A5080288502- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Congenital Heart Disease Studies
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Endometrial and Cervical Cancer Treatments
- Drug Transport and Resistance Mechanisms
- Mechanical Circulatory Support Devices
- Chronic Lymphocytic Leukemia Research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Cardiac and Coronary Surgery Techniques
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Anesthesia and Neurotoxicity Research
- Coronary Artery Anomalies
- Lipid metabolism and disorders
- Congenital heart defects research
- Cervical Cancer and HPV Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Reproductive tract infections research
- Synthesis and biological activity
- Liver Diseases and Immunity
Children's Hospital of Fudan University
2002-2025
Chinese PLA General Hospital
2006-2024
Southern Medical University
2022-2024
Fujian Medical University
2019-2024
Fuzhou Maternity and Child Health Care Hospital
2024
Nanfang Hospital
2022
Deyang Stomatological Hospital
2022
Shanghai Institute of Hematology
2020
National Synchrotron Radiation Laboratory
2017
University of Science and Technology of China
2017
We aimed to study the outcomes of mitral valve (MV) reoperations in children with congenital MV diseases and summarize our treatment experience. In this single-center retrospective study, we enrolled 24 patients aged < 18 years who underwent reoperation from among 265 repair between January 2013 July 2023. were based on types disease. Cox regressions used analyze risk factors for death second reoperation. A total 5 reoperations. 3 experienced early death, 1 late death. The 3- 5-year survival...
Non-typhoidal salmonella (NTS) infection is a leading cause of acute gastroenteritis in children. Recently, NTS infections have increased, especially those associated with Salmonella Typhimurium, which has become global problem because its high level drug resistance. Diseases caused by serotypes vary considerably. We summarised among children Fuzhou, Fujian, China, from 2012 to 2021, and synthesised studies indicating the clinical symptoms, laboratory test results, resistance S. Typhimurium...
Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause injury, especially at high doses. Here, we investigated the role of FXR in high-dose OCA-induced hepatoxicity condition NAFLD mouse model. Methods: Wild-type (WT) mice and FXR-/- were administered with over-dose OCA (0.40%) (0.16%), high-fat diet. RNA-seq on samples fed was performed to dig out prominent biological events...
To investigate the role of triple combination serum heparin-binding protein (HBP), procalcitonin (PCT), and C-reactive (CRP) in children with acute bacterial upper respiratory tract infection (ABURTI). A total 130 admitted to Department Pediatrics Fujian Maternity Child Health Hospital from September 2019 January 2021 were selected as research group. According results pathogenic analysis, further subdivided into a group (n = 67) viral 63). Additionally, 65 who underwent physical examinations...
Obeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, is believed to alleviate nonalcoholic fatty liver disease (NAFLD) by decreasing hepatic lipogenesis in an FXR-dependent manner. Here, we revealed novel mechanism which OCA improves NAFLD affecting long-chain acids (LCFAs) uptake.Stably transfected HEK-293 cells expressing transport protein 5 (FATP5) were established examine uptake; FXR-/-, human (h) FATP5, and FXR-/-/hFATP5 mouse models incorporated explore the effects of on FATP5...
Ebola virus (EBOV) is highly lethal due to virally encoded immune antagonists, and the combination of EBOV VP24 with karyopherin alpha (KPNA) will trigger anti-interferon (IFN) signaling. The crystal structure VP24-KPNA5 has been proposed in recent studies, but precise binding mechanisms are still unclear. In order explore protein micro-mechanisms, Molecular Dynamic (MD) simulations Mechanics Generalized Born Surface Area (MM-GB/SA) energy calculation performed. obtained results show that...
Background Endometrial carcinoma (EC) and serous ovarian (OvCa) are both among the common cancer types in women. EC can be divided into two subtypes, endometroid serous-like EC, with distinct histological characterizations molecular phenotypes. There is an increasing awareness that resembles OvCa genetic landscape, but a clear relationship between them still lacking. Methods Here, we took advantage of large-scale profiling The Cancer Genome Atlas(TCGA) to compare subtypes OvCa. We used...
Multifunctional viral protein (VP35) encoded by the highly pathogenic Ebola viruses (EBOVs) can antagonize host double-stranded RNA (dsRNA) sensors and immune response because of simultaneous recognition dsRNA backbone blunt ends. Mutation select hydrophobic conserved basic residues within VP35 inhibitory domain (IID) abrogates its dsRNA-binding activity, impairs VP35-mediated interferon (IFN) antagonism. Herein detailed binding mechanism between WT, single mutant, double mutant were...
Hyperlipidemia is characterized by elevated levels of blood lipids. The clinical manifestations are mainly atherosclerosis caused the deposition lipids in vascular endothelium. link between abnormal lipid metabolism and sudden hearing loss remains unclear. This article presents a case study accompanied familial hyperlipidemia. Pure tone audiometry indicated intermediate frequency one ear. Laboratory tests showed metabolism, genetic examination identified heterozygous mutation
Background: Children are at increased risk for respiratory tract infections (RTIs) due to their developing pulmonary functions and immune systems, highlighting the necessity of accurate rapid pathogen diagnostic methods. While targeted next-generation sequencing (tNGS) has shown higher sensitivity compared conventional microbiological tests (CMTs), studies focused on pediatric RTIs limited. Methods: In this study, 940 patients with were included who hospitalized Qingdao Huangdao District...
Background: This study intended to investigate the correlation between insulin resistance (IR) and coagulation parameters in women with polycystic ovary syndrome (PCOS) their effects on infertility. Methods: We retrospectively included 380 PCOS patients 143 healthy controls January 2018 2021. Clinical data, including age; body mass index; white blood cell (WBC), neutrophil (NE), lymphocyte (Lym), platelet (PLT) counts; D-dimer, plasma sex hormone, fasting sugar, levels, were collected. The...
Fat mass and obesity-associated protein (FTO) was the earliest discovered m6A RNA demethylase. Previous studies have indicated that modifications significantly influence development, progression, prognosis of various cancers. This study aimed to explore role FTO overexpression in colorectal cancer as well its biological functions. Expression levels mRNA adjacent non-cancerous tissues were assessed using RT-PCR immunohistochemistry. achieved by transiently transfecting an plasmid into HCT15...
Cyclosporine A and sirolimus are immunosuppressants that widely used in many organ transplantation procedures. They exhibit some complementary mechanisms of action interact synergistically when together. However， they critical-dose drugs have a narrow therapeutic index. provide the desired effect with acceptable tolerability only within specific range blood concentrations. Therefore， rapid simultaneous detection concentrations cyclosporine whole could valuable information on planning...
After primary mitral valve (MV) repair, residual regurgitation (MR) and recurred stenosis (MS) are the principal occurrences. This study's purpose is to identify risk factors of MV dysfunction, reoperation death following repair diseases.We retrospectively reviewed 98 patients (47 males 51 females) with diseases between January 2013 December 2021. The median age was 34 months [interquartile range (IQR), 11.4-59] for male 24 (IQR, 7.35-72) female. left ventricular ejection fraction (LVEF),...
Objective: To validate the prognostic value of NCCN-International Prognostic Index (NCCN-IPI) for patients with peripheral T-cell lymphoma (PTCL) treated CHOP-based chemotherapy. Methods: A retrospective analysis in 162 PTCL who were initially diagnosed and Rui Jin Hospital from January 2003 to May 2013 was conducted. Baseline characteristics collected, survival performed according IPI NCCN-IPI model. Results: The estimated 5-year overall (OS) rate progression free (PFS) 33% 20%, median OS...
This study investigated the infection status and relationship between other common lower genital tract infectious pathogens high-risk human papillomavirus (HR-HPV) in high-grade cervical lesions.Overall, 882 patients were enrolled this retrospective study, of which 339 (≥HSIL group) confirmed with squamous intraepithelial lesions (HSIL) or cell carcinoma (SCC), while 543 (≤LSIL diagnosed low-grade (LSIL) normal pathology diagnosis. Cervical swab specimens tested for HPV, pathogenic bacteria...
The phenomenon of the soil arch effect anti-slide pile be discussed.Anti-slide resistance and soil-pile interaction being analyzed by three-dimensional numerical software FLAC3D With engineering examples as background to establish model, considering contact surface element properties.Demonstrates reliability model compared displacement sliding zone area monitoring scene field observation data analysis slide effect.After construction, shear stress nephogram mutagenesis oblique type "L" shape...