSD, develop outcome prediction models, and validate them a multicenter validation cohort.Between January 2015 December 2020, 820 NMOSD were registered at Huashan Hospital. retrospectively reviewed their medical...
Recombinant adeno-associated viruses (AAVs) have been widely used for gene delivery and therapy. However, certain AAV serotypes exhibited distinct transduction patterns among different mouse strains or between mice non-human primates (NHPs). These variations prompted us to investigate the tropism of 21 capsid variants using barcoded libraries tissues in C57BL/6 BALB/c mice, as well crab-eating macaques. Our study unveiled that tropisms varied significantly species, particularly such AAV4,...
Abstract Background and purpose Data regarding the efficacy safety of currently widely available preventive therapies in neuromyelitis optica spectrum disorder (NMOSD) are needed. We compared azathioprine (AZA), mycophenolate mofetil (MMF), reduced dose rituximab (RTX) NMOSD based on a large multicenter retrospective cohort. Methods Patients with aquaporin 4 (AQP4) antibody‐positive AZA ( n = 167), MMF 131), or RTX 55) as initial treatment were included. The main outcome was occurrence...
There have been reports of neuromyelitis optica spectrum disorder (NMOSD) coexisting with connective tissue disorders. The objective this study was to describe the characteristics NMOSD autoimmune diseases (AID).
Objectives To investigate the influence of pregnancy on patients with neuromyelitis optica spectrum disorder (NMOSD) and to identify risk factors that predict pregnancy-related attack. Methods From January 2015 April 2019, 418 female NMOSD were registered at Huashan Hospital. We retrospectively reviewed their medical records identified 110 136 informative pregnancies, whom 83 aquaporin-4 antibody (AQP4-ab)-positive 21 myelin oligodendrocyte glycoprotein-antibody-positive. Pregnancy-related...
Purpose: To investigate the clinical character, diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy accompanying myasthenia gravis so as to improve understanding such diseases.Materials methods: A case combined with were analyzed retrospectively review literature.Results: This man was presented progressive sensory symptoms, flaccid tetraparesis, areflexia protein-cell dissociation cerebrospinal fluid. Nerve conduction study indicative neuropathy. He suspected treated...
Objective We previously identified the independent predictors of recurrent relapse in neuromyelitis optica spectrum disorder (NMOSD) with anti-aquaporin-4 antibody (AQP4-ab) and designed a nomogram to estimate 1- 2-year relapse-free probability, using Cox proportional hazard (Cox-PH) model, assuming that risk had linear correlation clinical variables. However, whether assumption fits real disease tragedy is unknown. aimed employ deep learning machine develop novel prediction model patients...
The impact of early intervention with immunosuppressive treatment (IST) in anti-Aquaporin4-antibody (AQP4-ab) seropositive neuromyelitis optica spectrum disorder (NMOSD) has not been thoroughly evaluated.
Azathioprine is widely used for neuromyelitis optica spectrum disorder (NMOSD) patients, while a consensus of timing to receive azathioprine has not been proposed.The objective this paper was evaluate the efficacy early access in NMOSD patients.We conducted retrospective review patients based on medical records. Included were divided into three groups: group IVMT + AZA, AZA after and IVMT. Time next relapse adopted as endpoint.Patients from had longer duration remission compared with ( p =...
Background Several studies have reported the efficacy and safety of rituximab (RTX) mycophenolate mofetil (MMF) in neuromyelitis optica spectrum disorder (NMOSD). This study aimed to evaluate long-term use low-dose RTX MMF Chinese patients with NMOSD. Methods We retrospectively reviewed data from NMOSD our hospital. The enrolled were administrated different immunosuppressive agents. accessed annual relapse rate (ARR), neurological disability (Expanded Disability Status Scale, EDSS), time...