New measurements of the chromatic difference focus human eye were obtained with a two-color, vernier-alignment technique. The results used to redefine variation refractive index reduced over visible spectrum. was further modified by changing refracting surface an aspherical shape reduce amount spherical aberration. resulting chromatic-eye model provides improved account both longitudinal and transverse forms ocular

We aimed to study the outcomes of mitral valve (MV) reoperations in children with congenital MV diseases and summarize our treatment experience. In this single-center retrospective study, we enrolled 24 patients aged < 18 years who underwent reoperation from among 265 repair between January 2013 July 2023. were based on types disease. Cox regressions used analyze risk factors for death second reoperation. A total 5 reoperations. 3 experienced early death, 1 late death. The 3- 5-year survival...

To explore effects of repetitive transcranial magnetic stimulation (rTMS) combined with direct current (tDCS) on motor function and cortex excitability in subacute stroke patients.Randomized controlled trial.Inpatient hospitals.Sixty-five participants were randomly assigned to four groups: sham, 1Hz rTMS, cathodic tDCS rTMS (tDCS-/rTMS-) anodic (tDCS+/rTMS-).Four interventions used, including cathodal or anodal tDCS, followed by over contralesional cortex, which continued for weeks.Outcome...

Previous optical modeling of the human eye with large pupils has predicted a larger impact defocus on contrast sensitivity function and modulation transfer than is observed experimentally. Theory predicts that aberrations Stiles–Crawford effect (SCE) should both lead to increased depth focus, resulting in higher sensitivities veridical (not phase-reversed) perception over range spatial frequencies defocused retinal images. Using wave optics model, we examine these predictions quantitatively...

Objectives To evaluate the impact of oseltamivir prophylaxis in management and control influenza outbreaks long-term care facilities Alberta, Canada. Setting participants Long-term where 127 were reported to public health authorities Canada, during two seasons from 2013 2015. Design outcome measures Using routinely collected surveillance administrative data, we examined association between decision-making time for recommendation as strategy (explanatory variable) duration an outbreak,...

Congenital heart disease (CHD) is a leading cause of birth defect-related mortality. However, more recent CHD mortality data for China are lacking. Additionally, limited studies have evaluated sex, rural-urban, and region-specific disparities in China.

ABSTRACT Varicella-zoster virus (VZV) glycoprotein gI is a type 1 transmembrane which one component of the heterodimeric gE:gI Fc receptor complex. Like VZV gE, was phosphorylated in both VZV-infected cells and gI-transfected cells. Preliminary studies demonstrated that serine 343-proline 344 sequence located within cytoplasmic tail most likely phosphorylation site. To determine protein kinase catalyzed event, we constructed fusion protein, consisting glutathione- S -transferase (GST) tail,...

ABSTRACT We previously showed that intradermal immunization with plasmids expressing the murine cytomegalovirus (MCMV) protein IE1-pp89 or M84 protects against viral challenge and coimmunization has a synergistic protective effect (C. S. Morello, L. D. Cranmer, H. Spector, J. Virol. 74:3696-3708, 2000). Using an intracellular gamma interferon cytokine staining assay, we have now characterized CD8 + T-cell response after DNA pp89, M84, pp89 plus M84. The pp89- M84-specific responses peaked...

BACKGROUND: Few studies have investigated the factors associated with asthma in young Aboriginal children. OBJECTIVE: To characterize association of demographic, environmental and early life children Canada. METHODS: The 2006 Children’s Survey was conducted among off-reserve zero to six years age obtain information on children’s development well-being. prevalence obtained from parental report as diagnosed by a health care professional. RESULTS: reported (n=14,170) 9.4%. Asthma both...

Abstract Aim Limited data have been available regarding critical congenital heart disease ( CHD ) screening in neonatal intensive care unit NICU s). This study evaluated the feasibility of for by adding pulse oximetry POX to clinical evaluation a Shanghai, China. Methods We screened 4128 eligible consecutive admissions using plus evaluation. Infants with positive results were then echocardiography. Those negative put under observation, and they also underwent echocardiography if their oxygen...

We previously demonstrated that vaccination of BALB/c mice with a pool 13 plasmid DNAs (pDNAs) expressing murine cytomegalovirus (MCMV) genes followed by formalin-inactivated MCMV (FI-MCMV) resulted in complete protection against viral replication the spleen and salivary glands following sublethal intraperitoneal (i.p.) challenge. Here, we found intranasal (i.n.) challenge, titers virus lungs immunized were reduced approximately 1,000-fold relative to those for mock-immunized controls. next...

The study demonstrated that overexpressed CK1α positively regulated autophagy activity through the HIF-1α pathway to promote progression. Thus, might be a potential treatment target for glioblastoma.

Human cytomegalovirus (CMV) establishes a lifelong persistent infection characterized by periods of latency and sporadic viral replication is major infectious cause birth defects following congenital infection. Currently, no licensed vaccine available that would prevent CMV In an effort to develop prophylactic vaccine, the effects different formulations, immunization routes delivery devices on immunogenicity plasmid DNA (pDNA)-based vaccines were evaluated in rabbits mice. Compared with PBS-...

The aberrant constitutive activation of nuclear factor-κB (NF-κB) has been observed in glioblastomas, while NF-κB inhibitor alpha (NFKBIA) inhibits the signaling pathway under several physiological processes. However, contribution NFKBIA to glioblastomas is poorly understood. In present study, using gene sequencing, we identified rs1957106 as a novel single nucleotide polymorphism (SNP) glioblastoma and found that it was more frequently patients. addition, examined association between...

Mutations in PINK1 gene have been considered the second most common cause of Autosomal Recessive Parkinsonism (ARP). So far, different homozygous mutations identified ARP patients. Abnormal hyperphosphorylation tau leads to loss its biological activity. Multiple lines evidence demonstrated that hyperphosphorylated is associated with Alzheimer's disease and Parkinson's (PD). However, effects PD phosphorylation are unknown. In this study, we investigated effect G309D mutation phosphorylation....

An obstacle in influenza therapeutics development is the lack of clinical endpoints, especially hospitalized patients. A single time-point binary outcome measure limited by patients' diverse trajectories and low event rates.A 6-point ordinal scale with ascending status severity (scoring: discharged; subacute care; acute care without/with respiratory failure; intensive unit [ICU]; death) was proposed to study outcomes adults influenza. Individual patient data from 2 active surveillance...

We previously demonstrated that after vaccination of BALB/c mice with DNA encoding murine cytomegalovirus (MCMV) IE1 or M84, a similar level protection against MCMV infection was achieved. However, the percentage antigen-specific CD8(+) T cells elicited by higher than M84 as measured intracellular cytokine staining when splenocytes were stimulated an epitope peptide (M. Ye at al., J. Virol. 76:2100-2112, 2002). show here M84-specific detected J774 expressing full-length M84. When defined...