A5072870107- Acute Ischemic Stroke Management
- Peripheral Neuropathies and Disorders
- Venous Thromboembolism Diagnosis and Management
- Multiple Sclerosis Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Myasthenia Gravis and Thymoma
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- Adipokines, Inflammation, and Metabolic Diseases
- Adenosine and Purinergic Signaling
- Liver Disease Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Autoimmune Neurological Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Parkinson's Disease and Spinal Disorders
- Macrophage Migration Inhibitory Factor
- Endoplasmic Reticulum Stress and Disease
- RNA regulation and disease
- Diabetic Foot Ulcer Assessment and Management
- Antifungal resistance and susceptibility
- Muscle and Compartmental Disorders
- Hemodynamic Monitoring and Therapy
- Advanced MRI Techniques and Applications
- Medicinal Plant Pharmacodynamics Research
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
Zhejiang Chinese Medical University
2022
Zhejiang Hospital
2022
Zhejiang Taizhou Hospital
2022
Shandong Provincial QianFoShan Hospital
2022
Shandong University
2022
Wenzhou City People's Hospital
2022
University of Arizona
2022
Systemic immune-inflammation index (SII), a novel inflammation derived from counts of circulating platelets, neutrophils and lymphocytes, has been studied in developing incident cancer. However, the clinical value SII acute ischemic stroke (AIS) patients had not further investigated. Therefore, we aimed to explore association between severity as well 3-month outcome AIS patients.A total 216 receiving intravenous thrombolysis (IVT) 875 healthy controls (HCs) were retrospectively recruited....
Stress hyperglycemia ratio (SHR), calculated as glucose/glycated hemoglobin, has recently been developed for assessing stress and could provide prognostic information various diseases. However, calculating SHR using random blood glucose (RBG) drawn on admission or fasting (FBG) lead to different results. This study intends evaluate the association between functional outcomes in patients with acute ischemic stroke (AIS) recombinant tissue plasminogen activator (r-tPA) intravenous...
Purpose/Aim of the study: Guillain Barré syndrome (GBS) is a severe peripheral nervous disease that leads to muscle weakness and areflexia. We now commonly accept synthesis inflammation immunity play key role in GBS pathogenesis. Many studies pointed out neutrophil-to-lymphocyte ratio (NLR) monocyte-to-lymphocyte (MLR) are novel promising markers or immunity. Our study aimed evaluate whether NLR MLR were associated not.Materials Methods: measured blood cell count 334 individuals including...
Abstract The dysfunction of stress granules (SGs) plays a crucial role in the pathogenesis various neurological disorders, with T cell intracellular antigen 1 (TIA1) being key component SGs. However, and mechanism TIA1‐mediated SGs experimental autoimmune encephalomyelitis (EAE) remain unclear. In this study, upregulation TIA1, its translocation from nucleus to cytoplasm, co‐localization G3BP1 (a marker SGs) are observed spinal cord neurons EAE mice. Deletion TIA1 CNS alleviates...
As a central hub for metabolism, the liver exhibits strong adaptability to maintain homeostasis in response food fluctuations throughout evolution. However, mechanisms governing this resilience remain incompletely understood. In study, we identified Receptor interacting protein kinase 1 (RIPK1) hepatocytes as critical regulator preserving hepatic during metabolic challenges, such short-term fasting or high-fat dieting. Our results demonstrated that hepatocyte-specific deficiency of RIPK1...
Background: Hepatic fibrosis, a chronic pathological condition, is associated with adverse outcomes in stroke patients. Cardioembolism (CE) common etiology of stroke, yet the association between hepatic fibrosis and CE remains understudied. Aim: This study aims to investigate CE-induced as well its impact on patient prognosis. Methods: retrospective included 344 acute ischemic (AIS) patients who underwent thrombolytic therapy. was assessed using Fibrosis-4 (FIB-4) index Aspartate...
ABSTRACT Discrepancies in serum electrolyte levels have been observed between stroke patients and healthy individuals. Previous studies indicated an association electrolytes all‐cause mortality as well cardiovascular events patients. However, there still lacks comprehensive analysis on the connection negative outcomes hypertensive individuals with early neurological deterioration (END). Totally 1341 treated thrombolysis for acute ischemic at First Affiliated Hospital of Wenzhou Medical...
Abstract Background Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by infiltration immune cells into brain and demyelination. The unwanted immunosuppressive side effect therapeutically successful natalizumab led us to focus on choroid plexus (CP), a key site for first wave cell in experimental encephalomyelitis (EAE), control trafficking. Adenosine A 2A receptor (A R) emerging as potential pharmacological target EAE pathogenesis. However, cellular basis...
Abstract This study is to investigate the therapeutic effects of human adipose tissue-derived stem cell (hADSC) transplantation on experimental autoimmune encephalomyelitis (EAE) in mice. EAE mouse model was established by MOG35-55 immunization. Body weight and neurological function were assessed. H&E LFB staining performed evaluate histopathological changes. Flow cytometry used detect Th17 Treg cells. ELISA real-time PCR determine transcription factor pro-inflammatory cytokine levels....
Free radical toxicity due to poorly maintained cellular redox levels is crucial events that have been associated with the pathogenesis of Guillain–Barre syndrome (GBS) patients. Uric acid (UA) and albumin correlate oxidative stress in some degree. We aimed evaluate relationship between GBS serum UA present study. The were determined 203 individuals including 88 patients 153 healthy controls (HC). found significantly lower than those HC group. Besides, similar phenomenon was observed when...
Objective: We aimed to investigate whether platelet volume indices (PVIs) were associated with an unfavorable clinical outcome in acute ischemic stroke (AIS) patients undergoing intravenous thrombolysis (IVT).Methods: defined a modified Rankin Scale (mRS) score of 3–6 at 90 days as outcome. Logistic regression analysis was performed find out mean (MPV), distribution width (PDW), MPV/platelet count (PC) ratio and PDW/PC poor prognosis. A Spearman correlation test carried assess the...
Red blood cell (RBC) distribution width (RDW) is known to reflect the heterogeneity of RBC volume, which may be associated with cardiovascular events or mortality after myocardial infarction. However, association between RDW and stroke, especially regarding endpoints such as death, remains ambiguous. This study aimed explore prognostic value its effect on among patients acute ischemic stroke (AIS) undergoing intravenous thrombolysis (IVT) one year.We retrospectively reviewed AIS treated IVT...
The relationship between peripheral inflammatory markers, their dynamic changes, and the disease severity of myasthenia gravis (MG) is still not fully understood. Besides, possibility using it to predict short-term poor outcome MG patients have been demonstrated. This study aims investigate markers changes with Myasthenia Gravis Foundation America (MGFA) classification (primary outcome) (secondary in patients. retrospectively enrolled 154 from June 2016 December 2021. logistic regression was...
There have been reports of neuromyelitis optica spectrum disorder (NMOSD) coexisting with connective tissue disorders. The objective this study was to describe the characteristics NMOSD autoimmune diseases (AID).
Objective: Previous studies reported a lower platelet count (PC) level and higher mean volume (MPV) in severe ischemic stroke. We define MPV/PC as the ratio (PR). This study investigates relationship between PR 90-day outcome of large artery atherosclerosis (LAA) stroke.Materials Methods: A retrospective analysis was conducted on 338 LAA patients two hospitals by looking up electronic medical record (EMR). The functional divided into good poor according to modified Rankin Scale (mRS)...
Oxidative stress and variations in antioxidant status are implicated the pathogenesis of inflammatory autoimmune diseases. Polymyositis dermatomyositis (PM/DM) diseases with cells infiltrating into skeletal muscles, is still controversial. The aim our study was to investigate correlation between PM/DM serum bilirubin (Tbil, Dbil Ibil) uric acid (UA).We measured concentrations 384 individuals, including 110 patients 274 healthy controls.We found that had significantly lower (Tbil than...
Serum albumin (S-Alb) is a widely used biomarker of nutritional status and disease severity in patients with autoimmune diseases. We investigated the correlation between S-Alb myasthenia gravis (MG). A total number 166 subjects were recruited study. Subjects divided into 3 groups (T1 to T3) by levels: T1: 21.1 38.4 g/L, T2: 38.5 41.5 T3: 41.6 48.9 g/L. Regression analysis was performed determine initial concentrations MG. Lower levels observed increased than those slight severity, meanwhile,...
Albumin to globulin ratio (A/G) has been established as a representative biomarker for assessing inflammation and nutritional status. However, the prognostic value of A/G rarely reported in acute ischemic stroke (AIS) patients with intravenous thrombolysis (IVT).A total 311 AIS who had undergone IVT completed 3-month follow-up were retrospectively recruited this study. (Alb), (Glb) on admission, within 24 hours after day 7 recorded. Poor outcome was defined death or major disability...
White blood cell count to mean platelet volume ratio (WMR) is increasingly recognized as a promising biomarker. However, its predictive capability for acute ischemic stroke (AIS) patients relatively less researched. The primary aim of this study explore prognostic value in AIS after reperfusion regarding 3-month poor functional outcome.A total 549 who had undergone vascular procedure with complete follow-up were retrospectively recruited study. count, at 24 h admission recorded. Stroke...
Myasthenia gravis (MG) is a chronic autoimmune disease caused by neuromuscular junction (NMJ) dysfunction. Our current understanding of MG's inflammatory component remains poor. The systemic response index (SIRI) presents promising yet unexplored biomarker for assessing MG severity. This study aimed to investigate the potential relationship between SIRI and
As a central hub for metabolism, the liver exhibits strong adaptability to maintain homeostasis in response food fluctuations throughout evolution. However, mechanisms governing this resilience remain incompletely understood. In study, we identified Receptor interacting protein kinase 1 (RIPK1) hepatocytes as critical regulator preserving hepatic during metabolic challenges, such short-term fasting or high-fat dieting. Our results demonstrated that hepatocyte-specific deficiency of RIPK1...
It is well known that dendritic cells play a key role in producing antigen-specific responses. Inversely, tolerogenic (TolDCs), specialized subset, induce immune tolerance and negatively regulate autoimmune Statins, the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase mevalonate pathway for cholesterol biosynthesis, might be promising inductive agent inducing TolDCs. This study aimed to investigate effectiveness TolDCs induced by atorvastatin pulsed with myelin oligodendrocyte...