A5100703558- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Kruppel-like factors research
- Myasthenia Gravis and Thymoma
- Traumatic Brain Injury and Neurovascular Disturbances
- Autophagy in Disease and Therapy
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Immune cells in cancer
- S100 Proteins and Annexins
- Extracellular vesicles in disease
- Peripheral Neuropathies and Disorders
- Plant-derived Lignans Synthesis and Bioactivity
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Spinal Cord Injury Research
- Biochemical effects in animals
- Polyomavirus and related diseases
- Enzyme-mediated dye degradation
- Calpain Protease Function and Regulation
- Salivary Gland Disorders and Functions
- Fungal Biology and Applications
- Axon Guidance and Neuronal Signaling
- Medical and Biological Ozone Research
- Clusterin in disease pathology
Shenzhen Institutes of Advanced Technology
2025
Shenzhen University
2025
Soochow University
2017-2024
First Affiliated Hospital of Soochow University
2017-2024
Chengdu University
2020
Ministry of Agriculture and Rural Affairs
2020
National Natural Science Foundation of China
2017
Wenzhou Medical University
2015-2017
First Affiliated Hospital of Wenzhou Medical University
2015-2017
Air Force Medical University
2017
Dysregulation of microRNAs (miRNAs) has been found in injured spinal cords after cord injury (SCI). Previous studies have shown that miR-133b plays an important role the differentiation neurons and outgrowth neurites. Recently, exosomes used as novel biological vehicles to transfer miRNAs locally or systemically, but little is known about effect delivery exosome-mediated on treatment SCI. In present study, we observed mesenchymal stem cells, most common cell types produce exosomes, could...
Mechanical stress has detrimental effects on cartilaginous endplate chondrocytes due to apoptosis in vivo and vitro. In this study, we investigated the possible signaling pathways induced by mechanical cultured rat cervical chondrocytes. Static load significantly reduced cell viability a time- load-dependent manner, as demonstrated Cell Counting Kit-8 (CCK-8) assay. Chondrocyte was confirmed annexin V/propidium iodide (PI) staining terminal deoxynucleotidyl transferase dUTP nick-end labeling...
Abstract Background Microglial activation-mediated neuroinflammation is a major contributor to early brain injury (EBI) after subarachnoid hemorrhage (SAH). MicroRNA-124 (miR-124) the most abundant miRNAs in central nervous system (CNS) and plays vital role microglial activation by targeting protein CCAAT-enhancer-binding α (C/EBPα). It has been reported that CX3CL1/CX3CR1 axis involved delivery of miR-124 from neurons microglia. Methods An experimental rat SAH model was established...
In infants, high fever is associated with robust microglial morphological changes, including process retraction and soma enlargement, which contribute to fever-induced seizures. The molecular mechanisms underlying dynamic during hyperthermia remain poorly understood. Using a hyperthermia-induced activation model in postnatal day 8 mice, we identified the CX3CL1-CX3CR1 interaction as key regulator of retraction. CX3CL1 mainly cleaved by metalloproteases ADAM10 under stimulation....
Objective: Oxidative stress and low antioxidant status play a major role in the pathogenesis of inflammatory autoimmune diseases. Myasthenia gravis (MG) is an condition targeting neuromuscular junction, its still controversial. Our study aimed to investigate correlation between clinical characteristics MG serum bilirubin (Tbil, Dbil Ibil), uric acid, albumin creatinine. Materials methods: We measured molecule levels creatinine 380 individuals, including 166 214 healthy controls. Results:...
Free radical toxicity due to poorly maintained cellular redox levels is crucial events that have been associated with the pathogenesis of Guillain–Barre syndrome (GBS) patients. Uric acid (UA) and albumin correlate oxidative stress in some degree. We aimed evaluate relationship between GBS serum UA present study. The were determined 203 individuals including 88 patients 153 healthy controls (HC). found significantly lower than those HC group. Besides, similar phenomenon was observed when...
Background and Purpose- RACK1 (receptor for activated protein kinase C 1) is an integral component of ribosomes with neuroprotective functions. The goal this study was to determine the role in cerebral ischemia-reperfusion (I/R) injury underlying mechanisms. Methods- A middle artery occlusion/reperfusion model adult male Sprague Dawley rats (250-280 g) established, cultured neurons were exposed oxygen-glucose deprivation/reoxygenation mimic I/R vitro. Expression vectors encoding wild-type...
Though the pathogenesis of myasthenia gravis (MG) is not fully understood, role inflammation has been well appreciated in development MG. We aimed to investigate neutrophil-to-lymphocyte ratio (NLR) MG patients and relationship between NLR activity disease. A total number 172 207 healthy controls (HC) were enrolled this study. The divided into tertiles according (low < 1.58, n = 57; intermediate 1.58-2.33, 57 high > 2.33, 58). disease assessment was performed standard criteria established by...
Abstract Sleep disorder is becoming a widespread problem in current society, and associated with impaired cognition emotional disorders. Progranulin (PGRN), also known as granulin epithelin precursor, promotes neurite outgrowth cell survival, encoded by the GRN gene. It tumor necrosis factor α receptor (TNFR) ligand which implicated many central nervous system diseases. However, role PGRN sleep remains unclear. In present study, we found that deprivation (S-DEP) memory produced...
Serum albumin (S-Alb) is a widely used biomarker of nutritional status and disease severity in patients with autoimmune diseases. We investigated the correlation between S-Alb myasthenia gravis (MG). A total number 166 subjects were recruited study. Subjects divided into 3 groups (T1 to T3) by levels: T1: 21.1 38.4 g/L, T2: 38.5 41.5 T3: 41.6 48.9 g/L. Regression analysis was performed determine initial concentrations MG. Lower levels observed increased than those slight severity, meanwhile,...
This study aimed to estimate the role of phosphatidylethanolamine binding protein 1 (PEBP1) in cerebral ischemia-reperfusion (I/R) injury and underlying mechanisms. Middle artery occlusion/ reperfusion (MCAO/R) model adult male Sprague Dawley rats (250-280 g) were established cultured neurons exposed oxygen-glucose deprivation/reoxygenation (OGD/R) mimic I/R vitro. Expression vectors encoding wild-type PEBP1 with Ser153Ala mutation (S153A), specific siRNAs, human recombinant (rhPEBP1)...
Introduction Neuroinflammation serves as a critical local defense mechanism against secondary brain injury following intracerebral hemorrhage (ICH), and astrocytes play prominent role in this process. In study, we investigated astrocytic changes during the inflammatory state after ICH to identify new targets for improving response. Methods We stimulated mouse with lipopolysaccharide (LPS) vitro analyzed their transcriptomes via ribonucleic acid sequencing. created an model living organisms...
Uric acid (UA), the final product of purine metabolism, has been reported to be reduced in patients with various neurological disorders and is considered a possible indicator for monitoring disability progression multiple sclerosis. However, it remains unclear whether there close relationship between UA myasthenia gravis (MG), or primarily deficient secondarily because its peroxynitrite scavenging activity. We investigated correlation serum levels clinical characteristics MG. assessed 338...